Polymethyl methacrylate bone cement and preparation method thereof

A technology of polymethyl methacrylate and methyl methacrylate, which is used in medical science, prosthesis, tissue regeneration, etc., can solve the problems of incapability of arbitrary plasticity and large heat release.

Active Publication Date: 2018-06-01
BEIJING ALLGENS MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is to solve the existing polymethyl methacrylate bone cement, that is, the problem that PMMA bone cement emits too much heat and cannot be arbitrarily plasticized during use.

Method used

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  • Polymethyl methacrylate bone cement and preparation method thereof
  • Polymethyl methacrylate bone cement and preparation method thereof
  • Polymethyl methacrylate bone cement and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0094] The polymethyl methacrylate bone cement provided in this embodiment, each component and its dosage are shown in Table 1 and Table 2, wherein:

[0095] The molecular weight of the polymethyl methacrylate (i.e. PMMA) used is 150,000, the molecular weight of the used methyl methacrylate-styrene block copolymer (i.e. ps-b-mma) is 100,000, and the block ratio PMMA / PS =80:20;

[0096] In the liquid component, the stabilizer is hydroquinone and p-tert-butylcatechol, and the accelerator is N,N-dimethyl-p-toluidine.

[0097] Its preparation method comprises the following steps:

[0098] After mixing polymethyl methacrylate, methyl methacrylate-styrene block copolymer, contrast agent, initiator and colorant, solid component A is obtained;

[0099] Prepare mineralized bone collagen, and its preparation method comprises the following steps:

[0100] S1: dissolving type I collagen in hydrochloric acid to prepare a collagen acid solution, wherein the collagen concentration is 0.01...

Embodiment 2

[0109] The preparation steps of embodiment two are basically the same as embodiment one, the difference is:

[0110] The molecular weight of polymethyl methacrylate is 260,000, the molecular weight of methyl methacrylate-styrene block copolymer is 300,000, and the block ratio PMMA / PS=60:40; In the step of preparing mineralized collagen:

[0111] S1: dissolving collagen in nitric acid to prepare an acid solution of collagen, wherein the concentration of collagen is 0.5g / mL;

[0112] S2: Continuously stirring the solution obtained in step S1, slowly adding the solution containing calcium ions dropwise, the amount of calcium ions added is 2 mol of calcium ions corresponding to each gram of collagen;

[0113] S3: Continue to stir the solution obtained in step S2, slowly drop the solution containing phosphate ions, the molar ratio of the amount of phosphate ions added to the amount of calcium ions added in step S2 is Ca / P=2 / 1;

[0114] S4: same as embodiment one;

[0115] S5: The m...

Embodiment 3

[0119] The preparation steps of embodiment three are basically the same as embodiment two, and the difference is:

[0120] The molecular weight of polymethyl methacrylate is 200,000, the molecular weight of methyl methacrylate-styrene block copolymer is 200,000, and the block ratio PMMA / PS=70:30;

[0121] In the step of preparing mineralized collagen:

[0122] In S6, the mineralized collagen provided by S5 is mixed with the L-polylactic acid solution, and the preparation method includes the following steps:

[0123] (1) Preparation of L-polylactic acid solution:

[0124] Put the L-polylactic acid in the reaction kettle and add dimethyl sulfoxide to ensure that the concentration can reach 0.15g / mL.

[0125] Put the reaction kettle into a water bath and heat it. The temperature of the water bath is 40°C. When the solution in the reaction kettle becomes transparent, without stratification and no agglomeration, the L-polylactic acid solution is obtained.

[0126] (2) adding min...

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Abstract

The invention relates to a polymethyl methacrylate bone cement and a preparation method thereof. Concretely, the bone cement comprises a solid component and a liquid component. The solid component comprises a solid component A including polymethyl methacrylate, a methyl methacrylate-styrene segmented copolymer, a contrast agent, and an initiator; and a solid component B including mineralized collagen. The liquid component includes methyl methacrylate, a stabilizer and an accelerating agent. Through control of the molecular weight and ratio of the components, it is ensured that the obtained PMMA bone cement doesn't release a large amount of heat during application, thereby preventing damage to the surrounding bone tissue. The bone cement is suitable in viscosity and has random plasticity. Through addition of mineralized collagen which is excellent in osteogenic activity, the mechanical property and biocompatibility of bone cement are improved, and the bone cement is excellent in osseointegration capability and low in elastic modulus.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a polymethyl methacrylate bone cement and a preparation method thereof. Background technique [0002] Polymethyl methacrylate bone cement, often called PMMA bone cement, is widely used in various orthopedic surgeries, such as vertebroplasty, joint replacement, and repair of tumor or post-traumatic bone defects. [0003] At present, a variety of PMMA bone cement products are marketed and used clinically both at home and abroad. However, the existing PMMA bone cement still has relatively large defects, which are mainly manifested in two aspects: 1. The elastic modulus of PMMA bone cement is too high; 2. The biological inertia of PMMA makes it unable to form osseointegration with bone tissue, resulting in The interface between the two is obvious, the bonding strength is poor, and it is easy to cause loosening. [0004] At present, a lot of research has been done on the b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/50A61L27/58A61L27/24A61L27/54
CPCA61L27/16A61L27/24A61L27/50A61L27/54A61L27/58A61L2300/252A61L2300/412A61L2430/02C08L33/12C08L25/14
Inventor 崔云仇志烨宋天喜朱金亮胡艳丽何志敏崔菡
Owner BEIJING ALLGENS MEDICAL SCI & TECH
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