44 results about "Monolaurin" patented technology

Disclosed is a topical anhydrous, homogenous pharmaceutical composition for treating skin disorder and wounds comprising cod liver oil, hempseed oil, monolaurin, medium chain triglycerides (“MCT”), free fatty acids, sea salt, and vegetable oil selected from the group consisting of red palm concentrate, coconut oil, and red palm oil and combination thereof and optionally fish collagen, ascorbyl palmitate, thickening agent, such as beeswax, red palm concentrate and cetyl ester.

Disclosed is a topical anhydrous, homogenous pharmaceutical composition for treating skin disorder and wounds comprising cod liver oil, hempseed oil, monolaurin, medium chain triglycerides (“MCT”), free fatty acids, sea salt, and vegetable oil selected from the group consisting of red palm concentrate, coconut oil, and red palm oil and combination thereof and optionally fish collagen, ascorbyl palmitate, thickening agent, such as beeswax, red palm concentrate and cetyl ester.

The invention provides refractory concrete and a preparation method thereof, and belongs to the technical field of concrete. The preparation method comprises the following steps: modifying basalt fiber, modifying granite stone powder, grafting and mixing. The step of modifying the granite stone powder comprises the following steps: putting the granite stone powder into an ethanol solution, adding sorbitol laurate and polyoxyethylene sorbitan monolaurate, stirring at the stirring temperature of 46-50 DEG C, uniformly stirring, adding threonine, carrying out ball milling treatment for 26-30 minutes at the ball milling rotating speed of 114-125rpm according to the ball-to-material ratio of (3-5): 1, and after the ball milling is finished, cooling to room temperature to obtain the modified granite stone powder. Filtering and drying to obtain modified granite stone powder; the particle size of the granite stone powder is 135 to 145 nm; the mass concentration of the ethanol solution is 45-50%; the mass ratio of the granite stone powder to the ethanol solution to the sorbitol laurate to the polyoxyethylene sorbitan monolaurate to the threonine is (8.3 to 8.7) to (90 to 97) to (1.0 to 1.2) to (1.1 to 1.5) to (4.5 to 4.9); the prepared refractory concrete is high in strength, excellent in water permeability resistance, good in high-temperature corrosion resistance and low in linear shrinkage rate.

The invention discloses double gel loaded with active substances as well as a preparation method and application of the double gel, and belongs to the technical field of medical dressings. The double gel is composed of a water phase and an oil phase, the water phase comprises oxidized sodium alginate and carboxymethyl chitosan, and the oil phase comprises glycerol monolaurate and camellia oil. Through the synergistic effect of a water phase and an oil phase, a stable double-gel system is formed, hydrophilic epigallocatechin gallate and lipophilic curcumin are loaded, and primary encapsulation of active substances is achieved. According to the double gel loaded with the active substance and the preparation method and application thereof, the double gel has excellent mechanical stability and gel performance, can achieve efficient delivery of the active substance, and has good biocompatibility and application prospects; effective treatment is expected to be achieved in acute burn and scald wound repair, theoretical basis and technical support are provided for application of the double gel in the fields of wound repair and medical cosmetology, and the double gel has the potential of replacing a traditional dressing and becoming a new generation of functional medical dressing.

The invention relates to the technical field of detergents, and discloses a detergent with high foam amount and foam stability. The detergent is prepared from polyoxyethylene sorbitan monolaurate and a surface active agent, in the detergent, the mass fraction of the polyoxyethylene sorbitan monolaurate is 0.02 to 6 percent, and the mass ratio of the polyoxyethylene sorbitan monolaurate to the surfactant is (0.015 to 0.2): 1. According to the invention, the polyoxyethylene sorbitan monolaurate is added into the detergent, the interaction between the polyoxyethylene sorbitan monolaurate and the surfactant can be utilized to reduce the viscosity of the system, so that the detergent is easy to extrude or spray out in a foam form, and the stability of the foam can be improved, so that the detergent can form rich and lasting foam.

