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Preparation method for artificial cartilage

A cartilage and artificial technology, applied in the field of artificial cartilage preparation, can solve the problems of poor microscopic pore structure, poor affinity of artificial cartilage materials, etc., to meet the requirements of cartilage cell adhesion, good biomechanical properties, and good biocompatibility. Effect

Active Publication Date: 2017-04-05
XIANGYA HOSPITAL CENT SOUTH UNIV
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Problems solved by technology

[0007] In view of the defects of poor microscopic pore structure and poor affinity of artificial cartilage materials in the existing artificial cartilage, the purpose of the present invention is to provide a preparation with good biocompatibility, biomechanical properties similar to cartilage, high pore system rate, and The method of artificial cartilage tissue with regular through-holes and small through-holes, the prepared artificial cartilage tissue has good biocompatibility, can make bone cells grow into the interior of the cartilage, and perfectly integrate with the artificial cartilage

Method used

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  • Preparation method for artificial cartilage

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Embodiment 1

[0032] 1) Using polyamide polymer materials as raw materials, a pore scaffold with a three-dimensional network structure was first printed by SLS selective laser sintering technology (such as figure 1 described), the pore skeleton structure is stable, and the shape can be designed according to needs.

[0033] 2) Adding nano-hydroxyapatite powder into the PVA solution, stirring and mixing continuously, to make HA-PVA composite liquid, controlling the HA content to 5wt%, and the PVA content to 15wt%.

[0034] 3) Invert the prepared HA-PVA composite solution in the pore support, and inject the compound into the mold after the HA-PVA composite solution completely penetrates into the pore support; place the mold in a ‐20°C refrigerator for 10 hours , and then thawed at room temperature for 2 hours, this is a freeze-thaw cycle, repeated 5 times in this way, increasing the intermolecular cross-linking, and obtaining the artificial cartilage / scaffold complex;

[0035] 4) Soak the art...

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Abstract

The invention provides a preparation method for artificial cartilage. According to the method, a non water-soluble organic macromolecule material is prepared into a three-dimensional network-shaped porous support through 3D printing; meanwhile, a PVA solution is mechanically mixed with nano-hydroxyapatite powder, and an HA-PVA composite solution is obtained; then the HA-PVA composite solution is used for performing mold reversing on the three-dimensional network-shaped porous support, after the HA-PVA composite solution is made to permeate into the three-dimensional network-shaped porous support, the HA-PVA composite solution permeating into the three-dimensional network-shaped porous support is placed into an artificial cartilage mold, and an artificial cartilage / porous support composite body is obtained through a repeated freezing and thawing method; and the porous support of the obtained the artificial cartilage / porous support composite body is selectively dissolved through a solvent, and the artificial cartilage is obtained. The prepared artificial cartilage is good in biocompatibility, the biomechanical performance is close to that of cartilage, the porosity rate is high, regular through large holes and a small communicating hole system are achieved, and bone cells can grow to enters the cartilage and are perfectly combined with the artificial cartilage.

Description

technical field [0001] The invention relates to a preparation method of artificial cartilage, which belongs to the field of preparation of medical materials. Background technique [0002] Articular cartilage damage is a common clinical disease in orthopedics. At present, methods for repairing articular cartilage damage include allograft and allograft cartilage transplantation, microfracture technology, artificial joint replacement, tissue engineered cartilage and artificial cartilage materials. The source of donors for allogeneic cartilage transplantation is limited, while allogeneic cartilage transplantation has problems such as immune rejection between donors and recipients. In the past ten years, many scholars have reported that microfracture technology is effective in the treatment of cartilage defects, but there are also disadvantages such as slow repair process, cumbersome rehabilitation program, and fibrocartilage instead of hyaline cartilage. The traditional artifi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/12A61L27/52A61L27/56A61L27/18
Inventor 谢杰胡懿郃苏伟平汪龙李明清雷鹏飞曾敏
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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