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Intelligent nano-medicament delivery system and preparation method and application thereof

A nano-drug and delivery system technology, applied in biomedical materials and nano-fields, can solve problems such as the inability to prepare pH-responsive smart nano-drug carriers, and achieve the effects of improving the ability to induce differentiation, increase cell intake, and increase toxicity

Inactive Publication Date: 2013-03-20
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the problem that the pH-responsive intelligent nano-drug carrier cannot be prepared from low-generation dendrimers, and to provide a preparation method and application of an intelligent nano-drug delivery system

Method used

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  • Intelligent nano-medicament delivery system and preparation method and application thereof
  • Intelligent nano-medicament delivery system and preparation method and application thereof
  • Intelligent nano-medicament delivery system and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Embodiment 1. Preparation of intelligent nano drug carrier

[0034] 0.045 mmol of 1-generation cholic acid-modified polyamide-amine dendrimers and 0.045 mmol of citraconic anhydride were dissolved in sodium carbonate buffer solution, and reacted at room temperature for 4 hours. Dialysis removes impurities. Freeze-dry to obtain citraconic acid cholic acid-modified polyamidoamine dendrimers.

Embodiment 2

[0035] Embodiment 2. Preparation of intelligent nano drug carrier

[0036] 0.045 mmol of 1-generation cholic acid-modified polyamide-amine dendrimers and 0.180 mmol of citraconic anhydride were dissolved in sodium carbonate buffer solution, and reacted at room temperature for 4 hours. Dialysis removes impurities. Freeze-dry to obtain citraconic acid cholic acid-modified polyamidoamine dendrimers.

Embodiment 3

[0037] Embodiment 3. Preparation of intelligent nano drug carrier

[0038] 0.045 mmol of 1-generation cholic acid-modified polyamidoamine dendrimers and 0.180 mmol of 3,4,5,6-tetrahydrophthalic anhydride were dissolved in sodium carbonate buffer solution, and reacted at room temperature for 4 hours. Dialysis removes impurities. The cholic acid 3,4,5,6-tetrahydrobenzene modified polyamidoamine dendrimer is obtained by freeze-drying.

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Abstract

The invention relates to an intelligent nano-medicament delivery system with pH responsiveness and a preparation method and application thereof. The delivery system comprises a nano-medicament carrier and a medicament encapsulated in the carrier, wherein the carrier is formed by a dendritic polymer and a molecular ligand connected to the carrier; the dendritic polymer is a polyamide-imide dendritic polymer or a polyamide-imide dendritic polymer containing cholate acid terminal group; and the molecular ligand is citraconic acid or 3, 4, 5, 6-tetrahydro benzoic acid. The medicament is an anti-tumor medicament or an induced differentiation medicament. The medicament delivery system is prepared by modifying a lower-generation polyamide-imide dendritic polymer, and the preparation process is simple. An experiment proves that the system plays a good cell delivery role on the anti-tumor medicament or a tumor differentiation medicament. The effect of the anti-tumor medicament can be effectively improved, the induced differentiation capability of an anti-differentiation medicament on cancer cells is improved, the toxic and side effect in an organism is small and the system can be used for treating cancers.

Description

technical field [0001] The invention belongs to the field of biomedical materials and nanotechnology, and in particular relates to a preparation method of an intelligent nano drug delivery system. Background technique [0002] Tumor is one of the main diseases that seriously endanger human health. Chemotherapy is the most important treatment method besides surgical therapy. At present, most of the drug molecules widely used clinically will be distributed in various organs in the body after entering the body, and there is little specific distribution to the lesion site. For these anticancer drugs with strong pharmacological effects, their cytotoxicity is very high. While effectively killing tumor cells, they will also destroy normal tissue cells, so they will also cause great toxicity to normal tissues or organs during treatment. , serious toxic and side effects occur, and the treatment dose brings great pain to the patient. In order to improve the specific effect of drugs...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/34A61K31/519A61K31/4745A61K31/704A61K31/203A61P35/00
Inventor 于奡王永健张堃王大伟齐林双
Owner NANKAI UNIV
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