The invention discloses a nicotine buccal product for promoting transdermal absorption, and relates to the technical field of nicotine buccal products. The buccal nicotine product for promoting transdermal absorption contains a transdermal absorption enhancer, and the transdermal absorption enhancer is selected from at least one of peppermint oil, wintergreen oil, menthol, azone and derivatives thereof, and sucrose monolaurate. According to the invention, the transdermal absorption enhancer is added into the buccal product, and the lipid fluidity is increased by interfering a cuticle phospholipid bilayer structure, so that the partition coefficient of nicotine in oral mucosa is changed, and the purposes of increasing the nicotine permeation rate and enhancing the nicotine uptake experience are achieved.

The present disclosure pertains to an anhydrous topical composition for retarding and / or inhibiting scarring of a wound, burn and / or skin condition located on the skin of a subject. Additionally, the topical composition may comprise the following: MCT, monolaurin, cetyl esters, marine oil, vegetable oil having an omega 3 fatty acid content greater than 9 wt %, and / or rice bran wax.

Pharmaceutical aerosol formulations containing pre-micronized albuterol sulfate, high amount of green propellant trans-1,3,3,3-tetrafluoropropene (HFO-1234ze(E)), and a surfactant (polysorbate 80 (polyoxyethylene (20) sorbitan monooleate), polysorbate 20 (polyoxyethylene (20) sorbitan monolaurate), polyethylene glycol 1000, span 85 (sorbitan trioleate), polyvinylpyrrolidone K25, or their combination) in a pressurized metered dose inhaler are described. The formulations do not use any co-solvent, i.e., they are co-solvent-free (e.g., free of ethanol, glycerol, propylene glycol, and a combination thereof). The formulations provide highly efficient delivery, through metered dose inhaler (MDI), of pre-micronized albuterol particles into the patients' respiratory tracts and have the advantages of high efficacy, improved safety, and a low global warming potential (GWP) for environmental impact.

The application relates to the technical field of cosmetics, in particular to a water-in-oil system makeup primer and a preparation method thereof. The water-in-oil system makeup primer comprises the following components in parts by weight: cosmetic-grade purified water, cetyl PEG / PPG-10 / 1 dimethicone, dimethicone, isononyl isononanoate, synthetic wax, microcrystalline wax, glycerol, 1,3-propanediol / octyldodecanol / ethylhexylglycerin, butylene glycol, sodium chloride and a polyoxyethylene (20) sorbitan monolaurate-polyoxypropylene (4) sorbitan monolaurate compound. The water-in-oil system makeup primer provided by the application can realize 80% high-aqueous-phase stable bearing, provide sufficient moisturizing reserves for dry skin, realize instant film forming and water locking during smearing, improve the water retention rate to more than 85%, solve the problem of water supplement efficacy attenuation, thereby realize the dual effects of instant water locking and long-acting moisturizing, and resolve the contradiction between water locking and skin feeling.

The present invention discloses a novel stable, single phase aqueous suspension for nasal administration to treat bacterial sinusitis. The composition takes azithromycin dihydrate as an active ingredient, and adopts a suspending agent system to prevent phase separation during storage. Embodiments include a formulation comprising a sorbitan monolaurate, or a combination of chitosan and a sorbitan monolaurate, to maintain the stability of the suspension. The present invention has a variety of advantages, including local delivery of azithromycin to an infected site, which can reduce systemic exposure and associated side effects compared to oral formulations.

A food grade lubricant composition includes an emulsion having 85%-95% w / w water, 1%-4% w / w polyalphaolefin 4, 1%-4% w / w sorbitan monolaurate, 2%-5% w / w polyoxyethylene 20 sorbitan monolaurate, and a food grade preservative.

