Antibacterial medical metal material capable of being degraded in body fluid, and applications thereof

Abstract

The present invention provides a magnesium-copper alloy, which contains magnesium and copper, wherein the copper content is less than or equal to 3 wt%, and the balance is the magnesium. According to the present invention, the magnesium-copper alloy has characteristics of good biodegradability, satisfactory degradability, high biological safety, and excellent biomechanical property, has application values in medical fields of endosseous implants and the like, especially continuously and slowly releases metal ions with the bacterial inhibiting effect to the surrounding tissue through in vivo degradation, has effects of effective prevention and treatment of infections surrounding implants, and has a certain angiogenesis activity.

Description

technical field [0001] The invention relates to an alloy material, in particular to a body fluid degradable medical metal material with an antibacterial function that can be used as a medical implant material and its application. Background technique [0002] Medical metal materials have become commonly used internal fixation materials in orthopedics because of their excellent processing and forming properties and corrosion resistance, and are being widely used in clinical practice. However, current medical metal materials such as stainless steel and titanium alloys are all biologically inert materials. After implantation, they remain in the body as foreign bodies for a long time, which will cause different degrees of tissue reactions. It is now believed that the wear particles produced by metal materials in the body not only easily trigger the inflammatory reaction around the material and cause the occurrence of related diseases, but also may cause bone resorption or even o...

AI Technical Summary

Problems solved by technology

At present, there are two main research directions for this kind of antibacterial materials: 1) Use porous materials as carriers to load antibiotics, and use the materials as drug-loaded sustained-release systems for local treatment, but these materials still cannot solve the increasing number of multi-resistant drugs. Drug resistance of pathogenic bacteria to antibiotics

2) The surface of the inplant material is covered with an antibacterial coating containing antibacterial metal ions. The metal ions can be broad-spectrum antibacterial and have a good antibacterial effect. However, due to the thin thickness of the antibacterial coating, the degradation speed is fast and the action time is short. It is impossible to prevent and treat infection for a long time after surgery, and the bonding force between the coating and the implant material interface is often insufficient, which increases the hidden danger of fracture and delamination between the coating and the implant