Prasugrel hydrobromide polymorph and preparation method thereof
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- 江苏万全特创医药生物技术有限公司
- Publication Date
- 2010-12-01
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention belongs to the field of medicine and chemical industry, and in particular relates to a preparation method for synthesizing antithrombotic drug prasugrel (prasugrel) hydrobromide and polymorphs thereof. Background technique
[0002] The chemical name of prasugrel is 2-acetoxy-5-(a-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c ] pyridine, the structural formula is as shown in formula I. As a new generation of potent thienopyridine antiplatelet drugs, jointly developed by Sankyo Co., Ltd. and Eli Lilly and Company, it is used for the treatment of thrombosis.
[0003] Prasugrel is currently marketed in the form of hydrochloride, which is a prodrug that forms an active molecule after metabolism in the body, and binds to platelet P2Y receptors to exert anti-platelet aggregation activity. Clinical studies have proved that prasugrel has a better anticoagulant effect than the current mainstream drug clopidogrel. Compared wit...