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47 results about "Protegrin" patented technology
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Protegrins are small peptides containing 16-18 amino acid residues. Protegrins were first discovered in porcine leukocytes and were found to have antimicrobial activity against bacteria, fungi, and some enveloped viruses. The amino acid composition of protegrins contains six positively charged arginine residues and four cysteine residues. Their secondary structure is classified as cysteine-rich β-sheet antimicrobial peptides, AMPs, that display limited sequence similarity to certain defensins and tachyplesins. In solution, the peptides fold to form an anti-parallel β-strand with the structure stabilized by two cysteine bridges formed among the four cysteine residues. Recent studies suggest that protegrins can bind to lipopolysaccharide, a property that may help them to insert into the membranes of gram-negative bacteria and permeabilize them.
Fibrillation resistant proteins
ActiveUS20090304814A1Improve the immunityIncreased susceptibilityBiocideFungiFibrillationHistidine residue
Protection of proteins against fibrillation may be afforded by introduction of certain histidine substitutions into the protein, such that a pair of histidines are present with sufficient spacing as to allow the histidines to coordinate with zinc. In the case of insulin, introduction of histidine residue substitutions at residues A4 and A8 together or a histidine residue substitution at residue B1, provides increased resistance to fibrillation while maintaining at least a majority of the activity of the insulin analogue. Introduction of a histidine residue substitution at residue A8 restores at least a portion of fibrillation resistance that may have been harmed by substitutions present on the B-chain such as those present in fast-acting insulins. Proteins protected by such histidine substitutions may be used to provide a pharmaceutical composition. A method of treating a patient includes administering a physiologically effective amount of the pharmaceutical composition to the patient.
Owner:CASE WESTERN RESERVE UNIV
Threonine-containing protegrins
InactiveUS6043220AInhibit microbial growthGrowth of microbeAntibacterial agentsBiocideDiseaseMedicine
The invention is directed to antimicrobial peptides related to naturally-occurring protegrin peptides, and methods of using the peptides in a variety of contexts, including the treatment or prevention of infections, and diseases related thereto.
Owner:RGT UNIV OF CALIFORNIA
Control of viral and bacterial infection by antimicrobial peptides retrocylin and/or protegrin expressed in chloroplasts
InactiveUS20110302675A1Process stabilityEasy to integrateAntibacterial agentsBiocideMicroorganismProtegrin
Disclosed herein are antimicrobial compositions containing one or more antimicrobial peptides having been expressed in chloroplasts. Exemplified herein are the expression and use of retrocylin and protegrin. Disclosed herein are methods of engineering chloroplasts to express such antimicrobial peptides such that they are properly processed and active. Plants containing such chloroplasts are disclosed as well. The chloroplast expressed peptides are useful to delay, prevent or treat viral and bacterial infections.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
Neurotoxin formulation
The invention relates to stable liquid neurotoxin formulations which are free of animal proteins, comprising a surfactant, an amino acid selected from tryptophan and tyrosine, a buffer comprising sodium, chloride and phosphate ions, which have a pH between 5.5 and 8, and which are stable for 2 months. These compositions are suitable for use in therapy and in particular for administration to a patient to achieve a desired therapeutic or aesthetic effect. The invention also relates to the use of an amino acid selected from tryptophan and tyrosine to protect a proteinaceous neurotoxin from degradation in a liquid composition which is free of animal derived proteins.
Owner:IPSEN BIOPHARM LTD
Xylanase-m with high heat stability and its coding gene and application thereof
ActiveCN109652393AImprove thermal stabilityImprove practicalityHydrolasesFermentationXylanaseC-terminus
The invention discloses xylanase-m with high heat stability and its coding gene and an application thereof. The protein provided by the present invention is named as xylanase-m, also known as xylanase-m protein, which is as follows (a1), (a2) or (a3): (a1) a protein consisting of 11st to 235th amino acid residues in SEQ ID NO: 1 of a sequence table; (a2) a protein represented by SEQ ID NO: 1 of the sequence table; and (a3) a fusion protein obtained by connecting a label at the N-terminus or / and C-terminus of (a1). The invention also provides an application of xylanase-m protein as xylanase. The invention also provides an application of xylanase-m protein in degrading xylan. The invention also provides an application of the xylanase-m protein in reducing sugar production by taking xylan asa substrate. The xylanase-m can be used in the food industry, animal feed industry and paper bleaching industry, and has great application value.
