Medical degradable zinc alloy sheet for guiding bone regeneration and preparation method thereof

A technology for guiding bone regeneration and zinc alloys, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of biological toxicity, poor mechanical properties of materials, poor mechanical properties of pure zinc, etc., to promote bone growth and healing , good biocompatibility, excellent mechanical properties

Inactive Publication Date: 2018-08-14
YANTAI NANSHAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main reason for restricting metal zinc as a degradable medical material for clinical application is that the mechanical properties of pure zinc are poor, and its tensile strength is less than 100Mpa. Clinically, bone tissue engineering implant materials require its mechanical strength to reach more than 200MPa, and its elongation More than 10%, the mechanical properties of pure zinc can not meet the requirements of clinical use
Patent 201510575728.1 "Application of Magnesium Materials as Oral GTR or GBR Membrane Materials" proposes an oral guided bone regeneration membrane material prepared by micro-arc oxidation coating on AZ31 magnesium alloy. The degradation rate of the magnesium alloy guided bone regeneration memb

Method used

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  • Medical degradable zinc alloy sheet for guiding bone regeneration and preparation method thereof
  • Medical degradable zinc alloy sheet for guiding bone regeneration and preparation method thereof
  • Medical degradable zinc alloy sheet for guiding bone regeneration and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] For the preparation of the biodegradable zinc alloy flakes for guided bone regeneration with the composition of Zn-1%Li, the mass fraction of Li in the zinc alloy solution is 1%, and the balance is Zn proportioning material, and then the material is added to the crucible, Melt at 450°C and stir evenly to obtain a zinc alloy melt; refine the above zinc alloy melt, let it stand, and cool it after pouring at 450°C to obtain a zinc alloy ingot; then cast the obtained zinc alloy ingot Put it in a heat treatment furnace, heat it at 200°C for 12 hours, and then quench it with water to obtain a zinc alloy ingot that has been homogenized and annealed; put the obtained zinc alloy ingot into a heat treatment furnace at 200°C for 30 minutes, and put it Put it into the extrusion cylinder, extrude the heated zinc alloy ingot at an extrusion speed of 0.5m / min, the extrusion ratio is 50:1, and obtain an extruded sheet with a thickness of 1mm; remove the surface of the extruded sheet Im...

Embodiment 2

[0030] Aiming at the preparation of biodegradable zinc alloy flakes for guided bone regeneration with the composition of Zn-0.5%Ag-1.0%Li, the mass fraction of Li in the zinc alloy solution is 1%, the mass fraction of Ag is 0.5%, and the balance is Zn Proportioning the materials, then adding the materials into the crucible, melting at 650°C, adding lithium and silver in turn, stirring evenly, to obtain a zinc alloy melt; refining the above zinc alloy melt, standing still, and pouring at 550°C After cooling, zinc alloy ingots are obtained; then the prepared zinc alloy ingots are placed in a heat treatment furnace, kept at 350°C for 56 hours, and then water quenched to obtain zinc alloy ingots treated by homogenization annealing; the obtained zinc alloy ingots are Put the alloy ingot into a heat treatment furnace at 350°C for 90 minutes, put it into the extrusion cylinder, and extrude the heated zinc alloy ingot at an extrusion speed of 2m / min, with an extrusion ratio of 10:1, to...

Embodiment 3

[0033] Aiming at the preparation of biodegradable zinc alloy flakes for guided bone regeneration with the composition of Zn-0.05%Sr-0.05%Li, the mass fraction of Li in the zinc alloy solution is 0.05%, the mass fraction of Sr is 0.05%, and the balance is Zn Proportioning the materials, then adding the materials into the crucible, melting at 450°C, adding lithium and strontium in turn, stirring evenly, to obtain a zinc alloy melt; refining the above zinc alloy melt, standing still, and pouring at 450°C After cooling, zinc alloy ingots are obtained; then the prepared zinc alloy ingots are placed in a heat treatment furnace, kept at 200°C for 12 hours, and then water quenched to obtain zinc alloy ingots treated by homogenization annealing; the obtained zinc alloy ingots are Put the alloy ingot in a heat treatment furnace at 200°C for 30 minutes, put it into the extrusion cylinder, and extrude the heated zinc alloy ingot at an extrusion speed of 0.5m / min, with an extrusion ratio of...

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Abstract

The invention discloses a medical degradable zinc alloy sheet for guiding bone regeneration and a preparation method thereof. According to the technical scheme, zinc alloy is processed, processes of smelting, casting, annealing, extruding, rolling, leveling, punching and the like are carried out to prepare the zinc alloy sheet with the thickness of 0.05 mm to 0.5 mm, the method is used for developing the novel medical degradable zinc alloy sheet for guiding bone regeneration, the barrier film has good biocompatibility, the degradable requirement is met, the mechanical strength being 300 MPa ormore and the capability of maintaining the regeneration space are achieved, and the method can be applied to the field of biomedical degradable barrier films for guiding bone regeneration and all medical application fields based on bone defect repair.

Description

technical field [0001] The invention relates to a medical degradable zinc alloy sheet for guiding bone regeneration and a preparation method thereof, and belongs to the technical field of metal materials, biomedical materials and processing thereof. Background technique [0002] The research and development of medical materials is of great significance to the development of national economy and society. The use of new medical materials can make patients recover and greatly improve the quality of human life. [0003] Zinc and zinc alloys are a class of medical metal materials that have developed rapidly in recent years. They have good biocompatibility and have the function of degrading in biological fluid environments, which can meet the clinical requirements for degradable medical implant materials. Require. The main reason for restricting metal zinc as a degradable medical material for clinical application is that the mechanical properties of pure zinc are poor, and its te...

Claims

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Application Information

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IPC IPC(8): C22C18/00C22C1/02C22F1/16A61L27/58A61L27/50A61L27/04
CPCA61L27/047A61L27/50A61L27/58A61L2430/02C22C1/02C22C18/00C22F1/165
Inventor 余琨张玉戴翌龙顼向春房洪杰刘慧
Owner YANTAI NANSHAN UNIV
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