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Quercetin nanostructured lipid carrier and preparation method thereof

A nanostructured lipid and quercetin technology, applied in the field of carrier systems, can solve the problems of easy degradation of quercetin, achieve the effects of no organic solvent residue, simple preparation method, and improved efficacy

Inactive Publication Date: 2014-12-03
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Technical problem: The purpose of the present invention is to provide a quercetin nanostructured lipid carrier with high physical and chemical stability, no organic solvent residue, and good biocompatibility and its preparation method to solve the problem of quercetin's easy degradation and water solubility when exposed to light and heat. Improve the bioavailability of quercetin

Method used

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  • Quercetin nanostructured lipid carrier and preparation method thereof
  • Quercetin nanostructured lipid carrier and preparation method thereof
  • Quercetin nanostructured lipid carrier and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Preparation of Quercetin Nanostructured Lipid Carrier

[0033] Composition formula

[0034]

[0035] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0036] 1. Accurately weigh 2.4 grams of glyceryl monostearate, 3.6 grams of acetylated monoglyceride, 4.0 grams of glyceryl caprylate, 3.84 grams of polyoxyethylene sorbitan monolaurate and 200 mg of quercetin. Put the lipid material and emulsifier into a beaker, heat the lipid material and emulsifier in a water bath at 70°C and stir evenly to obtain a liquid oil phase containing part of the emulsifier.

[0037] 2. Accurately weigh 2.56 g of hexaglycerol monostearate, 1.6 g of sucrose ester, and 81.8 g of deionized water into a beaker, heat in a water bath at 70°C, and stir evenly to obtain a water phase.

[0038] 3. Slowly add the obtained oil phase containing emulsifier into the water phase, stir and mix evenly, and at the same time, high-shear for 1 min to obtain colostr...

Embodiment 2

[0041] Example 2 Preparation of Quercetin Nanostructured Lipid Carrier

[0042] Composition formula

[0043]

[0044]

[0045] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0046] 1. Weigh 2.4 grams of stearate, 3.6 grams of acetylated monoglycerides, 4.0 grams of caprylic capric acid glycerides, 2.4 grams of decaglycerol monolaurate and 100 mg of quercetin into a beaker, and carry out a water bath at 70 °C Heat, and stir well.

[0047] 2. Weigh 1.6 g of hexaglyceryl monostearate, 1.0 g of sucrose ester, and 84.9 g of deionized water into a beaker, heat in a water bath at 65°C, and stir evenly to obtain a water phase.

[0048] 3. Slowly add the obtained oil phase containing emulsifier into the water phase, stir and mix evenly, and at the same time, high-shear for 1 min to obtain colostrum.

[0049] 4. Inject the colostrum into a high-pressure homogenizer preheated at the same temperature for homogenization, adjust the homogenizati...

Embodiment 3

[0051] Example 3 Preparation of Quercetin Nanostructured Lipid Carrier

[0052] Composition formula

[0053]

[0054] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0055] 1. Weigh 2.4 grams of glyceryl monostearate, 3.6 grams of monolaurate, 4.0 grams of soybean oil, 2.4 grams of polyoxyethylene sorbitan monolaurate and 200 mg of quercetin into a beaker for 60 ℃ water bath, and stir well.

[0056] 2. Weigh 1.6 g of hexaglycerol monostearate, 1.0 g of soybean powder phospholipid, and 84.8 g of deionized water into a beaker, heat in a water bath at 60°C, and stir evenly to obtain a water phase.

[0057] 3. Slowly add the obtained oil phase containing emulsifier into the water phase, stir and mix evenly, and at the same time, high-shear for 2 minutes to obtain colostrum.

[0058] 4. Inject the colostrum into a high-pressure homogenizer preheated at the same temperature for homogenization, adjust the homogenization pressure to 80MPa, and p...

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Abstract

The invention discloses a quercetin nanostructured lipid carrier and a preparation method thereof, wherein the quercetin nanostructured lipid carrier comprises the following components by weight percent: 0.1-1% of quercetin, 2%-15% of an emulsifying agent, 2%-15% of compound lipid material and the balance being water. The compound lipid material is a solid-liquid state lipid mixture; the solid lipid is one or more of acetylation monoglyceride, stearate, glyceryl monostearate and monolaurate; the liquid lipid is one or more of decanoyl / octanoyl-glycerides, camellia oleosa seed oil, soybean oil and peanut oil. The quercetin is loaded by utilizing a nanostructured lipid carrier technique, on the one hand, the sensibility of the quercetin to the environmental factors such as illumination and temperature can be reduced, and the chemical stability is improved, and on the other hand, the solubility of the quercetin in water can be improved, thereby improving the bioavailability. The preparation method is simple and controllable, and is good in reproducibility; the quercetin nanostructured lipid carrier emulsion prepared by the method is suitable for being added into functional food beverages.

Description

technical field [0001] The invention relates to a nano-scale carrier and a preparation method thereof, in particular to a nano-structured lipid carrier with quercetin as an active ingredient and a preparation method thereof, belonging to the technical field of carrier systems in functional food preparation technology. Background technique [0002] With the improvement of human living standards, various related diseases follow, and human beings pay more and more attention to their own health. Humans' requirements for diet are not only to meet their own physiological needs, but also to pay more attention to the relationship between diet and their physical and mental health. Therefore, functional foods added with various bioactive ingredients are more and more favored by humans. [0003] Quercetin is a polyhydroxyflavonoid compound, chemically named 3,3',4',5,7-pentahydroxyflavone, which has a variety of biological activities and high medicinal value. Quercetin widely exists i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/30
CPCA23L2/52A23L33/10A23V2002/00A23V2250/21168A23V2200/222
Inventor 夏强倪石磊
Owner SOUTHEAST UNIV
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