A biomimetic composite scaffold for simultaneous repair of soft and hard tissue defects and its 3D printing-based molding method

A molding method and 3D printing technology, applied in the field of composite stents, can solve the problems of large bleeding, large surgical wounds, and pronunciation effects, and achieve the effects of repairing soft and hard tissue defects, solving low porosity, and ensuring molding accuracy

Active Publication Date: 2021-12-07
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above palatoplasty can repair the cleft palate to a certain extent, it cannot repair the bone defect of the palate, and the surgical wound is large, the amount of bleeding is large, there are many postoperative complications, and the possibility of infection is high
In addition, the generation of bony scars affects pronunciation

Method used

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  • A biomimetic composite scaffold for simultaneous repair of soft and hard tissue defects and its 3D printing-based molding method
  • A biomimetic composite scaffold for simultaneous repair of soft and hard tissue defects and its 3D printing-based molding method
  • A biomimetic composite scaffold for simultaneous repair of soft and hard tissue defects and its 3D printing-based molding method

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Embodiment Construction

[0034] Reference will now be made in detail to the exemplary embodiments, examples of which are illustrated in the accompanying drawings. In the following descriptions and drawings, unless otherwise indicated, the same numerals in different drawings indicate the same or similar elements. The implementations described in the following exemplary embodiments do not represent all implementations consistent with this application. Rather, they are merely examples of arrangements consistent with aspects of the application as recited in the appended claims.

[0035] It should be noted that all directional indications (such as up, down, left, right, front, back...) in the embodiments of the present application are only used to explain the relationship between the components in a certain posture (as shown in the drawings). Relative positional relationship, movement conditions, etc., if the specific posture changes, the directional indication will also change accordingly.

[0036] In a...

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Abstract

The invention discloses a bionic composite bracket for synchronously repairing soft and hard tissue defects and a forming method based on 3D printing, belonging to the technical field of composite brackets. The biomimetic composite scaffold of the present invention is composed of a first scaffold loaded with fibroblasts and a second scaffold loaded with bone marrow mesenchymal stem cells, and the bone marrow mesenchymal stem cells are filled in the inner pores of the second scaffold; The second bracket is provided with a protruding edge for positioning, the first bracket is located on the upper and lower surfaces of the second bracket, and the first bracket and the second bracket are connected through a dovetail groove. The composite scaffold first uses TCP photosensitive resin mixed slurry to form a ceramic skeleton through DLP photocuring, degreasing and sintering, and then casts GelMA hydrogels loaded with fibroblasts and bone marrow mesenchymal stem cells on the TCP scaffold with the aid of PDMS molds And photocured to form. The bionic composite scaffold proposed by the present invention has biocompatibility and can be used for synchronously repairing soft and hard tissue defects.

Description

technical field [0001] The invention belongs to the technical field of composite brackets, and specifically relates to a bionic composite bracket for synchronously repairing soft and hard tissue defects and a forming method based on 3D printing. Background technique [0002] Cleft lip and palate is a common congenital deformity, and there are about 1.7 cleft lip and palate patients in every 1000 newborns. Cleft lip and palate not only affects the patient's image, but also has negative effects on language learning, dental health, facial development, and mental health. There are many reasons for cleft lip and palate, such as genetic defects, chromosomal variation, and environmental influences, which cannot be completely ruled out through prenatal testing. Generally, cleft lip and palate can be divided into four categories: simple cleft lip, simple cleft palate, unilateral cleft lip combined with cleft palate, and bilateral cleft lip combined with cleft palate, among which sim...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/10A61L27/34A61L27/38A61L27/52A61L27/56B29C33/38B29C33/40
CPCA61L27/12A61L27/52A61L27/34A61L27/3834A61L27/3804B29C33/40B29C33/3842A61L27/10A61L27/56A61L2430/34C08L33/10
Inventor 张斌殷晓红洪忆榕余晓雯李琦
Owner ZHEJIANG UNIV
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