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A kind of vaccine adjuvant and preparation method thereof

A vaccine adjuvant and adjuvant technology, applied in the field of biomedicine, can solve the problems of single immune response enhancement method and poor enhancement effect, and achieve the effect of retaining the activity of immune adjuvant, overcoming hemolysis, and improving immune response

Active Publication Date: 2021-11-09
浙江洪晟生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] This adjuvant fully emulsifies the raw materials in the adjuvant through a surfactant, and enhances the immune response through an immune enhancer, but the way this adjuvant enhances the immune response is relatively single, and the enhancement effect is poor, which needs to be improved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: A vaccine adjuvant, the components and parts by weight in the raw materials are shown in Table 1. A kind of preparation method of vaccine adjuvant comprises the following steps:

[0030] Step 1, preparation of the adjuvant aqueous phase: adding liposomes and Tween-80 to the water for injection, stirring thoroughly;

[0031] Step 2, preparation of the adjuvant oil phase: add Resimod and Span-80 into the white oil for injection, and stir thoroughly;

[0032] Step 3, adding the adjuvant oil phase to fully emulsify during the process of stirring the adjuvant water phase to obtain a standby emulsion;

[0033] Step 4, using a high-pressure homogenizer to perform nano-treatment on the standby emulsion to obtain a nano-emulsion;

[0034] In step 5, the nanoemulsion is sterilized by filtration using a 0.2 μm microporous membrane.

Embodiment 2

[0035] Embodiment 2: A vaccine adjuvant. The difference from Embodiment 1 is that the components and parts by weight in the raw materials are as shown in Table 1.

Embodiment 3

[0036] Embodiment 3: A vaccine adjuvant. The difference from Embodiment 1 is that the components and parts by weight in the raw materials are shown in Table 1.

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PUM

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Abstract

The invention discloses a vaccine adjuvant and a preparation method thereof. The raw materials include the following components in parts by weight: water for injection, liposome, Tween-80, white oil for injection, resimod, and Disc‑80. Intramuscular injection of liposomes produces a slow-release effect of antigens, and liposomes can guide antigens to antigen-presenting cells and enhance the body's immune response. Resimod can promote dendritic cell maturation and enhance cellular and humoral immune responses. Resimod relies on injection to function, is distributed throughout the body, has a shorter half-life in the body, and cannot well induce adaptive immune responses. Liposomes are beneficial for active ingredients to cross physiological and cellular barriers, and have the advantages of targeting drugs to the reticuloendothelial system and enhancing drug efficacy. When liposome, resimod and immunogen are used together, it can improve the adaptive immune response caused by resimod, and when liposome and resimod cooperate, it can stimulate the innate immune response and can synergize, Improve the body's immune response.

Description

technical field [0001] The invention relates to the field of biomedicine, more specifically, to a vaccine adjuvant and a preparation method thereof. Background technique [0002] The purpose of immunization is to induce the body to produce a strong immune response to the vaccination antigen, so as to protect the body from the invasion of corresponding pathogens. For this purpose, inactivated vaccines require the assistance of an adjuvant in contrast to attenuated vaccines. Adjuvant, also known as vaccine modulator or vaccine enhancer, is an additive to a vaccine. When it is injected into the body before or mixed with the antigen, it can enhance the body’s immune response to the antigen or change the type of immune response. Enhancer of non-specific immunity, which itself has no antigenicity. [0003] The Chinese patent with publication number CN101428145A discloses a nanoparticle adjuvant. The composition of the adjuvant contains mineral oil, a surfactant, and an immune en...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/39A61K9/107A61K39/29A61P31/20A61P1/16
CPCA61K9/1075A61K39/12A61K39/39A61K2039/53A61K2039/55511A61K2039/55555A61K2039/55577A61K2039/575C12N2730/10134
Inventor 舒建洪何玉龙陈健王泽宇
Owner 浙江洪晟生物科技股份有限公司
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