Degradable polyglycol modified ultra-branching polyether ester and preparation method thereof

A polyethylene glycol modified and hyperbranched polyether technology, which is applied in the field of medical materials, can solve the problems of biocompatibility reduction and achieve the effect of accelerating the degradation rate

Inactive Publication Date: 2008-08-06
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the synthesis of polyethylene glycol PLGA-mPEG copolymer, stannous octoate needs to be used as a catalyst, and this metal ion catalyst is added to reduce the biocompatibility of the product

Method used

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  • Degradable polyglycol modified ultra-branching polyether ester and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] This embodiment 1 is implemented under the following conditions of implementation and technical requirements:

[0023] a In a four-necked flask equipped with an electromagnetic stirrer, a thermometer, a nitrogen inlet and an addition funnel, first pass nitrogen for 30 minutes to remove the air in the reaction system. 7.096g (0.05mol) boron trifluoride ether BF 3 .OEt 2 and 80ml of dichloromethane were added into the flask, and the temperature of the control system was 10°C. Within 5 minutes, 11.62g (0.1mol) of the monomer 3-ethyl-3-butoxanemethanol was slowly added dropwise to the reaction system to maintain The temperature, the reaction 48h. The reaction solution was slowly added dropwise to excess anhydrous diethyl ether, a white precipitate was produced, filtered, washed, and vacuum-dried at 100°C until constant weight. The productive rate of gained hyperbranched product is 92%, and degree of branching is 0.41 (because 13 C-NMR characterizes the degree of branchi...

Embodiment 2

[0026] This embodiment 2 is implemented under the following conditions of implementation and technical requirements:

[0027] a In a four-necked flask equipped with an electromagnetic stirrer, a thermometer, a nitrogen inlet and an addition funnel, first pass nitrogen for 30 minutes to remove the air in the reaction system. Add 7.096g (0.05mol) of boron trifluoride ether BF3.OEt2 and 80ml of chloroform into the flask, control the temperature of the system at 30°C, and within 5 minutes, 11.62g (0.1mol) of monomer 3-ethyl-3 -Butoxanemethanol was slowly added dropwise into the reaction system, and the temperature was maintained for 24 hours of reaction. The reaction solution was slowly added dropwise to excess anhydrous diethyl ether, a white precipitate was produced, filtered, washed, and vacuum-dried at 100°C until constant weight. The yield of the obtained hyperbranched product was 83.5%, and the degree of branching was 0.47.

[0028] b After dissolving the product obtained ...

Embodiment 3

[0030] This embodiment 3 is implemented under the following conditions of implementation and technical requirements:

[0031] a In a four-necked flask equipped with an electromagnetic stirrer, a thermometer, a nitrogen inlet and an addition funnel, first pass nitrogen for 30 minutes to remove the air in the reaction system. Add 7.096g (0.05mol) boron trifluoride ethyl ether BF3.OEt2 and 80ml xylene to the flask, control the system temperature to 70°C, and within 5 minutes, 11.62g (0.1mol) monomer 3-ethyl-3- Butoxymethanol was slowly added dropwise into the reaction system, and the temperature was maintained for 96 hours of reaction. The reaction solution was slowly added dropwise to excess anhydrous diethyl ether, a white precipitate was produced, filtered, washed, and vacuum-dried at 100°C until constant weight. The yield of the obtained hyperbranched product was 94.5%, and the degree of branching was 0.55.

[0032]b Dissolve the product obtained in a with toluene, react 0....

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Abstract

The invention discloses a degradable carbowax modified hyper branched polyester ether and a relative preparation method, belonging to medical material technical field. The preparation method comprises inducing monomer 3-ethyl-3-butoxy heterocyclic carbinol via inducer, processing cation open ring polymerization to obtain hydrophobic hyper branched polyether, adding succinic anhydride, reacting, adding methoxy polyethylene glyol, refluxing and dewatering, to obtain degradable carbowax modified hyper branched polyester ether which is represented as (CH3CH2C(CH2OH)2CH2O)m(CH3CH2C(CH2O)2CH2OH)n(CH3CH2C(CH2O)h(C4H2CH2CH2OCH3)p)I, wherein 0<=m<=20, 0<=n<=40, 0<=h<=40, 0<=i<=40, 6<=p<=85, m+n+h<=50. The invention can meet different biological medical applications, without any catalyst in synthesis and latent toxicity in product.

Description

technical field [0001] The invention relates to a compound in the technical field of medical materials and a preparation method thereof, in particular to a degradable polyethylene glycol modified hyperbranched polyether ester and a preparation method thereof. Background technique [0002] Hyperbranched polymers are a class of polymer materials with excellent properties developed in recent decades, and their research has attracted extensive attention of researchers. Due to the highly branched, three-dimensional spherical molecular structure of hyperbranched polymers, it has many unique properties compared with linear homologues, such as: low viscosity, high solubility, high reactivity and good compatibility, etc. performance. It is particularly important that hyperbranched polymers have a large number of end groups that can be modified. By changing the composition, structure and end group modification of hyperbranched polymers, a variety of new materials that meet special ne...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/91C08G63/66
Inventor 万锕俊寇玉霞张隐西
Owner SHANGHAI JIAO TONG UNIV
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