260results about How to "High suppression efficiency" patented technology

The invention relates to the technical field of molecular biology and biological medicines, and particularly relates to application of gRNA sequences and combination thereof based on a CRISPR system in treatment on hepatitis B virus. According to the method disclosed by the invention, eight types of guidance RNAs (gRNA) are designed according to design rules of CRISPR gRNA and a conservative region of different genotypes of HBV sequences, and the eight types of guidance RNAs are structured on a PX330 expression vector. By utilizing the eight gRNAs in a cell model, a mouse model and a CRISPR/Cas9 system guided by combination of the cell model and the mouse model, the expression and replication of the hepatitis B virus can be effectively inhibited. By united application of a plurality of gRNAs, a better effect can be achieved, and different genotypes of HBV replication can be better inhibited. The system has the characteristics of being easy to operate, high in inhibition efficiency on HBV replication and applicable to various genotypes. Therefore, the gRNA and the combination thereof related to the invention are expected to be applied in preparation of a novel drug for treating the hepatitis B virus.

A multi-ply, expanded content wrap label includes a base ply and an upper ply thereon with adhesive applied to the underside of a trailing end of the base ply to form a splice between the base ply and the upper side of the upper ply when the label is applied to a container.

The invention discloses a platen machine which comprises a gantry frame and a compacting mould. The compacting mould is composed of multiply heating platens (2a), and an elastic connecting element (2b) is arranged between two adjacent heating platens. Each heating platen (2a) is hollow inside. A heat-exchanger tube (2a1) is arranged inside the platen machine, and the heat-exchanger tube (2a1) is connected with a heat transfer oil circulating system. Guide pillars (1a1, 1ab) used for guiding the multiply heating platens (2a) are arranged on the gantry frame. The platen machine also comprises a buffer device (3) which is fixedly connected on the bottom portion of the beam (1c) of the gantry frame, and is connected with the top layer heating platen of the multiply heating platens of the mould. The compacting mould is driven by a hydraulic cylinder (6) on the bottom portion of the compacting mould. A piston rod (6a) of the hydraulic cylinder is connected with the bottom layer heating platen. The platen machine can be used for compacting multiply wood plates each time, and compacting efficiency is high. Due to the fact heat transfer oil is adopted to transfer heat to the wood plates, the wood plates are heated up quickly, heat is distributed evenly, glue cement among the wood plates is enabled to solidify rapidly, compacting quality is high, and compacting speed is fast.

The invention discloses a full-automatic hydraulic press. An automatic charging part (A), a pressing and shaping part (C) and an intelligent robot material-distribution and built-in manipulator brick-clamping part (B) are respectively provided with a sensor; the sensors send collected signals to a control part; the central processing unit of the control part processes a fed signal to judge and send an order to each terminal; after the automatic charging part finishes charging, the intelligent robot distributes the material; an elastic mode of double surface adding and pressurization is adopted for pressing and shaping; the automatic charging part carries out next charging circulation while pressing and shaping; after the product is shaped, the product is pushed out by a product die retracting device; and the intelligent robot material-distribution and built-in manipulator brick-clamping part carries out next material distribution circulation while the product is clamped to a transportation part by the built-in manipulator, thereby realizing automatic production for the whole process. The full-automatic hydraulic press can effectively improve production efficiency and product quality, lowers production cost, is safe, environmentally-friendly and efficient and saves energy.

The invention relates to a pressing device, in particular to an efficient mosaic tile pressing device. The technical problem is solved by providing the efficient mosaic tile pressing device with high pressing efficiency. In order to solve the technical problem, the invention provides the efficient mosaic tile pressing device. The efficient mosaic tile pressing device comprises a bottom plate, a pressing box, a supporting plate, a first cylinder, a placing platform, a supporting rod, a rack, a gear, a lifting rod, a guide sleeve, a pushing block, a first motor, an elliptical cam, a small belt pulley, a first rotating shaft, a second motor, a big belt pulley, a flat belt and the like; the supporting rod, the pressing box and a right support are sequentially arranged at the top of the bottom plate from the left side to the right side; the placing platform is arranged at the top end of the supporting rod. The high-efficiency mosaic tile pressing device achieves the effect of high pressing efficiency; due to arrangement of the second motor and the first motor, the second motor and the first motor drive a first pressing block and a placing plate to press powder at the same time.

