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Application of Y-39983 HCl in preparation of antiviral drugs

A technology of y-39983hcl and 1.y-39983hcl is applied in the application field of antiviral drugs to achieve the effect of broad-spectrum inhibition

Pending Publication Date: 2021-07-27
BEIJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the above urgent need for broad-spectrum specific antiviral drugs, the application provides an application of Y-39983HCl in the preparation of antiviral drugs

Method used

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  • Application of Y-39983 HCl in preparation of antiviral drugs
  • Application of Y-39983 HCl in preparation of antiviral drugs
  • Application of Y-39983 HCl in preparation of antiviral drugs

Examples

Experimental program
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Effect test

Embodiment 1

[0025] 1.1 Cells and plasmids

[0026] HEK293T cells, TZM-bl cells, and Hela cells were all preserved by our laboratory. The NanobiT vector was purchased from Promega, and the pseudovirus packaging plasmids 11051 and 11035 were preserved by our laboratory.

[0027] 1.2 Main reagents

[0028] Y-39983 HCl used in in vitro experiments was purchased from Selleck Chemicals, with a purity of >99%.

[0029] 1.3 Y-39983 HCl Toxicity Test

[0030] In order to detect the toxicity of compound Y-39983 HCl, compound Y-39983 HCl was added to HEK293T cells at a final concentration of 0 μmol / L-50 μmol / L. 48 hours after treatment, cell viability was detected using CCK-8. The relative cell viability was calculated as the percentage of DMSO-treated control cells. IC50 values ​​of drugs were calculated using GraphPad Prism 8.0 software. Such as figure 1 It is shown that when the drug is calculated by the activity of the cells at 6.25 μM, the inhibition rate of the cell activity is 21.2%. ...

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Abstract

The invention relates to application of Y-39983HCl in antiviral drugs, and belongs to the field of drugs. According to the invention, the NanobiT technology finds that the Y-39983HCl has new functions of inhibition of binding of BST-2 and Vpu protein and inhibition of BST-2 protein degradation; the Y-39983HCl can be used for effectively inhibiting virus infection while protecting the BST-2 protein. The Y-39983HCl has a broad-spectrum inhibition effect on viruses with a BST-2 degradation function, and can be used for research and development of antiviral drugs.

Description

technical field [0001] The invention relates to the field of biotechnology, especially the application of Y-39983 HCl in antiviral drugs Background technique [0002] AIDS is a malignant infectious disease caused by human immunodeficiency virus (HIV) infecting CD4+ T cells, leading to the destruction of immune function, and then leading to opportunistic infections and tumors. Drugs currently approved for marketing mainly target viral proteins in each cycle of the virus, including fusion inhibitors (FIs), nucleoside and non-nucleoside reverse transcriptase inhibitors, protease inhibitors, and integrase inhibitors. Although the mortality and morbidity of patients have been significantly reduced by continuous optimization of combined antiretroviral therapy (cART), patients may still stop treatment due to dependence, adverse drug reactions, and limited economic level. Therefore, it is necessary to find new targets for antiviral therapy, establish an efficient and feasible activ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/437A61P31/12A61P31/14A61P31/16A61P31/18
CPCA61K31/437A61P31/12A61P31/14A61P31/16A61P31/18
Inventor 李博野胡秦董晓筱陈天于渤洋
Owner BEIJING UNIV OF TECH
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