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Nanometer artificial bone framework with transverse gradient hole structure and preparation method thereof

A gradient hole, artificial bone technology, applied in bone implants, medical science, prosthesis, etc., can solve the problems of nano-artificial bone scaffolds that have not been reported in the literature, and achieve good biomechanical properties, easy access, and high cell proliferation rate effect

Inactive Publication Date: 2012-05-02
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There are no reports of nanoartificial bone scaffolds with laterally gradient pore structures like natural bone

Method used

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  • Nanometer artificial bone framework with transverse gradient hole structure and preparation method thereof
  • Nanometer artificial bone framework with transverse gradient hole structure and preparation method thereof
  • Nanometer artificial bone framework with transverse gradient hole structure and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: Prepare the nano-hydroxyapatite / polycaprolactone artificial bone scaffold of the transverse gradient pore structure of 10% HA

[0038] Use a stainless steel sieve to sieve the salt into 100um-200um and 200um-300um particles for later use. Heat 3 g of HA / PCL composite material with HA content of 10% to 100°C to melt, add 30mL solvent dimethylacetamide to it, raise the temperature to 120-130°C, and stir slowly until the sample becomes a solution-like substance. Add 12 g of table salt with a particle size of 200-300 μm therein, and keep stirring so that the table salt is evenly distributed in the solution, and at the same time, let the solvent evaporate gradually. After the solvent evaporates completely, take the sample out, put it into a polytetrafluoroethylene tube with an inner diameter of 6mm and a wall thickness of 1mm, and then squeeze it from the upper and lower ends to the middle with a polytetrafluoroethylene rod with a diameter of 6mm, so that The ...

Embodiment 2

[0039] Example 2: Preparation of nano-hydroxyapatite / polycaprolactone artificial bone scaffold with 20% HA transverse gradient pore structure.

[0040] Use a stainless steel sieve to sieve the salt into 100um-200um and 200um-300um particles for later use. Heat 3.5g of HA / PCL composite material with HA content of 20% to 100°C to melt, add 30mL solvent dimethylacetamide to it, raise the temperature to 120-130°C, and stir slowly until the sample becomes a solution-like substance . 12.5 g of table salt with a particle size of 200-300 μm was added thereto, stirring continuously so that the table salt was evenly distributed in the solution, and at the same time, the solvent was gradually evaporated. After the solvent evaporates completely, take the sample out, put it into a polytetrafluoroethylene tube with an inner diameter of 6mm and a wall thickness of 1mm, and then squeeze it from the upper and lower ends to the middle with a polytetrafluoroethylene rod with a diameter of 6mm, ...

Embodiment 3

[0041] Example 3: Preparation of nano-hydroxyapatite / polycaprolactone artificial bone scaffold with 30% HA transverse gradient pore structure.

[0042] Use a stainless steel sieve to sieve the salt into 100um-200um and 200um-300um particles for later use. Heat 3g of HA / PCL composite material with HA content of 30% to 100°C to melt, add 30mL solvent dimethylacetamide to it, raise the temperature to 120-130°C, and stir slowly until the sample becomes a solution-like substance. 13.7 g of table salt with a particle size of 200-300 μm was added thereto, stirring continuously so that the table salt was evenly distributed in the solution, and at the same time, the solvent was gradually evaporated. After the solvent evaporates completely, take the sample out, put it into a polytetrafluoroethylene tube with an inner diameter of 6mm and a wall thickness of 1mm, and then squeeze it from the upper and lower ends to the middle with a polytetrafluoroethylene rod with a diameter of 6mm, so t...

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Abstract

The invention relates to the technical field of the medical artificial bone grafting material. At present, no documents available report a nanometer artificial bone framework with a transverse gradient hole structure which is the same as a natural bone. The invention aims to provide a nanometer artificial bone framework which has good bioactivity, excellent mechanical property and the transverse gradient hole structure which is the same as a natural bone. The preparation method comprises the steps of: dissolving hydroxyapatite (HA) in a salt (NaCl) solvent to prepare a HA sol; then dissolving polycaprolactone (PCL) slowly in the HA sol; then heating and removing the solvent at a higher temperature; and finally casting layer by layer to a special mould to prepare a HA / PCL composite material. In the invention, the artificial bone framework which is similar to the structure of the natural bone and has the transverse gradient hole structure is obtained and the cells on the prepared artificial bone framework have higher reproduction rate and the framework has good biomechanical properties.

Description

technical field [0001] The invention relates to the technical field of medical artificial bone graft materials, in particular to a nano-hydroxyapatite / polycaprolactone artificial bone scaffold with a transverse gradient pore structure and a preparation method thereof. Background technique [0002] At present, bone transplantation has become the second only to blood transfusion in human tissue transplantation, widely distributed in many fields such as orthopedics, oral cavity and craniofacial. People have used polycaprolactone (poly-e-caprolactone, PCL) to construct three-dimensional bone tissue engineering porous scaffolds and achieved success. These degradable materials have been proved to have good biocompatibility. And hydroxyapatite (hydroxyapatite, HA) has good biocompatibility and bioactivity, and can form a strong chemical bond with bone on the interface after being implanted into bone tissue, and has osteoconduction and osteoinductivity. HA block ceramics have been ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28A61L27/46
Inventor 许硕贵周斌夏琰唐骏杜艾卢春闻张猛
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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