Owner:INST OF MICROBIOLOGY - CHINESE ACAD OF SCI
Protegrin-1 antimicrobial peptide derivative and preparation method and application thereof
InactiveCN106518973AEasy to synthesizeLow costAntibacterial agentsOrganic active ingredientsCyclaseProteinase activity
The invention provides a Protegrin-1 antimicrobial peptide derivative and a preparation method and application thereof. The preparation method of the Protegrin-1 antimicrobial peptide derivative comprises the steps that linear polypeptide is synthesized; the linear polypeptide is synthesized into cyclase polypeptide, the Cys in the fifth position and the fourth position and the Cys in the seventh position and the twelfth position of the amino acid sequence in the cyclase polypeptide form two pairs of disulfide bonds. According to the Protegrin-1 antimicrobial peptide derivative and the preparation method and the application thereof, molecule improvement is performed on the Protegrin-1 antimicrobial peptide by replacing amino acid in corresponding positions, the antibacterial peptide derivative which is high in antibacterial activity, low in hemolytic activity and more stable in protease is screened by a lot of activity experiments, the artificial synthesis of the group of antibacterial peptides is simple and the cost is lower, the derivative is beneficial for industrial production, and excellent candidate peptides are provided for the research and development of novel antibacterial agents.
Owner:成都山信药业有限公司 +1
Application of antimicrobial peptide Protegrin-1 for preventing and controlling porcine reproductive and respiratory syndrome
InactiveCN103623391AGood antiviral effectPowder deliveryPeptide/protein ingredientsEscherichia coliAntimikrobielle peptide
The invention belongs to the technical field of medicines, and in particular discloses application of an antimicrobial peptide Protegrin-1 for preventing and controlling porcine reproductive and respiratory syndrome. According to the invention, an antimicrobial peptide Protegrin-1 is chemically synthesized according to an amino acid sequence of reported Protegrin-1 firstly; then, antimicrobial activity of the antimicrobial peptide Protegrin-1 is proved through an escherichia coli resistant DH5 alpha experiment, and researches on the antivirus activity of the antimicrobial peptide to HP-PRRSV are made through qRT-PCR, Western-Blot, cell supernatant TCID50 detection, IFA and other methods; and further the antivirus mechanism of the antimicrobial peptide is explained in virus adsorption and entrance into cell processes. The antimicrobial peptide Protegrin-1 is expected to be used as a novel medicine for preventing and controlling porcine reproductive and respiratory syndrome.
Owner:SUN YAT SEN UNIV
L-asparaginase XiDL and coding gene and application thereof
ActiveCN110256535AIncrease enzyme activityWide range of reaction pHPeptide/protein ingredientsHydrolasesFood industryAcute lymphocytic leukemia
The invention discloses L-asparaginase XiDL and a coding gene and application thereof. The protein, L-asparaginase XiDL, provided herein is originated from Xinfangfangia sp., and is named as XiDL protein, which is a protein composed of an amino acid sequence shown as a sequence 1 in a sequence table, or a protein composed of an amino acid sequence shown as a sequence 3 in the sequence table. Invention also claims application of the XiDL protein as L-asparaginase, as well as application of the XiDL protein in treatment of acute lymphocytic leukemia, lymphoid malignancies, Hodgkin lymphoma and the like. The invention also claims a preparation to prevent formation of acrylamide in oil-fried or baked foods, with the preparation having the XiDL protein as an active ingredient. The L-asparaginase XiDL has a major application prospect in the related medical field, food industry field and other fields.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)
Liquid neurotoxin formulation stabilized with tryptophan or tyrosine
The invention relates to stable liquid neurotoxin formulations which are free of animal proteins, comprising a surfactant, an amino acid selected from tryptophan and tyrosine, a buffer comprising sodium, chloride and phosphate ions, which have a pH between 5.5 and 8, and which are stable for 2 months. These compositions are suitable for use in therapy and in particular for administration to a patient to achieve a desired therapeutic or aesthetic effect. The invention also relates to the use of an amino acid selected from tryptophan and tyrosine to protect a proteinaceous neurotoxin from degradation in a liquid composition which is free of animal derived proteins.
Owner:IPSEN BIOPHARM LTD
Polymer conjugates of protegrin peptides
The invention provides protegrin that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention has enhanced half-life and / or reduced clearance.
