Cosmetic skin needle, its manufacturing method and use

A technology of epidermal needles and needle bodies, which is applied in applications, household appliances, household packaging, etc., can solve the problems of inconvenient use of injections, and achieve the effect of low price, simple process and good durability

Active Publication Date: 2005-06-08
SUZHOU NASHENG MICROELECTRONICS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Many beauty nutrients, including collagen source protein, sodium hyaluronate, elastin, coenzyme Q10, vitamin sugar ester bioactive agents, botulinum toxin (such as Botox), hyaluronic acid (such as Restylane) and other nutrients, due to The molecular weight is relatively large or the hydrophilicity is relatively strong. When it is made into ointment, water or general patch and used, the content of active ingredients penetrating into the skin is very small, and the function of these nutrients cannot be effectively exerted
Therefore, many beauty nutrients are made into injections for use, but injections are inconvenient to use, require specially trained personnel to operate, and users have pain

Method used

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  • Cosmetic skin needle, its manufacturing method and use
  • Cosmetic skin needle, its manufacturing method and use
  • Cosmetic skin needle, its manufacturing method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1: Production of conical solid monocrystalline silicon cosmetic epidermis needles

[0047] See attached figure 1 And attached figure 2 Shown, single-sided polished silicon type, 500 µm thick as raw material. The single crystal silicon was first cleaned with a cleaning solution containing 5 parts of deionized water, 1 part of 30wt% hydrogen peroxide and 1 part of 30wt% ammonia water at a temperature close to 80°C, and then dried at 150°C for 10 minutes. A silicon dioxide layer with a thickness of about 1.5 microns is grown and formed on the surface of single crystal silicon through high temperature thermal oxidation at 900-1100 ° C; a uniform layer of 1-2 microns is coated on the silicon dioxide film by the spin coating method Thick Shipley1818 photoresist, pre-baked (soft-baked) at 90°C for 5 minutes, and formed a 80×80 array of solid circles with a diameter of 150 microns and a pitch of 200 microns in a unit of 1 square centimeter. (Quartz glass is used i...

Embodiment 2

[0048] Example 2: Production of Polymer Material Cosmetic Epidermis Needle

[0049] Using the monocrystalline silicon cosmetic epidermis needle obtained in Example 1 as a master model, plate a layer of gold film on its surface as a conductive layer, and then utilize electroplating to grow a layer of metal nickel with a thickness of about 1.5 mm on the surface of the monocrystalline silicon epidermal needle. Boiling the above electroformed object in 30%-50% potassium hydroxide solution to remove single crystal silicon to obtain a nickel mold.

[0050] Adopt macromolecule material, use vacuum injection molding method, utilize above-mentioned nickel mold to prepare and obtain the cosmetic epidermis needle of macromolecule material, as attached image 3 shown.

Embodiment 3

[0051] Embodiment 3: Rat in vitro transdermal release curve with bovine serum albumin and botulinum toxin as model nutrients

[0052] Bovine serum albumin and botulinum toxin solutions were used as model nutrients.

[0053] Take one piece of hair-removed rat skin, place the cuticle upwards on the mouth of the diffusion pool, and place the solid epidermis needles prepared in Example 1 (400 needles in an area of ​​4 square millimeters, and the distance between the needles is 200 microns) on it. On the top, gently press the epidermal needle with your hand to make micropores on the skin, but do not penetrate the skin. The stratum corneum of the skin faces the drug supply chamber (the concentration of each substance in the supply chamber is 0.1mM, 1ml), and the dermis faces the drug receiving chamber. , fill the receiving chamber with phosphate buffer (pH 7.4) preheated to 37°C, seal the sampling port with a parafilm, and place it in a constant temperature water bath at 37°C. Unde...

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Abstract

An epidermal needle device for beautifying skin is composed of a sheet-type bearing body and a needle array on said bearing body. Said needles can pass through the horny layer of skin but not in dermis layer, and are prepared from monosilicon material through etching, or from high-molecular material or other materials. With said device, the skin-beautifying nutrients, such as collagen, elastin, coenzyme Q10, etc, can be percutaneously absorbed by skin.

Description

technical field [0001] The invention relates to a device for introducing a medium into the human body through the skin, in particular to a skin needle used for beauty treatment, and also relates to a production method and application of the skin needle. Background technique [0002] It is impossible for anyone to escape the fate of aging. Smoking and ultraviolet radiation will accelerate the skin aging process. With the improvement of people's living standards, skin beauty has attracted more and more attention. Although the internal factors of skin aging are not yet fully understood, it has been proven that the reduction of collagen and the loss of water are important reasons for skin aging. [0003] Collagen elastic fibers can maintain the elasticity and toughness of the skin. When the collagen starts to decrease gradually, the skin becomes thinner, brittle, and prone to chapping. These changes lead to wrinkles, bags under the eyes, double jaws and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A45D44/22A61B17/00A61M37/00
Inventor 徐百高云华林朝
Owner SUZHOU NASHENG MICROELECTRONICS CO LTD
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