This invention belongs to the field of pharmaceutical chemistry technology, specifically relating to a monopravir-caprolactam cocrystal, its preparation method, and its applications. The monopravir-caprolactam cocrystal is composed of monopravir and caprolactam in a molar ratio of 1:1.9-2.1. X-ray powder diffraction was performed using Cu-Kα radiation, with angles expressed as 2θ±1, at 6.91, 7.09, 8.38, 11.24, 12.52, 13.26, 13.87, 14.24, 15.22, 16.82, 17.31, and 1... Characteristic peaks are observed at 9.73, 20.22, 20.53, 20.84, 21.90, 22.28, 22.52, 22.95, 23.51, 23.75, 24.00, 24.31, 24.86, 25.35, 26.44, 27.41, 28.02, 28.69, 29.22, 29.84, and 30.33. Monopravir-caprolactam cocrystals can be successfully prepared by grinding and / or solution methods, and grinding and / or melting methods. The preparation process is simple, and the obtained product has high purity. Characterization has confirmed it to be a new cocrystal. Powder flowability and tableting tests revealed that the monopravir-caprolactam cocrystals provided by this invention have better flowability and tableting properties compared to monopravir crystal form I, meeting the requirements of formulation and manufacturing processes.

This invention relates to ophthalmic compositions comprising troxerutin and a surfactant selected from polyoxyethylene 35 castor oil, polyoxyethylene 40 hydrogenated castor oil, polyoxyethylene (20) sorbitan monooleate, polyoxyethylene (20) sorbitan monolaurate, and mixtures thereof, wherein the weight ratio of troxerutin to the surfactant is from 0.02:1 to 100:1, wherein the surfactant is present in an amount of up to 7% by weight relative to the total weight of the composition, and wherein the composition is in the form of a solution, suspension, or gel. The invention also relates to the compositions for treating dry eye disease.

The invention provides a bentonite cat litter deodorizing and dust-reducing agent as well as a preparation method and application thereof. The bentonite cat litter deodorizing and dust-reducing agent comprises an oleic acid emulsion and / or a linoleic acid emulsion, the oleic acid emulsion comprises a mixed emulsifier, an oil phase and water, and the mixed emulsifier comprises polyoxyethylene sorbitan monolaurate and potassium oleate; the oil phase comprises oleic acid and undecanol; the linoleic acid emulsion comprises a mixed emulsifier and an oil phase, and the mixed emulsifier comprises polyoxyethylene sorbitan monooleate and potassium oleate; the oil phase comprises linoleic acid and undecanol. The bentonite cat litter deodorizing and dust-reducing agent has the advantages of fast water absorption, large water absorption and the like of the bentonite cat litter, and successfully overcomes the defects of poor deodorizing capability and large dust of the bentonite cat litter, so that the performance of the bentonite cat litter product is more perfect, and the bentonite cat litter deodorizing and dust-reducing agent has an extremely good application prospect.

The present invention is a novel approach to treating, and even preventing, upper respiratory infections its related symptoms caused by influenza or other lipid-enveloped viruses infiltration and infection in vivo, comprising administering as a gargling agent one or more of clove (plant parts or oil), black tea (with or without caffeine), at least one fatty acid and / or its mono- or di-glyceride form, such as without limitation, coconut water (milk, cream, oil, etc.), caprylic acid, lauric acid (and glycerol monolaurate), monolaurin, myristic acid, oleic acid, palmitoleic acid, or stearic acid, citron, lemon, lime, plant acids (citric acid, etc.), food grade acids (acetic, lactic, malic, oxalic, benzoic, quinic, tannic, and others and / or their sodium salts), vinegar (apple cider, white, balsamic, red wine, wine, etc.), garlic, gangmei root, Sambucus nigra (elderberry), Pelargonium sidoides and or any extract thereof (African geranium), cranberry or pomegranate juice, zinc, saponified lipid (soap), non-toxic detergent, or vitamin C.

The embodiment of the invention discloses a composite freeze-drying protective agent based on CRISPR-Cas13a, a microsphere molecular diagnostic reagent and a preparation method. The composite freeze-drying protective agent comprises a vitrification matrix component, a structure support component, a protein aggregation inhibitor and a surfactant, the vitrification matrix component comprises mannitol and trehalose, and the mass ratio of mannitol to trehalose is (3-7): (3-7); the structural support component comprises any one of PEG8000, PEG6000 and PEG4000 and any one of glucan 10000, glucan 8000 and glucan 20000, and the mass ratio of the PEG8000 to the PEG6000 to the glucan 8000 to the glucan 20000 is (1-5): (1-5); the protein aggregation inhibitor is bovine serum albumin, and the surfactant is polyoxyethylene sorbitan monolaurate; the mass ratio of the structure supporting component to the vitrification matrix component is (1-5): (3-7), the mass ratio of the protein inhibitor to the structure supporting component is (0.01-1): (2-10), and the mass ratio of the surfactant to the structure supporting component is (0.001-0.1): (2-10).

