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Active energy radiation hardenable skin plaster composition and skin plaster

A technology of active energy and skin patches, applied in the direction of non-polymer organic compound adhesives, active ingredients of heterocyclic compounds, drug combinations, etc., can solve problems such as yellowing, exudation, and working environment problems of cured films

Inactive Publication Date: 2006-10-04
TOAGOSEI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the component is irradiated with an active energy beam, the temperature rises due to the heat of polymerization, so a low-molecular-weight photopolymerization initiator or the like having a high vapor pressure causes a problem that a bad odor is remarkably generated at the time of curing, thereby causing Work environment problems, or contamination of obtained products
In addition, there is a problem that decomposition products including unreacted photopolymerization initiator and the like remain in the cured film, and therefore, when light or heat is applied to the cured film, there is often such a problem that the cured film turns yellow, or unpleasant smell
[0010] In addition, in the case where the composition is applied to a patch, when the cured film is wetted with water, or when the cured film is in contact with sweat excreted from the human body, etc., the unreacted photopolymerization initiator or the like oozes out in a large amount, so safety and health issues

Method used

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  • Active energy radiation hardenable skin plaster composition and skin plaster
  • Active energy radiation hardenable skin plaster composition and skin plaster
  • Active energy radiation hardenable skin plaster composition and skin plaster

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0240] The composition of the present invention must only include the above-mentioned components (A) and (B) as essential components; as component (A) is preferably as follows.

[0241] Specifically, a component that is liquid at normal temperature is preferable as component (A). Furthermore, the above-mentioned component (I) or (II) is preferable as the component (A). Preference is given to components having a polyether backbone and a polyester backbone as component (A); components having a polyether backbone are particularly preferred. In addition, it preferably has a number average molecular weight of 1,000 to 20,000 as the component (A).

[0242] In addition, the composition of the present invention preferably contains a pharmaceutical component.

Embodiment 1 to 13 and comparative example 1 to 7

[0271] Using the maleimide compounds produced in the above production examples and comparative production examples, a composition for skin patches was produced according to the formulation given in Table 2 by the following method: the components were thoroughly mixed until the mixture became uniform, and then defoaming.

[0272] The obtained composition was coated with a thickness of 50 μm on the surface of a polyester film with a thickness of 50 μm as a substrate sheet, and a high-pressure mercury lamp (one lamp; 10 cm High), the sheet was passed 4 times at a transport speed of 10 m / min, and ultraviolet light was irradiated from the coated surface (accumulated amount of light = 1200 mJ / cm 2 ), whereby the composition is cured to produce a patch.

[0273] It should be noted that in Example 10 and Comparative Example 6, the composition was heated to 50°C and then applied, and in Comparative Example 7, C1 was heated to 80°C to melt and then applied.

[0274] In each of Example...

Embodiment 14 to 24

[0311] Examples 14 to 24 (Patch Compositions Containing Drug Components)

[0312] Using the maleimide compound produced in the above Production Example, a composition for a skin patch was produced according to the formulation given in Table 3 by mixing the components well until the mixture became uniform, followed by defoaming.

[0313] The obtained composition is coated with the thickness of the composition layer given in Table 3 on the surface of a polyester film with a thickness of 50 μm as the substrate sheet, and is concentrated under high pressure at 120W / cm with a UV irradiator equipped with a transmission belt. Under a mercury lamp (one lamp; 10 cm high), the sheet is passed repeatedly at a conveying speed of 10 m / min, and ultraviolet light is irradiated from the coated surface until the cumulative amount of light reaches the value given in Table 3 (each pass Accumulated amount of light = 300mJ / cm 2 ), whereby the composition is cured to produce a patch.

[0314]The ...

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Abstract

A composition curable with active energy beams for use in skin patches is provided, which is liquid at ordinary temperature, has a practical crosslinking property or curability in the absence of photopolymerization initiators even when irradiated with visible or ultraviolet light, and provides cured films that are not discolored and excellent in various pressure-sensitive adhesive performances and have appropriate pressure-sensitive adhesiveness so as not to cause pain or damage to the horny layer in the patch-applied area even when patches are repeatedly applied and peeled off, as well as excellent water resistance. [Means for solving problems] The composition curable with active energy beams for use in skin patches is liquid at ordinary temperature and comprises (A) a compound having two or more maleimide groups and (B) an oil component, or water or a water-soluble compound.

Description

technical field [0001] The present invention relates to a composition curable with active energy beams for skin patches, the composition is composed of compounds containing two or more specific maleimide groups, and the present invention also relates to compounds having the above-mentioned combination A skin patch with a pressure-sensitive adhesive layer formed by a substance. They can be advantageously used in related technical fields. Background technique [0002] The patch is used for the purpose of protecting an injured part of the skin surface, having a drug component for treating a disease, which is transdermally absorbed to deliver it to a living body, and other purposes. In particular, they are called first aid plasters, magnetic plasters, surgical tapes, wound healing dressing materials (dressings), sports tapes, tape preparations, plasters, poultices and the like. [0003] The properties required for use in patches are that the patches are excellent in adhesivene...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/30A61K9/70A61L15/00C09J4/00C08G18/83A61K9/00A61L15/07C08G18/67C09J175/16
CPCA61L15/07A61K9/7023C09J175/16C09J4/00C08G18/6735A61K41/0042A61K9/0009A61P29/00A61K9/70A61K31/40
Inventor 伊藤贤司神谷大介
Owner TOAGOSEI CO LTD
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