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Degradable magnesium alloy implanting material for bone fixation and preparing method of degradable magnesium alloy implanting material

An implant material, magnesium alloy technology, applied in the field of biomedical materials, can solve the problems of subcutaneous air bubble body fluid pH value, metal ion concentration change, affecting biocompatibility, etc., achieve degradation rate antibacterial, degradation rate slowdown, degradation rate controllable effect

Active Publication Date: 2016-02-24
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] The magnesium alloys published above have many types of alloying elements, which will inevitably cause changes in the concentration of metal ions in the organism, thereby affecting biocompatibility
Especially the addition of Zn element can effectively improve the strength of the alloy material, but the magnesium alloy with Zn element has poor corrosion resistance in the animal body fluid environment, such as the Mg-Zn alloy with Zn added in the biological fluid environment. Faster corrosion occurs, producing Mg(OH) 2 and H 2 , causing hazards such as subcutaneous air bubbles or increased pH of body fluids
And Zn 2+ The concentration in body fluid should not exceed 170×10 -6 mol / L, compared to Mg 2+ , Ca 2+ 3 orders of magnitude lower in ions that would otherwise be poorly tolerated by cells

Method used

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  • Degradable magnesium alloy implanting material for bone fixation and preparing method of degradable magnesium alloy implanting material
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  • Degradable magnesium alloy implanting material for bone fixation and preparing method of degradable magnesium alloy implanting material

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Embodiment 1

[0080]The magnesium-silver-yttrium alloy composition is set as Mg-0.5%Ag-0.5%Y, and the purity is ≥99.9% metal magnesium ingot, the purity is ≥99.99% metal silver, and the Mg-Y master alloy with a purity ≥99.9% is set as above Alloy composition range batching. Heat the high-purity graphite crucible to 690°C with a resistance furnace, put pure magnesium ingots into the crucible, and add metallic silver after the pure magnesium ingots are melted. After the silver is completely melted, add the Mg-Y master alloy. After the intermediate alloy is completely melted, the melt is stirred for 5 minutes, and argon protection is used during the stirring process to reduce oxidation of the melt. By stirring and standing still, the melt temperature is adjusted to 670° C., and the alloy melt is poured into a preheated steel mold to obtain a Mg-0.5%Ag-0.5%Y alloy ingot.

[0081] After the Mg-0.5%Ag-0.5%Y alloy ingot is cooled in the mold, take it out, place it in the muffle furnace for annea...

Embodiment 2

[0084] The magnesium-silver-yttrium alloy composition is set to be Mg-4%Ag-4%Y, and a metal magnesium ingot with a purity of ≥99.9%, a metal silver with a purity of ≥99.99%, and a Mg-Y master alloy with a purity of ≥99.9% are used according to the above-mentioned setting Alloy composition range batching. Heat the high-purity graphite crucible to 710°C with a resistance furnace, put pure magnesium ingots into the crucible, and add metallic silver after the pure magnesium ingots are melted. After the silver is completely melted, add the Mg-Y master alloy. After the intermediate alloy is completely melted, the melt is stirred for 10 minutes, and argon protection is used during the stirring process to reduce oxidation of the melt. By stirring and standing still, the melt temperature is adjusted to 690° C., and the alloy melt is poured into a preheated steel mold to obtain a Mg-4%Ag-4%Y alloy ingot.

[0085] After the Mg-4%Ag-4%Y alloy ingot is cooled in the mold, take it out, pl...

Embodiment 3

[0091] The composition of the magnesium-silver-yttrium alloy is set to Mg-2%Ag-1%Y, and a metal magnesium ingot with a purity of ≥99.9%, a metal silver with a purity of ≥99.99%, and a Mg-Y master alloy with a purity of ≥99.9% are used according to the above-mentioned setting Alloy composition range batching. Heat the high-purity graphite crucible to 700°C with a resistance furnace, put pure magnesium ingots into the crucible, and add metallic silver after the pure magnesium ingots are melted. After the silver is completely melted, add the Mg-Y master alloy. After the intermediate alloy is completely melted, the melt is stirred for 7 minutes, and argon protection is used during the stirring process to reduce oxidation of the melt. By stirring and standing still, the melt temperature is adjusted to 680° C., and the alloy melt is poured into a preheated steel mold to obtain a Mg-2%Ag-1%Y alloy ingot.

[0092] After the Mg-2%Ag-1%Y alloy ingot is cooled in the mold, take it out,...

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Abstract

The invention relates to a degradable magnesium alloy implanting material for bone fixation and a preparing method of the degradable magnesium alloy implanting material. The implanting material is prepared from, by mass percent, 0.5-4% of Mg, 0.5-4% of Ag and the balance Y. The preparing method of the implanting material comprises the steps of ingot casting metallurgy, extruding, rolling and heat treatment. The prepared implanting material meets the requirement of plates, rods and profiles, wherein the plates, the rods and the profiles serve in biological fluid environments. By means of alloy materials, the good comprehensive mechanical performance needed by bone fixing materials is ensured, the beneficial effects of being capable of inhibiting bacteria, resistant to corrosion, free of cytotoxicity, good in biological mechanical property and the like are achieved, and the alloy materials can be degraded under the biological fluid environments. The implanting material can serve as bone nails or marrow nails or bone fraction plates or other various devices to be used under the medical conditions, and the comprehensive performance is good; and especially, the implanting material has both the biomechanical property and the biodegradable performance at the same time, and the typical defect of existing metal materials of a titanium alloy or stainless steel or high polymer materials in application of the department of orthopaedics is overcome.

Description

technical field [0001] The invention discloses a degradable magnesium alloy implant material for bone fixation and its application and preparation method. In particular, the plate material of the alloy that meets the requirements of serving in a biological fluid environment can be prepared by adopting ingot metallurgy, extrusion and rolling and other methods. , bars and profiles, belonging to the technical field of biomedical materials. Background technique [0002] In recent years, with the rapid development of biomedical implant materials, many new medical implant materials have been successfully applied to clinics and achieved good medical effects. Among them, in orthopedic medical materials, although traditional titanium alloys, stainless steel and other metal materials have been widely used in clinical practice, they also show obvious application limitations. For example, the elastic modulus of titanium alloy is tens of times higher than that of conventional natural bo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C23/00C22C1/03
CPCC22C1/03C22C23/00
Inventor 余琨朱勇戴翌龙龙海涛赵俊孙步华
Owner CENT SOUTH UNIV
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