The invention discloses a high-isolation four-port diversity antenna for mobile communication, which comprises a dielectric substrate, a grounding plane, a feed network, four electromagnetic dipoles, four L-shaped ribbons, four aerial microstrip transmission lines and a vertical copper line, wherein the four electromagnetic dipoles are annularly and evenly arranged on the square grounding place at intervals; one L-shaped ribbon and one aerial microstrip transmission line are arranged in each electromagnetic dipole, and the L-shaped ribbons are connected with the feed network through the aerial microstrip transmission lines; and one end of the vertical copper line is vertical to the center of the grounding plane. According to the invention, in the working bandwidth, the radiation efficiency of four modules all exceed 80 percent; and compared with the major traditional diversity antennas with a boardband mode, the high-isolation four-port diversity antenna can provide a wider radiation range in different polarization modes, thereby greatly improving the system property. In addition, when the high-isolation four-port diversity antenna is used for an array structure, additional angle flexibility can be formed in aspects of wave beam control and wave beam forming.