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Multiphase hybrid micro-nano structure magnetic composite material and preparation method thereof

A magnetic composite material and micro-nano structure technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problem of non-uniform dispersion of nanoparticles, achieve excellent biocompatibility, promote adhesion and growth, and have good biological compatibility effect

Inactive Publication Date: 2016-11-09
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The above reports have the following defects: the synthesis of Fe 3 o 4 Or hydroxyapatite nanoparticles are added to the precursor solution, so that the nanoparticles cannot be uniformly dispersed on the scaffold

Method used

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  • Multiphase hybrid micro-nano structure magnetic composite material and preparation method thereof
  • Multiphase hybrid micro-nano structure magnetic composite material and preparation method thereof
  • Multiphase hybrid micro-nano structure magnetic composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Weigh 1.0g of chitosan and dissolve it in 1mL of acetic acid solution with a volume fraction of 1% to obtain an acetic acid solution of chitosan; dissolve 8g of bovine collagen in 8mL of secondary water and stir at room temperature for 2 days to obtain bovine Aqueous solution of collagen;

[0036] (2) Slowly add the dissolved bovine collagen into the chitosan acetic acid solution, stir for 0.5h to make it fully mixed;

[0037] (3) Add 3mL, 2mol / L soluble calcium salt solution and stir for 30min, then add 3mL, 1.2mol / L soluble phosphate solution and stir for 4h;

[0038] (4) According to n(Fe 3+ ):n( Fe 2+ )=2:1 after adding 0.8mol soluble ferrous salt and stirring for 30min, then adding 0.4mol soluble ferrous salt and stirring for 30min;

[0039] (5) Add 5mL, 4mg / mL, EDC and 6.25mL, 1mg / mL, NHS mixed cross-linking agent for cross-linking, cross-linking at room temperature for 4 hours; the final mixture is poured into the mold, moved to 3 ℃ refrigerator for 5 hour...

Embodiment 2

[0049] (1) Weigh 1.3g of chitosan and dissolve it in 1.5mL of acetic acid solution with a volume fraction of 1% to obtain an acetic acid solution of chitosan; dissolve 82g of bovine collagen in 85mL of secondary water and stir at room temperature for 2.5d. Obtain the aqueous solution of bovine collagen;

[0050] (2) Slowly add the dissolved bovine collagen into the chitosan acetic acid solution, stir for 0.5h to make it fully mixed;

[0051] (3) Add 2.4mL, 2.5mol / L soluble calcium salt solution and stir for 30min, then add 2.4mL, 1.5mol / L soluble phosphate solution and stir for 4h;

[0052] (4) According to n(Fe 3+ ): n(Fe 2+ )=1.7:1 ratio, after adding 0.51mol soluble ferrous salt and stirring for 30min, then adding 0.3mol soluble ferrous salt and stirring for 30min;

[0053] (5) Add 6.7mL, 3mg / mL, EDC and 8.3mL, 2mg / mL, NHS mixed cross-linking agent for cross-linking, cross-linking at room temperature for 6h; the final mixture is poured into the mold, and moved to a 3°C r...

Embodiment 3

[0056] (1) Weigh 1.25g of chitosan and dissolve it in 2mL of acetic acid solution with a volume fraction of 1.5% to obtain an acetic acid solution of chitosan; dissolve 9g of bovine collagen in 10mL of secondary water and stir at room temperature for 3 days;

[0057] (2) Slowly add the dissolved bovine collagen into the chitosan acetic acid solution, stir for 0.5h to make it fully mixed;

[0058] (3) Add 2mL, 3mol / L soluble calcium salt solution and stir for 30min, then add 2mL, 1.8mol / L soluble phosphate solution and stir for 4h;

[0059] (4) According to n(Fe 3+ ):n( Fe 2+ )=1.9:1 ratio, after adding 0.76mol soluble ferrous salt and stirring for 30min, then adding 0.4mol soluble ferrous salt and stirring for 30min;

[0060] (5) Add 4.5mL, 0.02g / mL, EDC and 5.6mL, 0.03g / mL, NHS mixed cross-linking agent for cross-linking, cross-linking at room temperature for 4h; the final mixture is poured into the mold, and moved to a 4°C refrigerator for pre-freezing 5h, then freeze at ...

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Abstract

The invention discloses a multiphase hybrid micro-nano structure magnetic composite material. By serving chitosan and bovine collagen as organic matrixes, dissolvable calcium salt and dissolvable phosphate as precursors of inorganic phase nano-hydroxyapatite and serving dissolvable molysite and dissolvable ferrite as precursors of inorganic phase paramagnetic nano ferroferric oxide, the multiphase hybrid micro-nano structure magnetic composite material is prepared through a biological mechanism and an in-situ synthesis preparation technology. Preparation conditions are mild, and the obtained composite material is uniform in pore diameter and good in pore-forming performance, biocompatibility and biodegradability and is expected to become a novel composite material for repairing bone tumors.

Description

technical field [0001] The invention belongs to the field of composite materials, and in particular relates to a multi-phase hybrid micro-nano structure magnetic composite material and a preparation method thereof. Background technique [0002] The incidence of primary bone tumors in my country is about 2 / 100,000 to 3 / 100,000 per year, accounting for 2% to 3% of bone tumors in the whole body, and about 1 / 3 of them are malignant bone tumors. Most primary bone tumors are benign or malignant, but some tumors (such as giant cell tumor of bone and some well-differentiated cartilaginous tumors) show borderline or intermediate features; Tumors are called neoplastic lesions. Some benign bone tumors or tumor-like lesions may have a tendency to become malignant, such as Paget's disease, chondromatosis, and microstructural dysplasia. Bone tumors have the following pathogenic characteristics: 1. Epidemiological characteristics; 2. Age characteristics; 3. Location characteristics; 4. S...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/44A61L27/50A61L27/56A61L27/58
CPCA61L27/46A61L27/446A61L27/50A61L27/56A61L27/58A61L2430/02C08L5/08C08L89/00
Inventor 张其清范田堂胡义敏刘小翠陈景帝
Owner FUZHOU UNIV
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