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Aminocaproic acid medicine composition and pharmaceutical application thereof

A technology of aminocaproic acid and composition, which is applied in the field of aminocaproic acid pharmaceutical composition, can solve the problems of covering the wound surface, not being able to immediately determine the size and depth of the wound surface, and increasing the suffering of patients, achieving significant progress and improving the protective effect of deep burns , the effect of highlighting the substantive characteristics

Inactive Publication Date: 2016-07-20
李晨露
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Doctors in the emergency room often find that people mistakenly apply toothpaste, egg white, or even salt, soy sauce, red syrup, etc. to burn wounds, which not only have no effect on treating burns, but sometimes cover the wound, making it impossible for doctors to immediately determine the extent of the wound. The size and depth must be cleaned before rescue. This process is time-consuming and laborious, which will increase the pain of the patient
[0005] So far, there has been no report on the correlation between aminocaproic acid and its pharmaceutical composition and the protection of deep burns

Method used

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  • Aminocaproic acid medicine composition and pharmaceutical application thereof
  • Aminocaproic acid medicine composition and pharmaceutical application thereof
  • Aminocaproic acid medicine composition and pharmaceutical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0019] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0020] Separation method: (a) Grind the dried senna leaves (5kg), extract with 75% ethanol under heat reflux (20L×3 times), combine the extracts, concentrate to no alcohol smell (4L), and then use petroleum ether (4L ×3 times), ethyl acetate (4L×3 times) and water-saturated n-butanol (4L×3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) In the step (a), the n-butanol extract is removed with D101 type macroporous resin, first eluted with 8% ethanol for 6 column volumes, then with 70% ethanol for 8 column volumes, collected 70% eluate, and reduced Co...

Embodiment 2

[0023] Example 2: Protective effect on rat deep second-degree burn model

[0024] 1. Materials and methods

[0025] 1.1 Animals

[0026] SD rats, 100, weighing 180-230 g, ordinary grade, were purchased from Anhui Changlinhe Pharmaceutical Technology Co., Ltd. The animals were kept in a ventilated and dry environment with a temperature of (22±1)°C, a relative humidity of 55%-65%, and a light cycle of 12 hours. Rats and mice were fed with maintenance diet 1022, and they had free access to water and food.

[0027] 1.2 Reagents and samples

[0028] Aminocaproic acid was purchased from China Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Moist burn ointment (Shirun ShaoshangGao, SRSSG), Shantou Meibao Pharmaceutical Co., Ltd., batch number 131201; vascular endothelial growth factor (vascular endothelial growth factor, VEGF), tumor necrosis factor-α (tumor necrosis factor-α, TNF-α)...

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Abstract

The invention discloses an aminocaproic acid medicine composition and pharmaceutical application thereof. The aminocaproic acid medicine composition contains aminocaproic acid and a natural product compound (I) which is separated from dried folium sennae and is of a novel structure. Only common deep-scald protection effects can be realized when the aminocaproic acid and the natural product compound (I) are individually used, but deep-scald protection effects can be obviously improved when the aminocaproic acid and the natural product compound (I) are used with each other, and accordingly the aminocaproic acid medicine composition can be developed to obtain deep-scald protection medicines. Compared with the prior art, the aminocaproic acid medicine composition and the pharmaceutical application have the advantages of outstanding substantial characteristics and obvious advancement.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of aminocaproic acid, in particular to a pharmaceutical composition of aminocaproic acid and its medical application. Background technique [0002] Aminocaproic acid Chinese aliases: 6-aminocaproic acid, ε-aminocaproic acid, aminocaproic acid, anti-fibrinolytic acid; English aliases: 6-AminocaoroicAcid, 6-AminohexanoicAcid, Acepramin, Epsilon-AminocaproicAcid, Amicar, Epsilon; white Or light yellow crystalline powder, soluble in water, its 3.52% aqueous solution is an isotonic solution, with a melting point of 204-207°C, which can hinder the formation of fibrinolytic enzymes, thereby inhibiting the dissolution of fibrin to achieve hemostasis. The drug is mainly used for fibrinolytic bleeding, such as brain, lung, uterus, prostate, adrenal gland, thyroid and other trauma or surgical bleeding. Early intraoperative medication or preoperative medication can reduce bleeding d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/58A61K31/352A61K31/197A61P17/02
CPCC07D311/58A61K31/197A61K31/352
Inventor 李晨露
Owner 李晨露
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