The application discloses a method for continuously synthesizing monolara. Cytidine and acylation reagent are dissolved in a reaction solvent, and acylation is selectively carried out on the fifth site of the cytidine in a micro-channel reactor to obtain 5'-O-methyl propenyl cytosine nucleoside; through extraction and pH adjustment, the solvent is replaced by water to obtain 5'-O-methyl isopropyl cytosine nucleoside aqueous solution; the obtained aqueous solution is pumped into a fixed bed reactor, hydrolysis is completed, and then a hydroxylamine reagent is pumped in; after uniform mixing, the mixture is pumped into a micro-channel reactor to complete hydroxylamine reaction, and monolara aqueous solution is obtained; finally, monolara product is obtained through concentration, cooling, filtration, washing and drying. The application successfully realizes two-step continuous process for preparing monolara, and greatly shortens the time required for synthesizing monolara compared with a kettle type reaction.

The present application relates to a kind of waterproof antifouling wrinkle-resistant high twist cashmere wool yarn, and the high twist yarn of cashmere fiber and wool fiber blend is treated to obtain by composite finishing liquid;The composite finishing liquid includes wool peptide grafting polysiloxane copolymer, multiple anchor, arabic gum grafting epichlorohydrin, wool keratin hydrolysate, polyoxyethylene sorbitan monolaurate, polyglyceryl-3 diisostearate and deionized water.The composite finishing liquid of the present application uses wool peptide grafting polysiloxane copolymer as waterproof antifouling agent, and is homologous compatible with cashmere wool fiber, avoids the hand feeling rigid caused by traditional fluorine reagent;Collaborate arabic gum grafting epichlorohydrin wrinkle-resistant enhancer, and synergistically strengthen wrinkle-resistant performance with high twist structure, simultaneously realize the firm adhesion of functional layer by multiple anchor, give consideration to waterproof antifouling and wrinkle-resistant effect, solve the problem of traditional fluorine waterproof agent hand feeling rigid, function easy to fall off, wrinkle resistance decreases.

The invention discloses a natural, green and easy-to-wash food detergent, and relates to the technical field of detergents, and the technical scheme is as follows: the natural, green and easy-to-wash food detergent is prepared from the following raw materials in parts by weight: 10-15 parts of sodium fatty alcohol polyoxyethylene ether sulfate; the invention relates to a washing agent, which is prepared from the following raw materials in parts by weight: 1 to 3 parts of fatty alcohol-polyoxyethylene ether, 1 to 4 parts of fatty acyl diethanol amine, 1 to 3 parts of cocamidopropyl ammonium oxide, 2 to 5 parts of C8-16 alkyl glucoside, 1 to 3 parts of polyoxyethylene (20) sorbitan monolaurate, 0.1 to 0.5 part of tetrasodium glutamate diacetate and 65 to 75 parts of deionized water. The environment-friendly tableware detergent is rich in foam, capable of effectively cleaning greasy dirt, vegetables and fruits, antimicrobial and environmentally friendly, the raw materials are cheap, the product is safe and renewable, and the raw materials are natural plant source surfactants, so that the environment-friendly tableware detergent is low in cost, convenient to transport, environmentally friendly, free of irritant components, natural and harmless.

The invention includes a method for treating a vascular abnormality of the skin of a human subject, comprising topically administering to the abnormality a composition comprising: a) Rapamycin; b) Monolaurin and Monomyristin as vehicle; and c) water; once daily at a rate of: d) 4 -8 mg Rapamycin / cm2; and / or e) 1-6 mg Rapamycin.