Owner:NEKTAR THERAPEUTICS INC
Amidase XAM, and encoding gene and application thereof
ActiveCN111944794AIncrease enzyme activityBroad substrate spectrumHydrolasesFermentationChemical industryHydroxamic acid
The invention discloses amidase XAM, and an encoding gene and application thereof. The protein provided by the invention is from Xinfangfangia sp., is an amidase tag family amidase, is named XAM protein and is the protein having an amino acid sequence disclosed by a sequence 1 in a sequence table. The invention also provides application of the XAM protein as the amidase. The invention also provides application of the XAM protein in hydroxamic acid production. The invention has a great application prospect in relevant medical care fields, chemical industry fields and the like.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)
HCV (hepatitis C virus) cracking agent, preparation method thereof and HCV detection kit
PendingCN113552358ACracking is effectiveHigh sensitivityBiological material analysisBiological testingAntigenActive agent
The invention relates to the technical field of biological detection and particularly relates to an HCV (hepatitis C virus) cracking agent, a preparation method thereof and an HCV detection kit. The HCV virus cracking agent comprises an anionic surfactant, a nonionic surfactant, a protein settling agent, protective protein and a cleaning antibody, wherein the nonionic surfactant is N, N-dimethyl-N-(3-sulfopropyl)-1-octadecane ammonium inner salt. The HCV virus splitting agent can effectively split the virus and dissociate an antigen-antibody complex, so sensitivity of detecting the core antigen of the HCV virus is obviously improved, and the probability of illness state delay caused by leak detection in a window period is greatly reduced; the method has advantages of simplicity and rapidness in operation, low cost, high applicability and easiness in popularization and application.
Owner:AUTOBIO DIAGNOSTICS CO LTD
Application of Protegrin-1 antibacterial peptide derivative in preparation of drugs resisting oral pathogens
ActiveCN108524911AGood treatment effectClear efficacyAntibacterial agentsPeptide/protein ingredientsDiseaseOral disease
The invention provides application of a polypeptide in preparation of drugs resisting oral pathogens, wherein an amino acid sequence of the polypeptide is shown in any one of SEQ ID NO.1-SEQ ID NO.8.The invention further provides a drug resisting oral pathogens and application thereof. The Protegrin-1 antibacterial peptide derivative with a specific sequence can specially kill various oral pathogens, and can be used for treating and preventing oral diseases; and the prepared specific preparation is highly stable and can better treat oral diseases, thereby having a good application prospect.
Owner:成都山信药业有限公司
Application of antimicrobial peptide Protegrin-1 for preventing and controlling porcine reproductive and respiratory syndrome
InactiveCN103623391BGood antiviral effectPowder deliveryPeptide/protein ingredientsEscherichia coliAntimikrobielle peptide
The invention belongs to the technical field of medicines, and in particular discloses application of an antimicrobial peptide Protegrin-1 for preventing and controlling porcine reproductive and respiratory syndrome. According to the invention, an antimicrobial peptide Protegrin-1 is chemically synthesized according to an amino acid sequence of reported Protegrin-1 firstly; then, antimicrobial activity of the antimicrobial peptide Protegrin-1 is proved through an escherichia coli resistant DH5 alpha experiment, and researches on the antivirus activity of the antimicrobial peptide to HP-PRRSV are made through qRT-PCR, Western-Blot, cell supernatant TCID50 detection, IFA and other methods; and further the antivirus mechanism of the antimicrobial peptide is explained in virus adsorption and entrance into cell processes. The antimicrobial peptide Protegrin-1 is expected to be used as a novel medicine for preventing and controlling porcine reproductive and respiratory syndrome.
Owner:SUN YAT SEN UNIV
D-lactic dehydrogenase SaDLD as well as encoding gene and application thereof
The invention discloses D-lactic dehydrogenase SaDLD as well as an encoding gene and application thereof. The protein provided by the invention is derived fromSalinispirillum sp.JHis D-lactic dehydrogenase, is named as SaDLD protein, and is a protein consisting of an amino acid sequence as shown in a sequence 1 in a sequence table. The invention also protects the application of the SaDLD protein as the D-lactic dehydrogenase. The protein has great application prospects in the fields of related medicines, foods, cosmetics and the like.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)
Amidase xam and its encoding gene and application
ActiveCN111944794BIncrease enzyme activityBroad substrate spectrumHydrolasesGenetic engineeringChemical industryHydroxamic acid
The invention discloses amidase XAM and its coding gene and application. The protein provided by the present invention is derived from Xinfangfangia sp., is an amidase tag family amidase, named XAM protein, and is a protein composed of the amino acid sequence shown in Sequence 1 in the sequence listing. The invention also protects the use of XAM protein as amidase. The invention also protects the use of XAM protein in the production of hydroxamic acid. The present invention has great application prospects for related medical fields, chemical industry fields and the like.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)
