Reductively biodegradable type honeycomb polyurethane support, and preparation method and application thereof

A technology of polyester polyurethane and polyurethane, which is applied in the field of bioreductive and degradable cellular polyurethane scaffolds and its preparation, can solve the problems of small pore diameter, complicated process, and low porosity, and achieve uniform pore size distribution and controllable performance The effect of strong resistance and good biomechanical properties

Inactive Publication Date: 2014-01-08
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, unidirectional freeze-drying method, microneedle array template method, rapid prototyping method and ion gelation method have been developed. Although some progress has been made in their research, there are still shortcomings such as small pore diameter or low porosity.
Recently, the Chinese patent No. 201010602753.1 discloses a technology of using plant porous tissue as a template to prepare a honeycomb porous scaffold, which can obtain a honeycomb pore structure with a pore size ranging from 10 to 160 microns. complex

Method used

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  • Reductively biodegradable type honeycomb polyurethane support, and preparation method and application thereof
  • Reductively biodegradable type honeycomb polyurethane support, and preparation method and application thereof
  • Reductively biodegradable type honeycomb polyurethane support, and preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0046] The preparation method of bioreducible degradable honeycomb polyurethane support comprises the following steps:

[0047] 1) Synthesis of double-terminated hydroxyl polycaprolactone containing disulfide bonds:

[0048] Add anhydrous initiator 2,2′-dithiodiethanol and monomer caprolactone in a molar ratio of 1:12, and then add the catalyst stannous isooctanoate with a monomer caprolactone molar weight of 5‰ , reacting at 125°C for 30 hours under the protection of argon, purifying the product obtained by the reaction by dissolving in dichloromethane / precipitating with ether, and then drying in vacuum to obtain a disulfide bond-containing double-terminal hydroxyl polycaprolactone;

[0049] 2) Synthesis of polyester polyurethane containing disulfide bonds:

[0050] Put 2,2′-dithiodiethyl isocyanate and the disulfide bond-containing double-terminal hydroxyl polycaprolactone obtained in step 1) at a molar ratio of 1.02:1 in a reaction vessel as reactants, and then add Water ...

Embodiment 2

[0060] The preparation method of bioreducible degradable honeycomb polyurethane support comprises the following steps:

[0061] 1) Synthesis of double-terminated hydroxyl polycaprolactone containing disulfide bonds:

[0062] Add anhydrous initiator 2,2′-dithiodiethanol and monomer caprolactone in a molar ratio of 1:6 into the reaction vessel, and then add catalyst stannous isooctanoate with 1% molar amount of monomer caprolactone , reacting at 110°C for 48 hours under the protection of argon, purifying the product obtained by the reaction by dissolving in dichloromethane / precipitating with ether, and then drying in vacuum to obtain a disulfide bond-containing double-terminal hydroxyl polycaprolactone;

[0063] 2) Synthesis of polyester polyurethane containing disulfide bonds:

[0064] Put 2,2′-dithiodiethyl isocyanate and the disulfide-bond-containing double-terminal polycaprolactone obtained in step 1) in a molar ratio of 1.05:1 in a reaction vessel as reactants, and then ad...

Embodiment 3

[0070] The preparation method of bioreducible degradable honeycomb polyurethane support comprises the following steps:

[0071] 1) Synthesis of double-terminated hydroxyl polycaprolactone containing disulfide bonds:

[0072] Add anhydrous initiator 2,2′-dithiodiethanol and monomer caprolactone in a molar ratio of 1:18, and then add catalyst stannous isooctanoate with a monomer caprolactone molar weight of 5‰ , reacting at 120°C for 40 hours under the protection of argon, purifying the product obtained by the reaction by dissolving in dichloromethane / precipitating with ether, and then drying in vacuum to obtain a disulfide bond-containing double-terminal hydroxyl polycaprolactone;

[0073] 2) Synthesis of polyester polyurethane containing disulfide bonds:

[0074] Put dithiodimethylisocyanate and disulfide bond-containing double-terminated polycaprolactone obtained in step 1) in a reaction vessel at a molar ratio of 1.04:1 as reactants, and then add anhydrous toluene to form mas...

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Abstract

The invention discloses a reductively biodegradable type honeycomb polyurethane support, and a preparation method and application thereof. The preparation method comprises: taking 2,2'-dithiodiethanol as an initiator, employing a ring-opening polymerization method to synthesize double-hydroxy-terminated polycaprolactone containing disulfide bonds; reacting with diisocyanate containing a disulfide bond to form polyester type polyurethane containing disulfide bonds; then dipping a biological template wisteria sinensis with a sodium chloride solution and calcining to obtain a negative template porous sodium chloride of wisteria sinensis; and finally immersing the negative template porous sodium chloride of wisteria sinensis with a waterless organic solution of the polyester type polyurethane containing disulfide bonds, drying and removing the negative template to obtain the honeycomb polyurethane support, wherein the molecular structural formula of the polyurethane is shown in the description. The reductively biodegradable type honeycomb polyurethane support has the advantages of simple technology, easy batch preparation, and strong biodegradation controllability; and the honeycomb structure is beneficial to transportation of substances inside or outside the support, the support can be used as a porous support for tissue regeneration repair, and belongs to a tissue engineering support material with excellent comprehensive performances.

Description

technical field [0001] The invention relates to the field of biomaterials, in particular to a bioreductive and degradable cellular polyurethane scaffold and its preparation method and application. Background technique [0002] Tissue engineering is an emerging regenerative medicine technology, which uses the basic principles and methods of engineering and biology to research and develop a type of technology that can repair, improve and replace the functions of human tissues or organs. It has high hopes in the field of tissue / organ structural repair and functional recovery. Tissue engineering technology is to plant specific cells on porous scaffolds and culture them in vitro or in vivo to form tissues / organs with specific structures to restore their functions. Porous scaffolds play a crucial role in determining the structure and function of engineered tissues, so the development of biomimetic porous scaffolds with dual spatial structure and material functional properties is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/50C08J9/26C08L75/06C08G18/77C08G18/42C08G18/24C08G63/688C08G63/08C08G63/85
Inventor 钱军民金欣霞胥伟军柳雪峰
Owner XI AN JIAOTONG UNIV
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