Core-shell drug-loaded nano-fiber dressing and preparation method thereof

Abstract

The invention belongs to the technical field of wound dressings, in particular to a core-shell drug-loaded nano-fiber dressing and a preparation method thereof. The invention provides the core-shell drug-loaded nano-fiber dressing, and the core-shell drug-loaded nano-fiber dressing is obtained through coaxial electrostatic spinning, and sustained release of drugs can be realized; a core layer is constituted by mel and polyvinyl alcohol, and a shell layer is constituted by epsilon-polylysine and polycaprolactone; due to a core-shell structure, the mel as a natural active substance can be effectively protected, an influence of an organic solvent on the active substance is avoided; through wrapping with polycaprolactone as a hydrophobic shell layer, the phenomenon that glutaraldehyde as a toxic and organic solvent is crosslinked with the polyvinyl alcohol can be avoided; the epsilon-polylysine is loaded on the shell layer, so that a good bacteria inhibition effect is achieved; and moreover, the epsilon-polylysine also can enhance interaction between cells and materials, is beneficial for adhesion and proliferation of the cells, and is high in biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of wound dressings, in particular to a core-shell drug-loaded nanofiber dressing and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body, which can protect the internal tissues of the human body from the harm of bacteria. Wounds caused by surgery, trauma and superficial burns need to be wrapped with dressings to prevent the invasion of bacteria, avoid wound inflammation and accelerate the wound healing process . However, traditional dressings such as gauze are inexpensive, but their high absorbency can lead to wound dehydration and enhanced bacterial growth, as well as possible secondary damage when the gauze is removed. In recent years, various novel wound dressings have been developed, such as films, hydrocolloids, hydrogels, and micro / nanofibers. Among them, electrospun nanofibrous membranes have great prospects in the field of wound dressings due ...

AI Technical Summary

Problems solved by technology

[0004] In view of this, the present invention provides a core-shell drug-loaded nanofiber dressing and a preparation method thereof, which are used to solve the need for electrospinning of honey mixed with hydrophilic polymers through chemical methods such as the use of toxic organic solvents such as glutaraldehyde. If the honey content in the electrospinning solution is too high, the spinnability of the electrospinning solution will be reduced.

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