Acetolactate synthase inhibitor resistance-related protein uvals and its coding gene and application
Owner:NORTHEAST AGRICULTURAL UNIVERSITY
Nitrilase XiNit2 and its coding gene and application thereof
ActiveCN110205315AHigh enzyme activityWide range of reaction temperatureBacteriaHydrolasesAgricultural scienceAmino acid
The present invention discloses a nitrilase XiNit2 and its encoding gene and an application thereof. The protein provided by the invention is derived from Xinfangfangia sp., is the nitrilase, designated as XiNit2 protein, and is the protein comprising an amino acid sequence shown in SEQ ID NO: 1 in a sequence table; and the protein comprising the amino acid sequence shown in SEQ ID NO: 3 in the sequence table. The invention also provides the application of the XiNit2 protein as the nitrilase. The present invention also provides a preparation for degrading a nitrile compound, and the active ingredient of which is the XiNit2 protein. The nitrilase XiNit2 has great application prospects for related chemical fields and environmental pollution control fields.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)
Amide hydrolase SaAH and coding gene and application thereof
The invention discloses amide hydrolase SaAH and a coding gene and application thereof. The protein provided by the invention is derived from Salinispirillum sp.JH (Salinispirillum sp.JH), is an amide hydrolase, is named SaAH protein, and is a protein consisting of an amino acid sequence shown as a sequence 1 in a sequence table. The invention also protects the application of the SaAH protein as the amide hydrolase.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)
Nitrilase xinit1 and its coding gene and application
InactiveCN110129304BIncrease enzyme activityImprove toleranceHydrolasesFermentationWAS PROTEINProtegrin
The invention discloses nitrilase XiNit1 and a coding gene and application thereof. Protein provided by the invention comes from Xinfangfangiasp, is nitrilase, is named as XiNit1 protein, is protein composed of an amino acid sequence shown as a sequence 1 in a sequence table and protein composed of an amino acid sequence shown as a sequence 3 in the sequence table. The invention further disclosesapplication of the XiNit1 protein as nitrilase and a preparation for degrading nitrile compounds. The XiNit1 protein serves as an active ingredient of the preparation. The nitrilase has great application prospect in the field of related chemical industry and the field of environment pollution control.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)
Alanine dehydrogenase SaAD as well as coding gene and application thereof
ActiveCN113637650AIncrease enzyme activityWide range of reaction temperatureBacteriaMicroorganism based processesFood industryProtegrin
The invention discloses alanine dehydrogenase SaAD as well as a coding gene and application thereof. The protein provided by the invention is derived from Salinispirillum sp.NM (Salinispirillum sp.NM), is alanine dehydrogenase, is named as an SaAD protein, and is a protein consisting of an amino acid sequence as shown in a sequence 1 in a sequence table. The invention also protects the application of the SaAD protein as alanine dehydrogenase. The invention has great application prospects in the fields of related medicines, food industry, health care and the like.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)
Application of Y-39983 HCl in preparation of antiviral drugs
PendingCN113171363AFree from degradationInhibit bindingOrganic active ingredientsAntiviralsAntiviral drugProtegrin
The invention relates to application of Y-39983HCl in antiviral drugs, and belongs to the field of drugs. According to the invention, the NanobiT technology finds that the Y-39983HCl has new functions of inhibition of binding of BST-2 and Vpu protein and inhibition of BST-2 protein degradation; the Y-39983HCl can be used for effectively inhibiting virus infection while protecting the BST-2 protein. The Y-39983HCl has a broad-spectrum inhibition effect on viruses with a BST-2 degradation function, and can be used for research and development of antiviral drugs.
Owner:BEIJING UNIV OF TECH
Application of GrpE protein or coding gene thereof as specific molecular target for resisting laodelphax striatellus and rice stripe virus
ActiveCN114573675ABlock the vertical propagation processBiocideDisinfectantsProtegrinRespiratory syndrome virus
The invention discloses application of a GrpE protein or an encoding gene thereof as a molecular target for specifically resisting laodelphax striatellus and rice stripe virus. The invention provides a protein, which is derived from Laodelphax striatellus, is named as LsGrpE protein, and is a protein shown as a sequence 1 in a sequence table. The gene for coding the LsGrpE protein is named as the LsGrpE gene and also belongs to the protection range of the invention. The invention also protects the application of the LsGrpE protein or the LsGrpE gene as a molecular target. The molecular target is an anti-laodelphax striatellus and / or anti-stripe virus molecular target. The LsGrpE can be used as an anti-laodelphax striatellus molecular target for preventing and treating laodelphax striatellus, and can indirectly prevent the vertical propagation process of RSV (Respiratory Syndrome Virus).
