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New application of HuGu capsule in preventing glucocorticoid-induced osteoporosis

A kind of osteoporosis, secondary technology, applied in traditional Chinese medicine Hugu Capsule, the application field of osteoporosis diseases, can solve the problems affecting the health status and quality of life of patients, GIO adverse reactions, bone loss, etc., to improve the material Mechanical status, prevention of secondary osteoporosis, prevention of bone loss

Active Publication Date: 2010-11-24
GUANGDONG ANNOL PHARM CO LTD
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AI Technical Summary

Problems solved by technology

Dexamethasone (Dex) is a kind of GCs, which is widely used clinically because of its good anti-inflammatory and anti-immune effects, but long-term high-dose use of Dex can cause a series of serious adverse reactions such as GIO, even Even physiological doses of Dex can also cause osteoporosis syndrome such as bone loss
GIO first causes bone loss and then fractures, seriously affecting the health status and quality of life of patients
At present, most of the Western medicines used in the prevention and treatment of osteoporosis (osteoporosis, OP) take the local target as the site of action. This therapy has certain limitations in the treatment of OP, a metabolic disease with multiple causes and fruits.

Method used

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  • New application of HuGu capsule in preventing glucocorticoid-induced osteoporosis
  • New application of HuGu capsule in preventing glucocorticoid-induced osteoporosis
  • New application of HuGu capsule in preventing glucocorticoid-induced osteoporosis

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Embodiment Construction

[0051] Below in conjunction with accompanying drawing of description, further illustrate the present invention.

[0052] Hugu Capsule (HG) is based on the compatibility of "lord, minister, assistant, and envoy". It adopts the principles of nourishing liver and kidney, nourishing essence and blood, and regulating yin and yang. The method of analgesic and sedative, the traditional Chinese medicine compound capsule preparation processed by certain technology. Among them, Radix Polygoni Multiflori and Epimedium nourish the liver and kidney, benefit essence and blood, and dispel wind-dampness, which are called "monarch drugs" in this prescription; rehmannia glutinosa and tortoise shell nourish kidney yin, nourish blood and nourish yin, and are called "minister drugs" in the prescription. "; then "assisting" with Morinda officinalis, Eucommia, Dipsacus, Drynaria, etc. to invigorate the liver and kidney, strengthen the bones and muscles, and the antirheumatic drugs strengthen the eff...

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Abstract

The invention relates to a new application of a HuGu capsule (HG) in preventing glucocorticoid-induced osteoporosis (GIO), belonging to the technical field of traditional Chinese medicine application. The invention discusses HG prevention effect towards GIO induced by glucocorticoids (GCs) based on bone histomorphometry. The experimental result proves that the glucocorticoids (GCs) can induce cortical bone loss of a rat in short time, after HG intervention is carried out for 45d, the GCs is prevented from inducing the cortical bone loss of the rat, thereby providing experimental proof for the new application of the HG in preventing the GIO.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine application, and in particular relates to the application of traditional Chinese medicine Hugu Capsule in preventing osteoporosis caused by glucocorticoids. Background technique [0002] Glucocorticoids (GCs) are a class of drugs that are widely used clinically, but high-dose use of GCs may lead to various complications, among which GCs-induced secondary osteoporosis (glucocorticoid-induced osteoporosis, GIO) is one. Dexamethasone (Dex) is a kind of GCs, which is widely used clinically because of its good anti-inflammatory and anti-immune effects, but long-term high-dose use of Dex can cause a series of serious adverse reactions such as GIO, even Even physiological doses of Dex can also cause osteoporosis syndrome such as bone loss. GIO first causes bone loss and then fractures, seriously affecting the health status and quality of life of patients. At present, most of the w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/48A61P19/10A61K35/56A61K35/586
Inventor 曾昭利
Owner GUANGDONG ANNOL PHARM CO LTD
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