The invention relates to a method for inhibiting generation of grease in an MTO alkali wash system, and mainly solves the problem about much grease in the prior art. According to the adopted method for inhibiting generation of grease in the MTO alkali wash system, a grease inhibitor is added into an MTO alkali wash tower, and the inhibitor comprises 5-15 percent of an antioxidant, 10-20 percent of a polymerization inhibitor, 5-15 percent of a dispersing agent and 50-80 percent of a solvent in mass fraction; the antioxidant is 2,5-di-tert-butylhydroquinone diphosphonate, the polymerization inhibitor is triacetonamine, and the dispersing agent is sodium thiosulfate. Due to adoption of the technical scheme, the problem can be better solved, and the method can be used for inhibition of generation of the grease in the MTO alkali wash system.

The invention discloses a toggle lever metal extruder, which comprises a framework-type rack and is creatively characterized in that a workbench is arranged at the lower part of the rack, a sliding block is arranged above the workbench and can reciprocate on the rack along a vertical direction, and two sides of the work bench are provided with lateral pressing cylinders; a toggle lever mechanism is arranged on the upper part of the rack and mainly comprises an upper support, an upper toggle lever, a lower toggle lever and a lower support; and a driving mechanism is arranged outside the togglelever mechanism and comprises a hydraulic cylinder, a first connecting lever and a second connecting lever. A hydraulic cylinder and the lateral pressing cylinder act to drive an upper die, a left male die and a right male die to move to a lower die on the workbench for pressing. The driving mechanism drives the toggle lever mechanism to move the sliding block, the sliding block is fast in a return downward trip, and a working stroke is slow and stable; in addition, in the working stroke, the stamping pressure has long duration, the pressing efficiency is high, the stress bearing effect of the rack is good, so that the installed power is reduced and the production cost is lowered.

The invention relates to a forging and moulding die for a composite insulator ball socket fitting. The forging and moulding die is characterized by comprising an upper die plate, a convex die, movable die holders, a fixed die holder, a lower die holder and a demoulding mandril, wherein the convex die is arranged on the upper die plate; a left die core and a right die core are respectively arranged on the left movable die holder and the right movable die holder, and the left die core and the right die core are assembled to form a cavity for accommodating the ball socket fitting; the fixed die holder is fixed on the lower die plate, an inner cavity is formed in the center of the fixed die holder, the left movable die holder and the right movable die holder are arranged in the inner cavity of the fixed die holder, and the left movable die holder and the right movable die holder are matched with the side wall of the inner cavity of the fixed die holder through a guide structure, wherein the upper end of the guide structure inclines outwards. In the compression process, a ball socket fitting blank is subjected to pre-forging and trimming and then put in the die cores, the convex die moves downwards, and a ball socket is subjected to once compression moulding in the die cores; in the demoulding process, a demoulding cylinder jacks upwards, the die cores move upwards along with the left movable die holder and the right movable die holder, so that the demoulding is realized; and the forging and moulding die is high in compression efficiency, and the manufactured ball socket fitting is low in rejection rate.

The present invention relates to a novel aging-resistant aerosol generating agent and preparation method thereof. The aging-resistant aerosol generating agent in the present invention comprises oxidizer, reducer and bonding agent, wherein the oxidizer is potassium nitrate, the bonding agent is phenolic resin, and the reducer is melamine; the weight percentages of the three constituents are: potassium nitrate: 60˜80%, phenolic resin: 8˜15%, and melamine: the rest. In the preparation process, phenolic resin is dissolved in ethanol to give phenolic resin solution at concentration by 40˜50 wt %; the oxidizer and reducer are pulverized, mixed, and then the phenolic resin solution is added to the mixed powder; next, the mixture is agitated, pelletized, dried, and shaped by pressure molding. Compared to that in the prior art, the aerosol generating agent in the present invention has higher fire suppression efficiency and higher fire suppression rate, and greatly improved aging resistant performance.

A liquid discharging method for a liquid head discharge head, which is provided with a plurality of discharge ports for discharging liquid, a plurality of liquid flow paths communicated always with each of the discharge ports at one end, each having bubble generating area for creating bubble in liquid, bubble generating means for generating energy to create and grow the bubble, a plurality of liquid supply ports each arranged for each of the liquid flow paths to be communicated with common liquid supply chamber, and movable member supported with minute gap to the liquid supply port on the liquid flow path side, and provided with free end, the area of the movable member surrounded at least by the free end portion and both sides continued therefrom being made larger than the opening area of the liquid supply port facing the liquid flow path, comprises the step of setting a period for the movable member to close and essentially cut off the opening area during the period from the application of driving voltage to the bubble generating means to the substantial termination of isotropical growth of the entire bubble by the bubble generating means, hence making it possible to enhance the suppressing efficiency of the bubble growing component in the direction opposite to the discharge port, and the refilling characteristics of liquid simultaneously.

