The invention discloses applications of dihydro chromone framework compounds of CPQ-16, CPQ-17, CPQ-20, CPQ-22, CPQ-23 and CPQ-24 in preparing medicine for curing malignant tumors. According to experimental proof, any kind of the six compounds can kill a plurality kinds of tumor cells of human bodies effectively, the tumor cells comprise cervical cancer cells, non-small cell lung cancer cells, breast cancer cells, ovarian carcinoma cells, hepatoma carcinoma cells, nasopharyngeal carcinoma cells, gastric carcinoma cells, laryngocarcinoma cells, pancreatic cancer cells, melanoma cells, bladder cancer cells and leukemia cells. Besides, with increase of dosages of the compounds, injured and killed cancers are increased with the increase of the dosages, and thus the new applications are proofed and discovered in the medicine for curing malignant tumors, and a new application range is exploited. Besides, new medicine is provided for the malignant tumors, and the difficulty in the chemical treatment of diseases that tumor cells are tolerant of chemotherapeutics is solved.