The invention relates to a special compound feed capable of promoting the growth and resisting the high-temperature stress of megalobrama amblycephala and a preparation method of the special compound feed, and belongs to the technical field of compound feeds for aquatic products. The preparation method comprises the following steps of firstly crushing fish meal, soybean meal, rapeseeds, cottonseed meal, DDGS, wheat, rice bran and bran for the first time through a crushing machine, and mixing the crushed fish meal, the crushed soybean meal, the crushed rapeseeds, the crushed cottonseed meal, the crushed DDGS, the crushed wheat, the crushed rice bran and the crushed bran so as to obtain a mixture A; then uniformly mixing the mixture A, soybean oil, flaxseed oil, fish oil, phosphatide oil, a conventional aquatic product compound premix, calcium dihydrogen phosphate, vitamin C, vitamin E, chromium picolinate and choline chloride so as to obtain a mixture B, and crushing the mixture B for the second time; and granulating the crushed mixture B so as to obtain granules, cooling the granules, and packaging the cooled granules. The feed prepared by the preparation method disclosed by the invention can promote the growth of the megalobrama amblycephala and can improve the capacity of the megalobrama amblycephala for resisting the high-temperature stress, the megalobrama amblycephala breeding benefits are increased, and assistance is provided for the healthy and sustainable development of the megalobrama amblycephala feed and the breeding industry.