Core-shell drug-loaded nano-fiber dressing and preparation method thereof

A drug-loaded nanometer and fiber technology, which is applied in the fields of medical formula, fiber chemical characteristics, medical science, etc., can solve the problem of reduced spinnability of electrospinning solution, so as to facilitate cell adhesion and proliferation, promote wound healing, and promote cell regeneration. The effect of adhesion

Inactive Publication Date: 2019-11-19
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of this, the present invention provides a core-shell drug-loaded nanofiber dressing and a preparation method thereof, which are used to solve the need for electrospinning of honey mixed with hydrophilic polymer

Method used

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  • Core-shell drug-loaded nano-fiber dressing and preparation method thereof
  • Core-shell drug-loaded nano-fiber dressing and preparation method thereof
  • Core-shell drug-loaded nano-fiber dressing and preparation method thereof

Examples

Experimental program
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Example Embodiment

[0054] Example 1

[0055] First prepare the inner tube solution: mix polyvinyl alcohol particles with a molecular weight of 140,000 and distilled water, the prepared mixed solution contains 15% (w / v) of polyvinyl alcohol, and the mixed solution is placed in a round bottom flask, and then Put the mixed solution into a silicon oil bath magnetic stirring pot and stir to obtain a polyvinyl alcohol solution. The setting temperature of the silicone oil bath magnetic stirring pot is 90℃, the stirring time is 3h, and the stirring speed is set to 300~500rpm; use a syringe to take 1mL honey into the reagent bottle, then add 19mL polyvinyl alcohol solution, and magnetically stir at 400rpm 12 to 24 hours, fully mixed into a homogeneous solution, that is, the inner tube solution, the volume fraction of honey in the inner tube solution is 5% (v / v).

[0056] Then prepare the outer tube solution: add ε-polylysine with a molecular weight of 3,600 to 4,300 and polycaprolactone with a molecular weig...

Example Embodiment

[0066] Example 2

[0067] First prepare the inner tube solution: mix polyvinyl alcohol particles with a molecular weight of 140,000 and distilled water, and the polyvinyl alcohol content of the prepared mixed solution is 15% (w / v), and the mixed solution is placed in a round bottom flask, and then Put the mixed solution into a silicon oil bath magnetic stirring pot and stir to obtain a polyvinyl alcohol solution. The setting temperature of the silicon oil bath magnetic stirring pot is 90℃, the stirring time is 3h, and the stirring speed is set to 300~500rpm; use a syringe to take 4mL honey into the reagent bottle, then add 16mL polyvinyl alcohol solution, and magnetically stir at 400rpm 12 to 24 hours, fully mixed into a homogeneous solution, that is, the inner tube solution, the volume fraction of honey in the inner tube solution is 20% (v / v).

[0068] Then prepare the outer tube solution: add ε-polylysine with a molecular weight of 3,600 to 4,300 and polycaprolactone with a mole...

Example Embodiment

[0078] Example 3

[0079] First prepare the inner tube solution: mix the polyvinyl alcohol particles with a molecular weight of 140,000 and distilled water, the prepared mixed solution contains 10% (w / v) polyvinyl alcohol, and the mixed solution is placed in a round bottom flask, and then Put the mixed solution into a silicon oil bath magnetic stirring pot and stir to obtain a polyvinyl alcohol solution. The setting temperature of the silicon oil bath magnetic stirring pot is 90℃, the stirring time is 3h, and the stirring speed is set to 300~500rpm; use a syringe to take 6mL honey into the reagent bottle, then add 14mL polyvinyl alcohol solution, and magnetically stir at 400rpm 12-24h, fully mix into a homogeneous solution, that is, the inner tube solution, the volume fraction of honey in the inner tube solution is 30% (v / v).

[0080] Then prepare the outer tube solution: add ε-polylysine with a molecular weight of 3,600 to 4,300 and polycaprolactone with a molecular weight of 70,...

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Abstract

The invention belongs to the technical field of wound dressings, in particular to a core-shell drug-loaded nano-fiber dressing and a preparation method thereof. The invention provides the core-shell drug-loaded nano-fiber dressing, and the core-shell drug-loaded nano-fiber dressing is obtained through coaxial electrostatic spinning, and sustained release of drugs can be realized; a core layer is constituted by mel and polyvinyl alcohol, and a shell layer is constituted by epsilon-polylysine and polycaprolactone; due to a core-shell structure, the mel as a natural active substance can be effectively protected, an influence of an organic solvent on the active substance is avoided; through wrapping with polycaprolactone as a hydrophobic shell layer, the phenomenon that glutaraldehyde as a toxic and organic solvent is crosslinked with the polyvinyl alcohol can be avoided; the epsilon-polylysine is loaded on the shell layer, so that a good bacteria inhibition effect is achieved; and moreover, the epsilon-polylysine also can enhance interaction between cells and materials, is beneficial for adhesion and proliferation of the cells, and is high in biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of wound dressings, in particular to a core-shell drug-loaded nanofiber dressing and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body, which can protect the internal tissues of the human body from the harm of bacteria. Wounds caused by surgery, trauma and superficial burns need to be wrapped with dressings to prevent the invasion of bacteria, avoid wound inflammation and accelerate the wound healing process . However, traditional dressings such as gauze are inexpensive, but their high absorbency can lead to wound dehydration and enhanced bacterial growth, as well as possible secondary damage when the gauze is removed. In recent years, various novel wound dressings have been developed, such as films, hydrocolloids, hydrogels, and micro / nanofibers. Among them, electrospun nanofibrous membranes have great prospects in the field of wound dressings due ...

Claims

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Application Information

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IPC IPC(8): A61L15/40A61L15/24A61L15/26A61L15/46A61L15/44D01F8/12D01F8/14D01F8/10D01F1/10
CPCA61L15/24A61L15/26A61L15/40A61L15/44A61L15/46A61L2400/12D01F1/10D01F8/10D01F8/12D01F8/14C08L77/04C08L67/04C08L29/04
Inventor 汤亚东蓝兴梓周颖苗小敏陈杰罗竣仁罗婷婷黄冬超梁成锋钟芷欣
Owner GUANGDONG UNIV OF TECH
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