A kind of preparation method of bioglass/amino acid polymer composite material

Abstract

The invention discloses a preparing method for a bioglass / amino acid polymer composite. The preparing method comprises the following steps that epsilon-aminocaproic acid and other alpha-amino acid are taken and added with water, the mixture is dehydrated at 150-160 DEG C and then heated to 200-220 DEG C to be reacted for 2-3 h under the protection of nitrogen, the mixture is then heated to 230-235 DEG C to be reacted for 1-2 h, and an amino acid polymer is generated; then, bioglass is added, the mixture is evenly mixed and cooled, and the bioglass / amino acid polymer composite is obtained. The composite prepared through the method can have enough mechanical strength in the initial stage, can also be quickly degraded in the later stage and can meet the requirements for the mechanical strength and the degradation property at the same time; in addition, the method is easy and convenient to implement, simple in operation, convenient to control, safe, environmentally friendly, low in energy consumption, short in cycle, high in production efficiency and suitable for industrial application.

Description

technical field [0001] The invention relates to a preparation method of bioglass / amino acid polymer composite material. Background technique [0002] When bone tissue repair materials are applied to the repair of bone defects caused by lesions or trauma in the spine, limbs, and head, on the one hand, it is required to provide sufficient mechanical strength at the initial stage of implantation; In the later stage of tissue healing, it can be rapidly degraded to avoid unpredictable risks caused by changes in material properties. [0003] However, for bone tissue repair materials, maintaining high mechanical strength and rapid degradation are a pair of mutual constraints. For example, the bone repair composite material prepared by the method of Chinese patent CN 101716380 A can be rapidly degraded, but its mechanical strength is very low. The compressive strength is lower than 17 MPa; while the bone repair material prepared by the method of Chinese patent CN 104324415 A can pr...

AI Technical Summary

Problems solved by technology

[0003] However, for bone tissue repair materials, maintaining high mechanical strength and rapid degradation are a pair of mutual constraints. For example, the bone repair composite material prepared by the method of Chinese patent CN 101716380 A can be rapidly degraded, but its mechanical strength is very low. The compressive strength is lower than 17 MPa; while the bone repair material prepared by the method of Chinese patent CN 104324415 A can provide high enough mechanical strength, but it is difficult to degrade; it can be seen that the bone repair material prepared by the existing method is usually difficult to meet the above two requirements at the same time. Requirements in other aspects, resulting in poor effect when applied to bone defect repair