68results about How to "Reduce calcification" patented technology

The invention relates to a novel percutaneous aortic valve and pulmonary valve exchanger, which is a self-expand support with biological valve, formed by the support in special shape and made from nickel titanium alloy skeleton and the three-blade one-way opening valve formed by pig heart, wherein, the support has fixing and supporting functions, and the pig heart forms three valves fixed in the support. The invention has little hurt, high safety and reduced complication.

Methods for decellularizing mammalian tissue for use in transplantation and tissue engineering. The invention includes methods for simultaneous application of an ionic detergent and a nonionic detergent for a long time period, which may exceed five days. One method utilizes SDS as the ionic detergent and Triton-X 100 as the nonionic detergent. A long rinse step follows, which may also exceed five days in length. This long duration, simultaneous extraction with two detergents produced tissue showing stress-strain curves and DSC data similar to that of fresh, unprocessed tissue. The processed tissue is largely devoid of cells, has the underlying structure essentially intact, and also shows a significantly improved inflammatory response relative to fresh tissue, even without glutaraldehyde fixation. Significantly reduced in situ calcification has also been demonstrated relative to glutaraldehyde fixed tissue. Applicants believe the ionic and non-ionic detergents may act synergistically to bind protein to the ionic detergent and may remove an ionic detergent-protein complex from the tissue using the non-ionic detergent. The present methods find one exemplary use in decellularizing porcine heart valve leaflet and wall tissue for use in transplantation.

The present invention provides for decellularized tissue and method for decellularizing tissue. The method generally comprises the steps of obtaining a harvested tissue, performing a muscle shelf debridement, treating the tissue with an enzyme, washing the tissue with a detergent, and performing an organic solvent extraction on the tissue. The tissues decellularized according to the present invention have several advantages including removing more of the residual cell debris, dsDNA, and chemicals, as well as exhibiting less calcification and better ultimate tensile strength than tissues prepared not according to the method of the present invention.

The invention relates to a natural fluorine-free edible transparent child nutrition toothpaste, belonging to the daily necessities technical field. The natural fluorine-free edible transparent child nutrition toothpaste of the invention is made by adhesive, foaming agent, moisturizer, sweetener, abradant, perfume, deionized water, preservative, hydrolyzed pearl solution, milk calcium, zinc gluconate, vitamin E acetate and vitamin D2 according to the conventional method. The vitamin E acetate, xylitol, hydrolyzed pearl solution, milk calcium, zinc gluoconate and vitamin D2 in the invention act combinedly, oral odour and bacteria can be effectively cleared away, periodontitis and gingivitis can be prevented and treated, caries preventing effect is obvious, and tooth calcification capability can be improved. Nutrition health care function on deciduous teeth of children of two to five can be realized.

The invention discloses a bioprosthetic valve with anticoagulation and anti-calcification functions and a preparation method thereof. The method comprises the following steps: carrying out cross-linking treatment on a biological valve by adopting glutaraldehyde, and carrying out modification treatment by adopting hydrophilic molecules or hydrophobic molecules after cross-linking; or performing modification treatment on the biological valve by hydrophilic molecules or hydrophobic molecules, and then carrying out crosslinking treatment by glutaraldehyde; or performing at least one time of modification treatment on the biological valve by adopting hydrophilic molecules or hydrophobic molecules, then performing cross-linking treatment by glutaraldehyde, and finally performing at least one timeof modification treatment on the biological valve by adopting hydrophilic molecules or hydrophobic molecules. The biological valve prepared by the preparation method disclosed by the invention not only has good mechanical properties, but also has excellent anticoagulation and anti-calcification effects.

The present invention relates to methods and agents for treating impaired vascular and cardiac function. Methods and agents for treating various physiological and pathological features associated with vascular dysfunction and cardiac dysfunction are also provided.

The invention discloses an invisible fish blockage control system based on a network structure. The invisible fish blockage control system comprises a master controller and a plurality of node controllers for controlling fish blockage, wherein the master controller is connected with each node controller through a controller area network (CAN) bus and monitors the operating states of the node controllers; the master controller comprises a master microprocessor, an operation and display processing module and a switching power supply module; the operation and display processing module is connected with the master microprocessor and selects the node controller through the master microprocessor and displays the operating state of the node controller; and the switching power supply module is connected with the master microprocessor, receives the control of the master microprocessor and supplies power to the node controller. According to the control system, multiple fish blockage equipment can be monitored in a unified mode, and the fish blockage out-of-control time is reduced; and moreover, the invisible fish blockage control system has the capacity of automatically adapting to various water areas, good fish blockage effect, long-term free maintenance and the capacity of continuously working all the year round.

The invention discloses a dry artificial biological heart valve containing polypeptide for promoting endothelialization and a preparation method of the dry artificial biological heart valve. The method comprises the following steps that cross-linking is performed on amino groups and carboxyl groups of an animal pericardium, and endothelialization treatment, hydrogel polymerization treatment and dewatering and drying treatment are performed on the animal pericardium, wherein the endothelialization treatment involves that the polypeptide for promoting the endothelialization is adopted to treat the animal pericardium. The preparation method has the advantages that the prepared dry biological heart valve has good water immersion flattening performance, and can be quickly immersed in water andflattened at a higher temperature and higher humidity, thereby reducing residues of glutaraldehyde and the like, and reducing the problems of calcification and toxicity which are caused by the glutaraldehyde and the like, therefore the preoperative installation of a valve system can be simplified, and the additional risks of surgeries are reduced; the polypeptide capable of promoting the endothelialization is also added in the preparation process, so that the prepared biological valve has the property of promoting the endothelialization.

