Vaccine adjuvant and preparation method thereof

Abstract

The invention discloses a vaccine adjuvant and a preparation method thereof. The vaccine adjuvant is prepared from the following components in parts by weight: water for injection, liposome, Tween-80,white oil for injection, resiquimod and Span-80. The liposome can be subjected to intramuscular injection to generate an antigen slow-release effect, and the liposome can guide antigens to antigen presenting cells to enhance the immune response of the organism. The resiquimod can promote the maturity of dendritic cells and enhance the immune response of cells and body fluid. The resiquimod playsroles depending on injection, is distributed in the whole body, is shortened in half-life period in vivo, and can not well cause adaptive immune reaction. The liposome is favorable for enabling activecomponents to pass through physiological and cellular barriers and has the advantages of enabling medicines to be targeted to the reticuloendothelial system, enhancing the medicinal effect and the like. When the liposome, the resiquimod and immunogen are used together, adaptive immune reaction caused by the resiquimod can be improved; and when the liposome and the resiquimod cooperate together, innate immune reaction can be excited, synergistic interaction can be realized, and the immune response of the organism can be improved.

Description

technical field [0001] The invention relates to the field of biomedicine, more specifically, to a vaccine adjuvant and a preparation method thereof. Background technique [0002] The purpose of immunization is to induce the body to produce a strong immune response to the vaccination antigen, so as to protect the body from the invasion of corresponding pathogens. For this purpose, inactivated vaccines require the assistance of an adjuvant in contrast to attenuated vaccines. Adjuvant, also known as vaccine modulator or vaccine enhancer, is an additive to a vaccine. When it is injected into the body before or mixed with the antigen, it can enhance the body’s immune response to the antigen or change the type of immune response. Enhancer of non-specific immunity, which itself has no antigenicity. [0003] The Chinese patent with publication number CN101428145A discloses a nanoparticle adjuvant. The composition of the adjuvant contains mineral oil, a surfactant, and an immune en...

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Problems solved by technology

[0004] This adjuvant fully emulsifies the raw materials in the adjuvant through a surfactant, and enhances the immune response through an immune enhancer, but the way this adjuvant enhances the immune response is relatively single, and the enhancement effect is poor, which needs to be improved

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