Owner:INST OF MICROBIOLOGY - CHINESE ACAD OF SCI
Use of protegrin-1 antimicrobial peptide derivatives in the preparation of anti-oral pathogenic bacteria drugs
ActiveCN108524911BGood treatment effectClear efficacyAntibacterial agentsPeptide/protein ingredientsMedicineProtegrin
The present invention provides the use of a polypeptide with an amino acid sequence as shown in any one of SEQ ID NO.1 to SEQ ID NO.8 in the preparation of drugs against oral pathogenic bacteria. The invention also provides a medicine against oral pathogenic bacteria and its application. The Protegrin-1 antimicrobial peptide derivatives of the specific sequence of the present invention can specifically kill various oral pathogenic bacteria, and can be used for the treatment and prevention of oral diseases, and the prepared specific preparation has strong stability and has a therapeutic effect on oral diseases. Better, good application prospects.
Owner:成都山信药业有限公司
L-asparaginase sala and its encoding gene and application
ActiveCN113549607BIncrease enzyme activityWide range of reaction temperatureBacteriaHydrolasesBiotechnologyProtegrin
The invention discloses L-asparaginase SaLA and its encoding gene and application. The protein provided by the present invention is derived from Salinispirillum sp. JH, is a L-asparaginase, named SaLA protein, and is a protein composed of the amino acid sequence shown in Sequence 1 in the sequence table. The present invention also protects the use of SaLA protein as L-asparaginase. The present invention has great application prospects in the related medical fields, food processing fields and the like.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)
Use of peptide vectors to improve the immune response to antigens
The invention relates to conjugates of an antigen coupled to a linear derivative of a β-stranded antibiotic peptide, which are useful for immunogenic agents to enhance a CTL response. Two groups of preferred peptides are derived from the antibiotics protegrin and tachyplesin.
Owner:SYNTEM SA
L-asparaginase SaLA and coding gene and application thereof
ActiveCN113549607AIncrease enzyme activityWide range of reaction temperatureBacteriaHydrolasesBiotechnologyProtegrin
The invention discloses L-asparaginase SaLA and a coding gene and application thereof A protein provided by the invention is derived from Salinispirillum sp.JH, is L-asparaginase, is named as the SaLA protein, and is a protein consisting of an amino acid sequence shown as a sequence 1 in a sequence table. The invention also protects the application of the SaLA protein as the L-asparaginase. The L-asparaginase SaLA has great application prospects in the related medical field, the food processing field and the like.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)
A kind of xylanase xylanase-m with high thermostability and its coding gene and application
ActiveCN109652393BImprove thermal stabilityImprove practicalityHydrolasesFermentationFood industryXylan
The invention discloses xylanase-m with high heat stability and its coding gene and an application thereof. The protein provided by the present invention is named as xylanase-m, also known as xylanase-m protein, which is as follows (a1), (a2) or (a3): (a1) a protein consisting of 11st to 235th amino acid residues in SEQ ID NO: 1 of a sequence table; (a2) a protein represented by SEQ ID NO: 1 of the sequence table; and (a3) a fusion protein obtained by connecting a label at the N-terminus or / and C-terminus of (a1). The invention also provides an application of xylanase-m protein as xylanase. The invention also provides an application of xylanase-m protein in degrading xylan. The invention also provides an application of the xylanase-m protein in reducing sugar production by taking xylan asa substrate. The xylanase-m can be used in the food industry, animal feed industry and paper bleaching industry, and has great application value.
Owner:INST OF MICROBIOLOGY - CHINESE ACAD OF SCI
Polymer conjugates of protegrin peptides
The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
Owner:NEKTAR THERAPEUTICS INC
HaHSP4 protein of cereal cyst nematode and coding gene and application thereof
The invention discloses a HaHSP4 protein of cereal cyst nematode and a coding gene and application thereof. The protein is obtained from the cereal cyst nematode and named the HaHSP4 protein which isthe protein consisting of the amino acid sequence shown in SEQ ID NO:1 in the Sequence Listing. A gene encoding the HaHSP4 protein is named the HaHSP4 gene, and also belongs to the scope of the invention. The invention also provides the application of the HaHSP4 protein. The application includes regulating the host tropism of the cyst nematode; regulating the parasitic capability of the cyst nematode; regulating the pathogenic capability of the cyst nematode; regulating the development of the cyst nematode. The invention also provides a method for cultivating a plant with improved resistance to the cyst nematode. The method comprises the steps of introducing a substance inhibiting the expression of the HaHSP4 protein into a target plant to obtain the plant with the improved resistance to the cyst nematode. The protein has great value for research on the pathogenic mechanism of the cyst nematode and the preparation of anti-nematode plants.
Owner:CHINA AGRI UNIV
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