The invention relates to the field of prevention and/or treatment of calcific aortic valvular disease. The inventors research and find that nobiletin can effectively down-regulate expression of osteogenic differentiation marker genes BMP2 and RUNX2 in valvular interstitial cells, and inhibit calcification of the valvular interstitial cells, thereby inhibiting or delaying valvular calcification, and further provide use of the nobiletin in preparing medicines for prevention and/or treatment of individual calcific aortic valvular disease. The invention provides a new option for non-surgical treatment of the calcific aortic valvular disease.

A health-care pillow for hot dressing of cervical vertebrae is composed of a pillow case, a core, and 5 Chinese-medicinal materials including argyi leaf, prickly ash peel, dried ginger, pepper, etc, which are filled in said core. Its application method includes heating the health-care pillow to 40-50 deg.C, and laying the neck on it for 30 min.

The invention relates to the technical field of environment control, in particular to a method for clearing moss in water. The method for clearing the moss in the water comprises the following steps of 1, preparing of drugs: respectively preparing a certain amount of calcium peroxide, chlorine dioxide disinfectant and acetic acid, and crushing the calcium peroxide powder to certain mesh; 2, feeding of drugs: feeding the prepared calcium peroxide into a water body containing the toss, enabling the calcium peroxide to react in water for a period of time, feeding the prepared chlorine dioxide disinfectant, enabling the chlorine dioxide disinfectant to react in water for a period of time, feeding the prepared acetic acid, and enabling the acetic acid to react in water for a period of time, wherein the certain drug feeding frequency is controlled, and the daily feeding frequency is controlled. The method has the advantages that the moss in the water body can be quickly and effectively cleared, the environment-friendly effect is realized, and the operation is easy.

The invention relates to Chinese medicinal decoction used for treating lithiasis and a preparation method thereof, and relates to Chinese medicinal decoction for treating biliary calculus and renal calculus diseases. Main components of the decoction comprise ophiorrhiza pumila, dandelion, rhizoma sparganii, zedoary, white paeony root, herba pyrrosiae, bupleurum, Szechuan lovage rhizome, peach kernel, radix curcumae, gizzard lining, curcuma, knotgrass, gardenia, dried old orange peel, immature tangerine peel, liquorice and the like. The Chinese medicinal decoction can effectively heal intrahepatic bile duct calculus after the gall bladder is extirpated and calcification and sand-like calculus in the kidney, and simultaneously can effectively promote choleresis, improve the self-healing function of the gall bladder, and recover the functions of the gall bladder and the kidney.

The invention belongs to the field of anti-arteriosclerosis drugs, and particularly relates to application of a carbonic anhydrase inhibitor to preparation of the anti-arteriosclerosis drugs. The study finds for the first time that carbonic anhydrase 1 (CA1) is highly expressed in arteriosclerosis calcified tissue, and CA1 is related to vascular smooth muscle calcification and affects cell proliferation and apoptosis. Methazolamide, the inhibitor of CA1, can significantly reduce the progression of atherosclerosis and inhibit atherosclerotic inflammatory factors. The results suggest that calcification plays an important role in atherosclerosis, and CA1-dominated calcification promotes the course of the atherosclerosis. Methazolamide has a potential therapeutic effect on the atherosclerosisby inhibiting expression of CA1. The findings not only further explain the close relationship between the atherosclerosis and the calcification, but also explore the calcification mechanism of the atherosclerosis, and further prove that inhibition of the calcification is a key point in the treatment of the atherosclerosis. The application of the carbonic anhydrase inhibitor to the preparation of the anti-arteriosclerosis drugs provides new ideas for the treatment of the atherosclerosis.

The invention discloses a bio-valve material modified by a zwitterionic polymer and a preparation method thereof, and belongs to the technical field of bio-valve material preparation, the method comprises the following steps: synthesizing a polymer with amino and zwitterions, and connecting the obtained polymer and an acellular bioprosthetic valve to the bio-valve in a chemical bonding manner. The bio-valve material prepared by the invention is a bio-valve material modified by a zwitterionic polymer, and the zwitterionic polymer is added before glutaraldehyde crosslinking or after glutaraldehyde crosslinking. The bio-valve material prepared by the invention not only can solve the problems of calcification and blood coagulation in the existing bio-valve, but also can prolong the service life of the bio-valve.

The present invention discloses a valve with anti-thrombosis and anti-calcification functions, and a preparation method and an application of the valve. The valve comprises a valve base and a zwitterionic copolymer covalently connected to the valve base. During preparation, the valve base is firstly soaked in a glutaraldehyde solution to obtain a cross-linked valve; and then the cross-linked valveis soaked in a zwitterionic polymer solution with a concentration of 0.1-5 wt% for reaction for 2-4 days, and then reduction with a reducing agent is conducted to obtain the valve with the anti-thrombosis and anti-calcification functions. The valve material is subjected to anti-thrombosis and anti-calcification treatments, so that after the valve is implanted in patients, risks of valve leaflet thrombosis can be reduced, valve leaflet thickening and transvalvular differential pressure increase are prevented, a long-term hydrodynamic performance is improved, patients can avoid or reduce uses of anticoagulant and antiplatelet drugs, risks of patient bleeding are reduced, besides, aldehyde residues in the valve leaflet tissues are reduced, biocompatibility and anti-calcification ability areimproved, and ultimately complications of valve leaflet thrombosis are reduced and service life of the valve is extended.

The present invention relates to a method for treating biological tissue and a biological tissue obtained by the treatment method, and specifically to a method for treating biological tissue so as to suppress the calcification, risk of biofilm adherent over pericardium and strength reduction of the tissue due to treatment. The invention is also directed to bioprosthesis and transcatheter heart valves containing the biological tissue.