The application belongs to the technical field of hydrogel microneedles, and relates to a hydrogel microneedle and a preparation method thereof, and the preparation method comprises the following steps: placing a methacrylated
chitosan solution in a centrifugal tube, adding a
photoinitiator, vortexing and ultrasonicating until the
photoinitiator is completely dissolved to obtain a hydrogel microneedle filling solution; and taking the hydrogel microneedle filling solution and injecting the hydrogel microneedle filling solution into a PDMS microneedle mold, centrifuging, irradiating with an
ultraviolet lamp and
drying.The hydrogel microneedle prepared from methacrylated
chitosan has superior performance in
wound closure, re-epithelialization and
hair follicle formation, and the hydrogel microneedle is combined with a rhodioside
drug depot to construct a transdermal
drug delivery system, the
drug delivery system has high drug loading and no
polymer deposition, can efficiently transdermally deliver rhodioside, promotes
wound closure and
tissue remodeling, and provides a potential strategy for
wound treatment.