The invention relates to a preparation method of traditional Chinese preparation honeysuckle and radix scutellariae granules. The preparation method comprises the following steps of: (1) preparation of honeysuckle thin paste: decocting honeysuckle with water twice, filtering, concentrating under reduced pressure, adding ethanol, standing, recovering ethanol, and concentrating; (2) preparation of radix scutellariae thin paste: decocting radix scutellariae with boiling water twice, filtering, standing, filtering supernatant, adjusting the pH value of the filtrate with concentrated hydrochloric acid, standing, filtering out precipitates, adding water to the precipitates, stirring for dissolving, adjusting the pH value with a sodium hydroxide solution, adding equivalent ethanol, uniformly stirring, standing, filtering supernatant, recovering ethanol from filtrate, and concentrating; and (3) adding a proper amount of adjuvants to the honeysuckle thin paste and radix scutellariae thin paste, uniformly stirring, and granulating.