NP10 antibacterial peptide film preparation and preparing method and application thereof

Abstract

The invention provides an NP10 antibacterial peptide film preparation and a preparing method and an application thereof, and belongs to the technical field of medical dressing. The NP10 antibacterialpeptide film preparation is prepared by electrostatic spinning of an electrospinning solution including chitosan, polyethylene oxide, NP10 antibacterial peptide, acetic acid and distilled water. In the electrospinning solution, the concentration of chitosan is 1%-2% w / v, the concentration of polyethylene oxide is 1%-2% w / v, the concentration of thantibacterial peptide is 0.1%-0.5% w / v and the concentration of acetic acid is 1%-2% v / v. The NP10 antibacterial peptide film preparation has the advantages of soft texture, excellent antibacterial effect, good biocompatibility, biodegradability, andgood drug release performance, is not easy to cause exogenous infection, and has low cost.

Description

technical field [0001] The invention belongs to the technical field of medical dressings, and in particular relates to an NP10 antimicrobial peptide film preparation and a preparation method and application thereof. Background technique [0002] Bacteria, the most abundant form of life on Earth, form a bacterial infection when they invade the human body in a harmful manner and successfully reproduce. Bacterial infections are somewhat contagious and can occur in different parts of the human body and in varying degrees of severity, from the epidermis to deep tissues, from mild infections to fatal inflammations. Infection is undoubtedly one of the direct causes of difficult-to-heal ulcers, amputation and even death in diabetic foot ulcers. Wound infections caused by extensive burns also urgently need antibacterial dressings to suppress bacterial infections. If the invading bacteria are not removed in the first place or not properly treated, persistent infection will occur, an...

AI Technical Summary

Problems solved by technology

Antibiotics have the advantages of fast drug effect and strong bactericidal ability, but at the same time of sterilization, bacteria gradually develop resistance to antibiotics, which leads to the continuous weakening of the therapeutic effect of antibiotics

Many inorganic metals and their compounds are used to prepare antibacterial electrospun wound dressings, among which metallic silver is the most widely studied type of inorganic antibacterial agents, including silver chloride, silver sulfadiazine, silver nitrate and other silver compounds, etc. Silver antibacterial agents have the advantages of good heat resistance, broad-spectrum antibacterial and low drug resistance, but there are also many defects at the same time, such as harsh preparation conditions for nano-silver particles, complicated process, high cost, and heavy metal ions are easy to cause environmental pollution. Pollution, etc.

In short, traditional antibacterial dressings have small porosity and specific surface area, poor dressing barrier effect, easy to cause exogenous infection, poor antibacterial effect, and expensive

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