The invention provides a liquid phase hydrofining method of 1, 5-pentanediol. According to the method, a two-step process is adopted, firstly, dimethyl glutarate is generated through an esterificationreaction, and secondly, 1, 5-pentanediol is generated through a dimethyl glutarate liquid-phase hydrogenation process by adopting a modified nickel-based supported catalyst. According to the liquid phase hydrofining method, reaction is carried out on a fixed bed hydrogenation device, the adopted catalyst is a modified nickel supported catalyst, hydrogen required by reaction is providedby a liquidcirculating material, no expensive hydrogen circulating compressor is needed to be arranged in the device, a material passing through a reactor is a single liquid phase material, the production costis reduced, and the product quality is improved.