The invention provides a refractory concrete and a preparation method thereof, belonging to the technical field of concrete; the preparation method comprises modified basalt fiber, modified granite powder, grafting and mixing steps; the step of modifying the granite powder comprises placing the granite powder in an ethanol solution, adding sorbitol dodecanoate and polyoxyethylene sorbitan monolaurate for stirring at a stirring temperature of 46-50 DEG C, adding threonine after stirring evenly, and performing ball milling treatment at a ball milling time of 26-30 min, a ball milling speed of 114-125 rpm, and a ball-to-material ratio of 3- 5:1, after the ball milling is completed, the modified granite powder is obtained by filtering and drying; the particle size of the granite powder is 135-145nm; the mass concentration of the ethanol solution is 45-50%; the mass ratio of the granite powder, ethanol solution, sorbitol dodecanoate, polyoxyethylene sorbitan monolaurate, and threonine is 8.3-8.7:90-97:1.0-1.2:1.1-1.5:4.5-4.9; the refractory concrete prepared by the present invention has high strength, excellent water permeability resistance, good high temperature corrosion resistance, and low linear shrinkage.

An example of the present invention provides a fuel additive composition, which includes a mixture of a mixture of tert-butylhydroquinone, a catalyst, a lubricant, a lubricant, a lubricant, a lubricant, a lubricant, a lubricant, a lubricant, a lubricant, a lubricant, and a lubricant. The CAS number is 1948-33-0), and the CAS number is 1948-33-0), and the CAS number is 1948-33-0), and the CAS number is 1948-33-0, and the CAS number is 1948-33-0; the invention relates to a calcium acetylacetonate hydrate and a preparation method thereof. The calcium acetylacetonate hydrate is characterized in that the CAS number is 61789-86-4. The invention relates to a high-base-number petroleum calcium sulfonate, which is characterized in that the CAS number is 345909-31-1), and the high-base-number petroleum calcium sulfonate is prepared by the following steps of: preparing a high-base-number petroleum calcium sulfonate, a high-base-number petroleum calcium sulfonate and a high-base-number petroleum calcium sulfonate; the CAS number is 68783-96-0), and the content of sorbitan monolaurate (Sorbitan monolaurate; the CAS serial number is 1338-39-2) and 2-ethylhexyl nitrate ester (2-ethylhexyl nitrate; the CAS serial number is 1338-39-2) and 2-ethylhexyl nitrate ester (2-ethylhexyl nitrate; and the CAS serial number is 27247-96-7). The fuel additive composition according to one embodiment of the present invention can be added to various fuels such as gasoline, light oil, heavy oil and the like to improve the combustion efficiency at the time of fuel combustion while significantly reducing the generation of atmospheric pollutants such as particulate matter (PM), carbon monoxide (CO), hydrocarbon (HC), nitrogen oxide (NOx) and the like.

The present invention provides a composition that suppresses the chemical decomposition of rapamycin during storage. [Solution] A local therapeutic composition, a) Rapamycin as the active ingredient; b) Vehicles including the following: ○Monolaurin, for example, as glyceryl monolaurate; and ○Monomyristate, for example, as glyceryl monomyristate; and c) Water as a solvent A composition containing the following:

To propose a method for effectively reducing the amount of fluorine-containing emulsifiers that may remain in aqueous emulsion polymerization solutions of fluoropolymers, including fluoroelastomers and perfluoroelastomers. [Solution] The following steps: A process of passing a weakly acidic aqueous solution through a hydroxide ion type strongly basic anion exchange resin. A step of adding polyoxyethylene (20) sorbitan monolaurate to an aqueous dispersion of fluoropolymer containing a fluorine-containing emulsifier, followed by A step to obtain an aqueous fluoropolymer dispersion by passing a fluoropolymer aqueous dispersion containing polyoxyethylene (20) sorbitan monolaurate and a fluorine-containing emulsifier through a strongly basic anion exchange resin through which the weakly acidic aqueous solution has been passed. A method for producing an aqueous dispersion of a fluoropolymer containing at least [a specific substance] is provided. Furthermore, a method for producing a fluoropolymer is provided for obtaining a fluoropolymer from the obtained aqueous dispersion of a fluoropolymer.

