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Multi-purpose surgery biology patching material

A biological patch, multi-purpose technology, applied in the field of biomedical materials, can solve the problems of poor biocompatibility, cannot meet the biomechanical strength and biocompatibility at the same time, and achieve excellent mechanical properties, outstanding biomechanical properties, good The effect of biocompatibility

Inactive Publication Date: 2012-11-21
ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Synthetic polymers include polylactic acid (PLA), polyvinyl alcohol (PVA), polyethylene oxide (PEO), polycaprolactone (PCL) and polylactic-glycolic acid (PLGA), etc., which have high strength, mechanical Good performance, easy electrospinning and processing, but its biocompatibility is relatively poor
[0004] Therefore, the currently used electrospun fiber sheets made of a single natural polymer or synthetic polymer still cannot meet the needs of biomechanical strength and biocompatibility when used in surgical repairs.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1. Mix and dissolve 10% collagen, 10% silk fibroin, 70% polylactic acid (PLA), and 10% polycaprolactone (PCL) in hexafluoroisopropanol (HFIP) by mass percentage, heat slightly Stir until completely dissolved, and make an electrospinning solution with a mass volume ratio of 5% concentration;

[0021] 2. Put the prepared electrospinning solution in the drug delivery needle of the electrospinning device to make a sheet material with a porosity of 85-90% and a thickness of 0.8-1.2mm;

[0022] 3. The above-mentioned sheet-like material is dried and soaked repeatedly in 0.1M phosphate buffered saline (PBS) to remove possible residual solvent hexafluoroisopropanol (HFIP) to obtain the surgical patch material of the present invention.

Embodiment 2

[0024] 1. Mix and dissolve 30% collagen, 10% silk fibroin and 60% polylactic acid (PLA) in hexafluoroisopropanol (HFIP) according to the mass percentage, stir with slight heat until completely dissolved, and make a mass ratio of 5 % concentration of electrospinning solution;

[0025] 2. Put the prepared electrospinning solution in the drug delivery needle of the electrospinning device to make a sheet material with a porosity of 85-90% and a thickness of 0.8-1.2mm;

[0026] 3. The above-mentioned sheet-like material is dried and soaked repeatedly in 0.1M phosphate buffered saline (PBS) to remove possible residual solvent hexafluoroisopropanol (HFIP) to obtain the surgical patch material of the present invention.

Embodiment 3

[0028] 1. Mix and dissolve 20% of collagen, 30% of silk fibroin and 50% of polycaprolactone (PCL) in hexafluoroisopropanol (HFIP) according to the mass percentage, stir with slight heat until completely dissolved, and make mass The electrospinning solution with a concentration of 5%;

[0029] 2. Put the prepared electrospinning solution in the drug delivery needle of the electrospinning device to make a sheet material with a porosity of 85-90% and a thickness of 0.8-1.2mm;

[0030] 3. The above-mentioned sheet-like material is dried and soaked repeatedly in 0.1M phosphate buffered saline (PBS) to remove possible residual solvent hexafluoroisopropanol (HFIP) to obtain the surgical patch material of the present invention.

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PUM

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Abstract

The invention relates to a biological patching material for patching defective tissues or organs in various surgical operations, which is characterized in that a composition is prepared from collagen or / and fibroin and polylactic acid or / and polycaprolactone in percentage by mass by electrostatic spinning technology. The obtained biological patching material has the advantages of good biological mechanical property and biocompatibility, convenient preparation and low cost, can be prepared into random specifications, can be remolded and degraded in vivo, and can be used for various surgical patching operations.

Description

technical field [0001] The invention belongs to biomedical materials, and in particular relates to a biological patch material which can be used for repairing defective tissues or organs in various surgical operations. Background technique [0002] With the development of surgical medicine, repair materials are often required in various surgical operations. Such as the repair of ventricular septal defect and atrial septal defect in children with congenital heart disease, pericardium repair, blood vessel repair, hernia tension-free repair, pleural and peritoneal defect repair, dura mater defect repair and bladder repair, etc. Its own material is the most ideal, but the material that can be provided in the body is very limited. However, the currently used synthetic polymer materials such as polyester, carbon fiber, polyethylene, polypropylene, polytetrafluoroethylene, etc., although the short-term effect is relatively satisfactory, but there is generally a lack of growth and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12A61L31/06A61L31/04
Inventor 应大君陆海蒋波陈卫军
Owner ARMY MEDICAL UNIV
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