A Bone Tissue Gradient Scaffold with Adjustable Degradation Speed ​​and Its Forming Method Based on 3D Printing

Abstract

The invention discloses a bone tissue gradient support with adjustable degradation speed and a forming method based on 3D printing, belonging to the technical field of gradient support. At least one first contact surface and one second contact surface are included to form the closed outer surface of the gradient support; the interior of the gradient support is a porous structure with gradient distribution; the first contact surface is provided with first pores with a diameter less than 100 microns , the second contact surface is provided with a second pore with a diameter of hundreds of microns; the adjacent first pore, the second pore and the internal pore are connected in a non-linear transition manner. The gradient support provided by the invention has a porous structure with gradient distribution, uses TCP mixed photosensitive resin slurry as material, and is formed by DLP photocuring, and the resin is removed during sintering. The nonlinear gradient pores inside the stent can adjust the mechanical properties and degradation rate of the stent on the basis of meeting the pore size requirements on the surface of the stent and the internal pore size, and the degradation process is non-biologically toxic.

Description

technical field [0001] The invention belongs to the technical field of gradient scaffolds, in particular to a bone tissue gradient scaffold with adjustable degradation speed and a forming method based on 3D printing. Background technique [0002] When the bone defect caused by tumor, trauma, infection, etc. exceeds the critical size, the bone tissue will not be able to repair itself, which has become a clinical problem. In traditional treatment methods, for bone defects at or beyond the critical size, metal bone scaffolds or hydroxyapatite scaffolds are usually implanted to bear mechanical loads, but there are still some problems in use, such as scaffold displacement, allergic reactions, Material failure and aging, etc. In addition, since such scaffolds are generally non-degradable, they can only replace bone tissue, but cannot truly repair bone tissue. [0003] With the development of additive manufacturing technology, more and more people are interested in preparing bone...

AI Technical Summary

Problems solved by technology

But so far, the porous structure of ceramic bone scaffolds is relatively simple, mostly one or two pore sizes

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