This invention relates to a wall painting coating and its preparation method, belonging to the field of polymer coating technology. The wall painting coating of this invention comprises the following components in parts by weight: 35-45 parts of waterborne acrylic copolymer emulsion; 15-25 parts of waterborne iron oxide red paste; 1.8-2.5 parts of silane-modified attapulgite clay; 0.4-0.6 parts of associative polyurethane thickener; 0.6-1.0 parts of wood fiber; 0.8-1.2 parts of wetting and dispersing agent; 0.15-0.2 parts of defoamer; 2.0-3.0 parts of film-forming aid; and 31-33 parts of water. The wetting and dispersing agent is sorbitan monolaurate, N,N-bis(2-hydroxypropyl)-dodecanoamide, or N-tris(hydroxymethyl)methyl-citrate monohydrazide amide.

The embodiment of the application provides a quick-drying floor sterilization cleaner, which is composed of the following components in parts by weight: 15-30 parts of a surfactant; 2-4 parts of a bactericide, the bactericide being polyhexamethylene biguanide hydrochloride; 1.5-4 parts of a quick-drying agent, the quick-drying agent being composed of polyether modified silicone oil and polyoxyethylene sorbitan monolaurate; 0-1 part of a pH regulator, the pH value being 6-8; 0.1 part of essence; 5-10 parts of a solvent; and deionized water to make up to 100 parts. The surfactant, the bactericide and the quick-drying agent compounded together in the application have a synergistic effect, so that the sterilization effect and the quick-drying effect are realized at the same time.

Described herein relates to a topical anhydrous, homogenous pharmaceutical composition for treating skin disorder and wounds comprising cod liver oil, hempseed oil, monolaurin, medium chain triglycerides (“MCT”), free fatty acids, sea salt, and vegetable oil selected from the group consisting of red palm concentrate, coconut oil, and red palm oil and combination thereof and optionally fish collagen, ascorbyl palmitate, thickening agent, such as beeswax, red palm concentrate and cetyl ester.

Provided is an emulsifier composition containing: (A) a polyoxyalkylene alkyl ether represented by formula (1); (B) one or more sorbitan mono-fatty acid esters selected from the group consisting of sorbitan monolaurate, sorbitan monomyristate, sorbitan monopalmitate, sorbitan monostearate, and sorbitan monooleate; and (C) one or more polyhydric alcohols selected from the group consisting of 1,2-alkanediols having 6-18 carbon atoms and monoalkyl glyceryl ethers having a hydrocarbon group having 6-8 carbon atoms. In formula (1), R1 represents an alkyl group having 10-18 carbon atoms, and the average values of n and m independently represent a number of 0-10. Provided that, at least one of n and m is not 0.

The invention discloses an emulsifier, a preparation method and an application method, the emulsifier has the advantages of low cost, environmental protection, food safety and easiness in use, and the problems of high consumption, high cost and potential food safety of traditional milk in coffee art practice are solved. The emulsifier is prepared by mixing polyoxyethylene (20) sorbitan monolaurate and polyethylene glycol 400 monooleate according to a specific mass ratio, and can simulate the physical characteristics, including density, stability and milk foam quality, of the whipped milk at normal temperature. Through an accurate formula and a simple preparation process, the emulsifier disclosed by the invention can provide experience similar to that of real milk in the coffee art, meanwhile, the dependence on milk is reduced, the food waste is reduced, and the practice efficiency of coffee professionals is improved. Besides, the main component of the emulsifier is a food additive, so that the emulsifier is safer to use and does not threaten human health, and the environmental problem possibly caused by using chemical raw materials is also avoided.

A reactive calcium oxide (CaO) catalyst for catalytic applications is disclosed. The catalyst comprises calcium oxide particles exhibiting rod-like and dumbbell-shaped morphologies and particle characteristics associated with enhanced catalytic activity in monolaurin synthesis. The catalyst possesses reduced particle agglomeration and increased accessible surface area relative to calcium oxide materials produced under non-optimized calcination conditions. In certain embodiments, the catalyst exhibits an average particle size in the nanometer range suitable for glycerolysis reactions. The reactive calcium oxide catalyst may be derived from thermal decomposition of calcium hydroxide precursor material and is suitable for use in monolaurin production and related catalytic processes.