Three-dimensional flexible nervus and preparation method

Abstract

The invention discloses a three-dimensional flexible neural microelectrode and a manufacturing method thereof. The microelectrode uses a flexible polymer as a base material, and performs progressive electroplating through a circular pattern design of a metal seed layer to form smooth three-dimensional convex features. The electrode site structure can not only ensure good contact between the electrode site and the nerve cells, but also avoid damage to the nerve tissue caused by the sharp edges and corners of the raised electrode sites in the existing three-dimensional neural microelectrode. In addition, through the composite electroplating process in the electroplating process, that is, nano-scale dispersants are added to the electroplating solution to form a submicron-scale microporous structure on the surface of the electrode, increasing the surface area of ​​the electrode site, thereby enhancing the current output capability of the electrode and ensuring the nerve. Effective stimulation of microelectrodes under the constraints of biosafety conditions. The three-dimensional flexible neural microelectrode provided by the invention can be widely used in the fields of neurological disease treatment, neurological rehabilitation, neurobiological basic research and the like.

Description

technical field [0001] The invention relates to a three-dimensional flexible neural microelectrode and a manufacturing method, which can be applied to the fields of neurological disease treatment, neurobiological basic research and the like. Background technique [0002] Neural engineering system is currently a very active and rapidly developing research field, such as brain-computer interface, neural prosthesis and other issues have received more and more attention. In the neural engineering system, the most critical component is the nerve-electronic interface, that is, the electrode. Its function is mainly manifested in two forms: one is to convert neural activity into electrical signals and record them for analysis and research; the other is to use Electrical signals excite or inhibit neural activity to achieve functional electrical stimulation (FES). Establishing an efficient and harmonious interface between neural tissue and probing instruments is an extremely challeng...

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Problems solved by technology

However, in this method, the growth of carbon nanotubes on the electrode surface needs to be completed at a high temperature of 700°C-800°C, which is not suitable for the production of polymer flexible electrodes.

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