The invention provides an implanted flexible neural
microelectrode comb, and a preparation method and an implanting method thereof. The flexible neural
microelectrode comb is mainly composed of a flexible substrate layer, a flexible
insulation layer and a
metal connection wire layer arranged between the flexible substrate layer and the flexible
insulation layer; the flexible neural
microelectrode comb comprises a comb-like structure, a grid structure, a
solid structure and a
welding pad connected in sequence;
electrode sites are arranged on the comb-like structure;
welding points are arranged on the
welding pad; the
metal connection wire layer is composed of
metal connection wires connecting the
electrode sites and the welding points; and the flexible
insulation layer is arranged on the surfaces of the
electrode sites and the welding points. The flexible neural microelectrode comb prepared according to the method provided by the invention has a wire-grid-plane gradual changing structure, and thus is improved in
mechanical stability during a shape changing process. The
mechanical property of the implanted flexible neural microelectrode comb is matched with a
brain tissue, the implanting areas is small, an
inflammatory response of the brain is avoided, and electroencephalogram signals can be stably tracked and measured in a multi-point manner for a long time.