34results about How to "Improve biomechanical properties" patented technology

The invention provides II-type collagen joint cartilage fluid and a preparation method thereof. Bacteria, viruses and other hazardous substances of the joint cartilage are removed through degreasing-> serum removing-> surfactant treatment-> oxidant treatment-> disinfection and other links. Hybrid protein and other denatured protein of the cartilage are removed through acid hydrolysis, salt precipitation, dialysis and other processes, and high-purity and high-activity II-type collagen solution is prepared. Non-toxin and non-heat raw materials and auxiliary materials and isotonic solution are mixed in an appropriate ratio, and filled in a sterile non-heat disposable injector, to prepare II-type collagen joint cartilage fluid for disposable injection. Other components of the II-type collagen joint cartilage fluid comprise the auxiliary materials and the isotonic solution. The II-type collagen joint cartilage fluid can play the roles of lubrication, pain relieving and joint activity degree improving to the injured joints, fundamentally realizes the internal repair to the cartilage tissue, and is applicable to a patient with various joint cartilage injuries and all types of arthritis.

The invention relates to a medical material for orthopaedics in clinical medicine, in particular to a hollow titanium rod for supporting the collapse of the femoral head. At present, the accepted early treatment method of femoral head necrosis at home and abroad is core decompression, the remnant bone defect and femoral neck weak areas after core decompression can cause the supporting structure in the necrotic femoral head to be weakened, thus the collapse of the femoral head can not be prevented or corrected but can be quickened. The titanium screw rod of the invention is smooth, the outer diameter of the rod is 10mm, a through hole is arranged in the rod, the inner diameter of the through hole is 1.35mm, coarse threads are arranged at the tail of the screw rod, the length of the threads is 16-20mm, the diameter of a threaded core is 10mm, the outer diameter of the threads is 11mm, the distance between the threads is 1.75mm, the length of the whole screw rod is 75-110cm, and an inner hexagonal notch is arranged at the tail end. The product of the invention can be used for effectively preventing the collapse of the femoral head.

This invention relates to a biological reactor for constructing tissue engineered muscle tendon. The biological reactor is composed of a cell culture chamber, a control system, a liquid-change control system, and a parameter measurement system. The biological reactor can apply a pulse tension on the composite of cell and degradable material. The muscle tendon constructed by the biological reactor has a strain range of 4-15%, thus has excellent biological and mechanical properties. The biological reactor can also be used for culture of other tissues and cells.

The invention relates to the technical field of medical biological materials, in particular to a bioactive degradable coral hydroxyapatite artificial bone and a preparation method thereof. The artificial bone comprises a bracket, wherein bone-inducing active cell factors and controlled release formulations are attached onto the bracket; the bracket comprises a bracket body; the bracket body is coral; a hydroxyapatite layer coats the surface of the bracket body; the bone-inducing active cell factors are made of recombinant human bone morphogenetic protein-2 mature peptide; the controlled release formulations are selected from collagen, fibronectin, hyaluronic acid and the like; the bracket is granular or cylindrical; the aperture range of micropores is 77-180 microns; the porosity of the micropores is 8-11%. According to verification results of the National Institute for the Control of Pharmaceutical and Biological Products (verification report numbers comprise QZ200701428 and QZ200804480) and the National Institutes for Food and Drug control (verification report number is QZ201206312), the artificial bone is excellent bone graft substitute.

The invention discloses a medical degradable zinc alloy sheet for guiding bone regeneration and a preparation method thereof. According to the technical scheme, zinc alloy is processed, processes of smelting, casting, annealing, extruding, rolling, leveling, punching and the like are carried out to prepare the zinc alloy sheet with the thickness of 0.05 mm to 0.5 mm, the method is used for developing the novel medical degradable zinc alloy sheet for guiding bone regeneration, the barrier film has good biocompatibility, the degradable requirement is met, the mechanical strength being 300 MPa ormore and the capability of maintaining the regeneration space are achieved, and the method can be applied to the field of biomedical degradable barrier films for guiding bone regeneration and all medical application fields based on bone defect repair.

The invention discloses a hollow titanium bar provided with a fixing device and used for supporting the femoral head and preventing the femoral head from collapse. The hollow titanium bar comprises abar body and the fixing device, wherein the bar body is integrally formed and is an octagonal prism; a hydroxyapatite coating is formed on the outer surface of the bar body; a through hole is formed in the axial direction of the bar body; coarse threads are arranged at the tail part of the bar body; an inner hexagonal notch is formed in the tail end of the bar body and communicated with the through hole; the fixing device is connected with the tail end of the bar body. The titanium bar for supporting the femoral head is implanted into the collapse position of the femoral head and plays a roleof mechanical support, thereby improving biomechanical characteristics of the femoral head and the neck and preventing the femoral head from collapse; the titanium bar for supporting the femoral headis of a hollow structure and can play a role of reducing pressure of the femoral head for a long time, the hydroxyapatite coating on the outer surface of the titanium bar body is good in compatibilitywith human tissue, and the fixing device is arranged at the tail end of the titanium bar, so that the titanium bar is effectively prevented from loosening and slipping.

