Iseganan quick-release film agent

A technology of esgenan and film formulations, applied in the field of immediate release film formulations, to achieve the effects of good taste, strong tolerance, and not easy to be decomposed by protease

Active Publication Date: 2015-04-08
成都山信药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no research on the preparation of Esthergnan into immediate-release film

Method used

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  • Iseganan quick-release film agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 The preparation of quick-release film of the present invention (each embodiment prescription is as the criterion with Table 1)

[0028] Immediate Release Film Prescription

[0029] Estherglam 0.03% Glycerin 14% Polyethylene Glycol 8% Sorbic Acid 0.2%

[0030] Xylitol 0.4%, Strawberry Flavor 0.4%, Mannitol 8%, Microcrystalline Cellulose 16%

[0031] Tween 80 0.01% PVA05-88 24% HPMC 24%

[0032] The balance is phosphate buffer (PH6.8)

[0033] Preparation method:

[0034] 1. Soak PVA05-88 in enough buffer solution to make it fully swell, heat the fully swollen PVA05-88 at 65°C-80°C for 2 hours to dissolve, and filter;

[0035] 2. Mixing: Slowly add other excipients except the flavoring agent into the dissolved PVA05-88, stir while adding, then add the flavoring agent and stir slowly until the solution cools to 40-44°C, then gradually add the Segnam, stirring while adding;

[0036] 3. Add buffer solution to make a sufficient amount, and stir well to make...

Embodiment 2

[0037] Embodiment 2 The preparation of quick-release film agent of the present invention

[0038] Immediate Release Film Prescription

[0039] Estherglam 0.03% Glycerin 8% Macrogol 8% Xylitol 0.2%

[0040] Mannitol 8% Silicon Dioxide 8% Calcium Carbonate 8% Tween 80 0.02%

[0041] Soy Lecithin 2% PVA05-88 12% HPMC 30%

[0042] The balance is phosphate buffer (PH6.8)

[0043] The preparation method is the same as in Example 1.

Embodiment 3

[0044] Embodiment 3 The preparation of quick-release film agent of the present invention

[0045] Immediate Release Film Prescription

[0046] Estherglam 0.03% Macrogol 8% Sorbic Acid 0.2%

[0047] Xylitol 0.6% Peppermint 1.7% Mannitol 4% Microcrystalline Cellulose 8%

[0048] Tween 80 0.32% PVA05-88 12% PVA17-88 24%

[0049] HPMC 36% balance is phosphate buffer (PH6.8)

[0050] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention provides an iseganan quick-release film agent. The film agent is prepared from the following raw materials in percentage by weight: 0.001-0.3 percent of iseganan, 30-80 percent of a film forming agent, 0.01-9 percent of plasticizer, 0.2-3.0 percent of a flavoring agent, 0.02-0.5 percent of surfactant, 0-20 percent of filler and the balance of a buffer solution. The quick-release film agent can be quickly released in 1 minute, so that antimicrobial peptide can quickly reach high concentration in an administration position, and the bacterium resisting and inhibiting effect can be effectively achieved.

Description

technical field [0001] The present invention relates to an immediate-release film preparation of Estherginam. Background technique [0002] Amino acid sequence H-Arg-Gly-Gly-Leu-Cys-Tyr-Cys-Arg-Gly-Arg-Phe-Cys-Val-Cys- Val-Gly-Arg-NH2 (5-14,7-12; disulfide bond), the molecular formula is C 78 h 126 N 30 o 18 S 4 , with a molecular weight of 1900.29 Iseganan is an analogue of porcine neutrophil peptide-1 (protegrin-1, PG-1), which can combine with bacterial extracellular components such as lipopolysaccharide or lipid membrane acid to cause bacterial swelling and rupture , kills bacteria by disrupting cell membranes. [0003] Due to its unique mechanism of action, Eserginan has broad-spectrum bactericidal properties against oral microorganisms, does not produce drug resistance, has no toxic and side effects, and has the potential to replace traditional antibiotics. In vitro studies have shown that it has inhibitory effects on Gram-positive and negative bacteria and fung...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K38/10A61P31/04A61P1/02A61P17/02
Inventor 林山叶玉娇
Owner 成都山信药业有限公司
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