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Percutaneous dosing paster based on microneedle array flexible chip and preparation method thereof

A microneedle array and flexible technology, applied in the direction of microneedles, needles, medical devices, etc., can solve the problems of not being comfortable and convenient to use, and the microneedle array chip is not easy to fit the skin, so as to improve the efficacy of medicine or beauty. effect, improved percutaneous penetration, highly reproducible effect

Inactive Publication Date: 2010-01-06
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the microneedle array chip using a metal substrate is not easy to fit the shape of the skin, and it is not comfortable and convenient to use.

Method used

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  • Percutaneous dosing paster based on microneedle array flexible chip and preparation method thereof
  • Percutaneous dosing paster based on microneedle array flexible chip and preparation method thereof
  • Percutaneous dosing paster based on microneedle array flexible chip and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Figure 1-Figure 12 Shows the microneedle array flexible chip provided by the present invention, the microneedle array flexible chip includes a flexible substrate 1 and a number of microneedles 2 arranged on the flexible substrate 1, the number of microneedles 2 according to a certain The spacing forms a microneedle array. The microneedle 2 includes a needle bar 3 and a needle point 4 located at the top of the needle bar 3 . The microneedle 2 is fixed on the flexible substrate 1 through the lower part of the needle bar 3 . The flexible substrate 1 may include an upper substrate 5 and a lower substrate 6 stacked together, and the lower part of the microneedle 2 at least penetrates the upper substrate 5 . The microneedles 2 can be arranged perpendicular to the flexible substrate 1, or can be arranged on the flexible substrate 1 obliquely at a certain angle, and the angle is preferably 15°-90°.

[0078] figure 1 and figure 2 It is a schematic structural diagram of a mi...

Embodiment 2

[0117] Manufacturing method of stainless steel microneedle array flexible chip

[0118] Insert a stainless steel needle with an outer diameter of 150 microns in each hole of the through-hole array mold, and after these stainless steel needles vertically penetrate a piece of non-woven fabric 5, cut off these stainless steel needles at a distance of about 1mm from the cloth with a cutting machine . The method of screen printing is used to coat epoxy resin at the fracture of the stainless steel needle and form an array of needle holders 10 after curing. Finally, another piece of non-woven fabric 6 is bonded to the above-mentioned non-woven fabric 5 and needle holders 10 to form a stainless steel microstructure. Needle array flexible chip.

Embodiment 3

[0120] Manufacturing method of stainless steel microneedle array flexible chip

[0121] A stainless steel wire rod with an outer diameter of 150 microns is inserted into each hole of the through-hole array mold, and then these wire rods penetrate the upper substrate (silicone rubber layer) 5 with a thickness of about 1 mm along a certain angle. Use a cutting machine to cut these wire rods, and grind and polish the fracture surface in a direction parallel or inclined to the substrate to form a needle tip 4 with an elliptical plane, such as Figure 13 As shown in A. After freezing at minus 100°C, use the baffle to push the upper part of the needle shaft to further adjust the tilt angle of the microneedle, such as Figure 13 Shown in B. The method of screen printing is used to coat epoxy resin at the fracture of the lower part of the needle bar and form an array of needle holders 10 after curing, such as Figure 13 C shown. Finally, another lower substrate (silicone rubber la...

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Abstract

The invention discloses a microneedle array flexible chip which comprises a flexible substrate and two or more microneedles arranged on the flexible substrate at intervals. Each microneedle comprises a needle rod and a tip arranged at the top end of the needle rod, and the microneedle is fixed on the flexible substrate through the lower part of the needle rod. By organically combining a microneedle array and the flexible substrate, the invention can enable medicine or facial skin care products to pass through horny layers and enter epidermal layers and dermis layers quickly, thereby significantly improving the medicine effect or the effect of facial beautifying and nursing; in addition, the invention takes advantage of a mature process to realize the low-cost high-yield high-repetitiveness production in batch.

Description

technical field [0001] The invention relates to the technical field of medical and cosmetic devices, in particular to a microneedle array flexible chip, a transdermal drug delivery patch based on the chip and a preparation method. Background technique [0002] Human skin has three layers of tissue: stratum corneum, active epidermis and dermis. The thickness of the outermost stratum corneum is about 30-50 microns, and it is composed of dense corneocytes. Its permeability to most drugs is very low, which is the main obstacle to the transdermal delivery of these drugs; below the stratum corneum is the epidermis, The thickness is about 50-100 microns, containing living cells and a small amount of nerve tissue, but no blood vessels; below the epidermis is the dermis, which is the main component of the skin and contains a large number of living cells, nerve tissue and blood vessel tissue. The outer diameter of the needle used in the traditional subcutaneous injection method is ge...

Claims

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Application Information

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IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0053
Inventor 岳瑞峰王燕
Owner TSINGHUA UNIV
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