The invention discloses an environmentally-friendly building material manufacturing extrusion forming device, and relates to the technical field of environmentally-friendly building materials. The environmentally-friendly building material manufacturing extrusion forming device comprises a stirring box. A sleeve is vertically arranged on the stirring box in a rotating mode, and a stirring shaft which is connected through a connecting mechanism is installed in the sleeve in a rotating mode. A lifting mechanism is connected with a compression cylinder through a conveying pipe, a press mechanismwhich is used for extruding raw materials is arranged on the compression cylinder, and a limiting mechanism is arranged on the compression cylinder. According to the environmentally-friendly buildingmaterial manufacturing extrusion forming device, the connecting mechanism is driven by an arranged double-shaft motor, a stirring frame and stirring blades rotate in the opposite directions, and therefore the raw materials inside the stirring box are fully stirred and mixed; an arranged circulating mechanism can upwards lift the raw materials at the bottom of the interior of the stirring box, andtherefore the raw materials can be repeatedly subjected to the stirring effects of the stirring frame and the stirring blades, the stirring and mixing effect is better, and stirring operation is comprehensive and full; and the arranged press mechanism can achieve the effect that the raw materials in the compression cylinder are automatically pressed, and the effect that the raw blank materials ofan environmentally-friendly building material are efficiently pressed is achieved.

The invention relates to construction and screening as well as applications for a siRNA expression carrier of a stomach cancer target STAT3 gene. Two expression plasmids STAT3-siRNA1/2 in mammal cells for expressing siRNA are constructed by mainly utilizing an RNA interference technology aiming at different target sequences of an STAT3 gene. The siRNAs expression carrier of the stomach cancer target STAT3 gene provided by the invention can inhibit STAT3 gene expression efficiently with specificity, and can be used for preparing gene medicaments for treating high-expression STAT3 gene stomach cancer.

The invention discloses small-interfering RNA (siRNA) capable of inhibiting classical swine fever virus (CSFV) reproduction and infection as well as an encoding sequence thereof. The invention also discloses a method for preparing an anti-CSFV infection biological preparation using an RNA-interfering method. The siRNA is efficient and can specifically inhibit CSFV. The method is applicable to industrial production. The invention also provides a biological preparation produced by using the method. The biological preparation has the CSFV inhibition ratio of 95.04-98.59%, and can distinctly inhibit CSFV infection in sensitive animals, so as to prevent incidence and death of animals.

The invention discloses application of a water-soluble fullerene structure in preparation of a medicine for treating tumors. The water-soluble fullerene structure comprises water-soluble hollow fullerene and at least one of pharmaceutical salts and pharmaceutical esters thereof. The medicine has the beneficial effects that the affinity to organisms is good, the toxicity is low, the tumor inhibiting efficiency is high and the tumor treating effect is good.

The invention belongs to the field of antimicrobial peptides, and discloses an antimicrobial peptide based on a cell penetrating peptide Tat (49-57) and a synthetic method of the antimicrobial peptide. The antimicrobial peptide is Tat (YG), Tat (YY), Tat (FG) or Tat (FF), and a sequence of a peptide chain is successively as shown by SEQ ID No. 2 to No. 5. The antimicrobial peptide is synthesized by adopting Wang resin as a carrier, adopting Fmoc as an amino acid side chain protection base, adopting a DMF solution of piperidine as a deprotection reagent and adopting HBTU, HOBT and DIEA as amino acid condensing agents in a solid-phase synthetic method. The four derivative antimicrobial peptides have good inhibition efficiency for escherichia coli, salmonella typhimurium, Bacillus subtilis and staphylococcus aureus, and the inhibition rate for some bacteria can be higher than that of the cell penetrating peptide Tat (49-57); and moreover, the hemolytic activity of the four derivative microbial peptides is small, and the concentration when the bacteriostatic activity is played cannot reach the lowest hemolytic concentration.

The present invention relates to red tide and algalbloom preventing and controlling technology, and is especially method of adopting glycolipid surfactant in treating red tide of sea water and algalbloom of fresh water. The effective component of the biological surfactant is sophor glycolipid as one kind of mixture comprising one acid type matter and one lactone type matter. It may be used alone to inhibit and kill harmful alga and crack their cells effectively and the effective concentration for eliminating alga in different kinds is 5-10 mg/l. It may be also used through mixing with clay mineral to raise the flocculant efficiency organic clay mineral obviously, and the optimal mixing weight ratio to loess is 1 to 100-200. The present invention has easy biodegradation, no harm to other life beings, no secondary pollution and easy storing.