The invention discloses a Chinese medicinal composition for accelerating fracture healing, and relates to the technical field of Chinese medicaments. The Chinese medicinal composition is prepared from the following Chinese medicinal materials in parts by weight: 12 to 15 parts of frankincense, 12 to 15 parts of myrrh, 12 to 15 parts of Chinese angelica, 4 to 6 parts of asarum, 12 to 18 parts of dragon's blood, 10 to 14 parts of garden balsam stem, 8 to 12 parts of pseudo-ginseng, 12 to 15 parts of beautiful sweetgum fruit, 12 to 15 parts of unprocessed kusnezoff monkshood root, and 4 to 8 parts of borneol. The Chinese medicinal composition related by the invention has an effect of improving the anti-compression anti-fracture biomechanical character of a patient with osteoporosis.

The invention belongs to the technical field of in-vitro establishment of tissue engineering cartilages, more particularly to an experimental method for establishing tissue engineering cartilage in vitro by taking a knee-joint cartilage unit of a rabbit as a seed cell. The experimental method comprises the following steps of: taking a keen joint of a rabbit, repeatedly cutting the joint cartilage into fragmentized tissues, washing, removing supernatant away and putting in a sterile conical flask for later use; adding dispase and II-type collagenase into the conical flask according to 12mL DMEM-F12 culture solution/g cartilage, stirring and digesting to form a digested suspension solution; filtering and centrifuging the digested suspension solution, adding a primary chondrocyte culture solution to prepare a sterile chondrocyte suspension solution, and carrying out sodium alginate gel three-dimensional culture on the obtained cartilage unit to construct the tissue engineering cartilage. The invention has the beneficial effects that: the cartilage unit has stable form and multiplication situation in the in-vitro long-term culturing process, the physiological function of substrate ingredients, such as secreted II-type collagen, and the like is improved, and the effect of repairing cartilage injury by adopting a tissue engineering method is expectedly accelerated.

The invention discloses a composition containing oligopeptide and D-glucosamine hydrochloride for patients with bone injury. The composition contains oligopeptide, D-glucosamine hydrochloride and a traditional Chinese medicine extract, wherein the oligopeptide is the mixture of marine collagen peptide and marine ossein peptide, and the traditional Chinese medicine extract is the extract of peach kernel, lentinus edodes and dried orange peel. The composition not only can maintain the nutritive equilibrium of patients with bone injury, but also can improve the biomechanical characteristics of compression resistance and fracture resistance of patients with osteoporosis.

The invention belongs to the technical field of artificial limb repair and orthotics and discloses a pure-titanium outer-hanging osseointegration artificial limb implant. The implant comprises a fixing cap and a thread structure; the thread structure is formed in the fixing cap. According to the innovative outer-hanging osseointegration artificial limb, the bony joint of titanium and bone cortex can succeed as well to provide a fixing position, the tissue in the marrow cavity is not harmed, non-reversibility bone absorption caused when the bone cortex is subjected to stress shielding in a traditional artificial limb is reduced, and the exterior of the titanium artificial limb and the skin soft tissue can achieve good soft tissue integration; in addition, the space to vary the appearance ofthe outer-hanging implant is wide, a 3D printing technology of combining CT scanning with selective laser melting (SLM) and other methods can be used for customizing the porous titanium cap artificial limb implant, the inner face of the outer-hanging artificial limb is better matched with the appearance of the limb stub bone, the tissue in the implant grows into the inner face of the outer-hanging artificial limb, and the exterior better meets the demand for a more natural biological appearance and dynamics requirements.

The invention relates to a Chinese medicinal composition for promoting fracture healing. The composition is prepared from the following Chinese medicinal materials in part by weight: 30 to 40 parts of yellow gardenia, 15 to 20 parts of monkshood, 12 to 18 parts of frankincense, 12 to 18 parts of myrrh, 15 to 20 parts of kusnezoff monkshood root, 15 to 20 parts of rhizoma cyperi, 20 to 25 parts ofsafflower, 8 to 12 parts of pseudo-ginseng, and 20 to 30 parts of honey. The Chinese medicinal composition can be used for preventing bone mass loss of osteoporotic fracture patients and keeping approximately normal femoral density, and has remarkable effects of keeping bone form and improving the bone forming rate.

The present invention discloses a topical drug combination for promotion of fracture healing and application, the topical drug combination comprises an active component and a medicinal supplementary material, and the active component is prepared from root of wallich swallowwort and alangium platanifolium as Chinese herbal medicine raw materials. The topical drug combination can promote the fracture healing, and improve the biomechanical characteristics of compression resistance and fracture resistance of bones of elderly osteoporotic patients through increase of femoral maximum load and elastic ratio of osteoportic fracture patients.

The invention discloses a portable osteoporosis treatment instrument based on Internet of Things. The portable osteoporosis treatment instrument includes a main body and a treatment pad. According tothe osteoporosis treatment instrument, a modular integrated circuit and portable design are adopted, a remote mobile payment and control technology based on the Internet of Things is utilized, therefore, realistic requirements of various sites (such as communities and families) and different users (medical institutions at all levels or individuals) on osteoporosis treatment equipment are met, timeand costs of medical treatment of patients can also be greatly reduced, risks of fractures associated with going to hospital and back are reduced to the maximum degree, and optimization and allocation of rehabilitation medical resources of whole society can be promoted. After low-frequency pulse magnetic fields with specific waveforms, frequencies and intensities are sent by the osteoporosis treatment instrument and act on human-body bones, the activity of osteoblasts can be promoted and improved, cell behaviors, collagen aggregation and collagen arrangement are influenced, thus, the bones adaptively change, forming and rebuilding of the bones are accelerated, bone microstructures are improved, bone mineral density is increased, biomechanical characteristics of the bones are enhanced, bone metabolism is improved, calcium absorption of the bones is promoted, and therefore significant therapeutic effects are achieved.