The invention discloses a method of preparing a plurality of activation materials from
ginkgo leaves, and belongs to a manufacturing method of chemical substances or a manufacturing method of drugs. Strong polarity macroporous adsorption resin or polarity macroporous adsorption resin is adopted for separation, and is adopted to solve the problems that the amount of
ginkgolic acid is high when the prior
ginkgo extract is prepared, and solve the problems that a large amount of
organic solvent is consumed when the prior
ginkgo active substances are extracted and prepared, and accordingly the environment is polluted, or that a complex
separation technology can not enlarge production, or that extraction efficiency is not high, and use ratio of raw materials is low and the like. The method of preparing the plurality of activation materials from the ginkgo leaves can simultaneously obtain a plurality of active substances such as ginkgo
polysaccharide, ginkgol biloba extracts, ginkgol biloba general flavone, ginkgol biloba total lactones, gbilobalide A monosome, gbilobalide B monosome, gbilobalide C monosome and the like. The technical scheme is that the method comprises a
raw material pretreatment step, an extraction step, a
polysaccharide precipitation step, a
macroporous resin separation step, a
silica gel dry-column separation step, a
reversed phase chromatography purification step, a
crystallization step and the like, saves production cost, and improves work efficiency. The process of the method is simple and convenient to conduct. The method can be easily enlarged to the commercial process, and meanwhile greatly increase use ratio of raw materials.