Dual-phase magnetic nano-composite scaffold material and preparation method thereof

Abstract

The invention discloses a dual-phase magnetic nano-composite scaffold material. The dual-phase magnetic nano-composite scaffold material is prepared by compositing a cartilago phase with a bone phase,wherein the cartilago phase contains polylactic acid and a natural polymer compound; and the bone phase contains polylactic acid, nano-hydroxyapatite and magnetic nanoparticles. The invention furtherdiscloses a preparation method of the dual-phase magnetic nano-composite scaffold material. The three-dimensional dual-phase magnetic nano-composite scaffold material is prepared from polylactic acid, the natural polymer compound, nano-hydroxyapatite and the magnetic nano particles by virtue of a low-temperature rapid forming technique and is integrated with the advantages of the four materials,is capable of promoting the adhesion and proliferation of cells, reducing the toxicity of degradation products and improving the biomechanical properties based on good osteoconduction and biocompatibility and is relatively beneficial to the adhesion growth and vascularization of solid cells, and the speed and effect of the coalescence between artificial cartilages transplanted at bone defect partsof a joint cartilage and a subchondral bone and the bones are greatly increased and improved.

Description

technical field [0001] The invention belongs to the technical field of biomedical composite materials, and in particular relates to a dual-phase magnetic nanocomposite support material and a preparation method thereof. Background technique [0002] Clinically, articular cartilage damage caused by various diseases, such as arthritis or trauma, is often accompanied by damage to subchondral bone. Therefore, the joint repair of cartilage and subchondral bone is better than the repair of cartilage alone. Scaffolds in bone tissue engineering are mainly three-dimensional porous shapes, and need to meet cell adhesion, regulation and interaction between cells, have certain mechanical properties and release bioactive molecules, and can promote the temptation and differentiation of seed cells and proliferation, such as forming a microenvironment for the differentiation of bone marrow mesenchymal stem cells into chondrocytes and osteoblasts, and promoting the formation of cartilage and ...

AI Technical Summary

Problems solved by technology

[0003] Bone and cartilage tissue engineering currently mainly includes three important components: seed cells, cytokines and scaffold materials. The scaffold material is the cell carrier and is the most basic element, and its biological characteristics are required to promote the formation of bone and cartilage tissue. Repair; ideal scaffold materials should include the following points: ①Good biocompatibility and low cytotoxicity; ②Controllable degradability; ③Appropriate pore structure; ④Good mechanical properties, which can bear the mechanical load of bone defects ; ⑤ can bear and cooperate with growth factors to promote cell activity, differentiation and secretion of extracellular matrix and other characteristics; ⑥ adhere to the surrounding tissue well, without obvious tissue rejection; and the existing scaffold materials are mostly single-layer composite scaffold materials And most of them use polylactic acid, nano-hydroxyapatite and magnetic nanoparticles as raw materials to prepare scaffold materials, but it is still difficult to meet the above requirements of relatively satisfactory scaffold materials

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