Construction for constructing and screening siRNAs expression carrier of stomach cancer target AFP gene and its use are disclosed. Three expression plasmids in mammal cells by different AFP gene target sequences are constructed, and they are pSIREN-DNR-DsRed-Express Donor-Vector-AFP-siRNA1; pSIREN-DNR-DsRed-Express Donor Vector-AFP-siRNA2 and pSIREN-DNR-DsRed-express Donor Vector-AFP-siRNA3. It can inhibit AFP gene expression efficiently and be used to prepare gene medicine in treatment of stomach cancer.

The invention provides an environment-friendly water permeable brick as well as a compression forming mould and a preparation method for preparing the environment-friendly water permeable brick. The water permeable brick is formed by a water permeable brick surface layer and a water permeable brick base layer, wherein materials of the surface layer mainly comprise sand with the particle size being 10 to 20 mesh and cement; materials of the base layer mainly comprise large gravel with the particle size being 3 to 8mm and cement. The method specifically the steps of adding the materials into two stirring machines respectively, adding other materials of corresponding formulas for evenly stirring, then compressing by a brick compression forming machine, distributing the base layer materials twice and the surface layer materials once in a lower mould hollow part of the compression forming mould, performing shaking compression for 2 to 3s after each time of material distribution, thus preparing a formed green brick, and then performing curing to form the water permeable brick. A dry-press forming process is adopted to prepare the water permeable brick, so that the production cost and the energy consumption are reduced; the prepared water permeable brick has good water permeability, abrasion performance, skid resistance and crushing resistance.

The invention relates to a multi-epitope artificial antigen of plasmodium falciparum and an application thereof. The invention designs a polynucleotide with a sequence as shown in SEQ ID No:1 and a polypeptide with a sequence as shown in SEQ ID No:2, wherein the polynucleotide and the polypeptide are used as artificial antigens to prepare vaccines, and antibodies can be obtained from the antigens and are used to prepare immune preparations against plasmodium falciparum infections and kits for detecting malaria infections. Compared with anti plasmodium falciparum vaccines in the prior art, the multi-epitope artificial antigen of the invention has high immunogenicity and antigen recognition diversity, and the antibody of the invention has high inhibition efficiency on the in vitro growth of plasmodium falciparum.

The invention discloses a static target restraining method for a ground surveillance radar system. The static target restraining method for the ground surveillance radar system comprises the steps that processed target detection information of the front end of a radar is obtained; interframe accumulation processing is carried out on the target detection information, and a two-dimensional image isformed according to the target detection information after the accumulation; edge extraction is carried out on the two-dimensional image, and target detection information which belongs to a same target after the extraction is obtained; static target area judgment processing is carried out on the target detection information which belongs to the same target, and a static target area range is markedout; and restraining processing is carried out on the target detection information in the static target area range, and target detection information after the static target restraining is obtained. According to the static target restraining method for the ground surveillance radar system, the problem that the ground surveillance radar system cannot accurately mark off the static target area due to variation of detection scenes and erecting sites is solved, the restraining speed of a static target and the detection precision of a moving target are improved, and a reliable data foundation is provided for subsequent track processing.

The invention discloses an application of water-soluble fullerene nanoparticles in preparing medicine for inhibiting tumor growth. The water-soluble fullerene nanoparticles comprise at least one of water-soluble hollow fullerene nanoparticles, pharmaceutically acceptable salts of the water-soluble hollow fullerene nanoparticles, pharmaceutically acceptable esters of the water-soluble hollow fullerene nanoparticles, water-soluble metal fullerene nanoparticles, pharmaceutically acceptable salts of the water-soluble metal fullerene nanoparticles, and pharmaceutically acceptable esters of the water-soluble metal fullerene nanoparticles. The drug has good affinity to organisms, low toxicity and high inhibition efficiency to on tumors.

A hand-held aerosol fire suppression apparatus comprises an outer cylinder, inner cylinder components, a handle, and an activation device, wherein each outer cylinder is provided with at least three inner cylinder components. Compared with the prior art, the present invention has the following advantages: 1. the outer cylinder is provided with three or more inner cylinder components, so as to achieve a large ejecting area, a high fire suppression efficiency, and safety in use; 2. The members of the inner cylinder component are assembled together as one component, so as to achieve a convenient assembly and a high production efficiency.