9results about How to "Reduce calcification" patented technology

The invention discloses a drug-loaded nanogel modified bioprosthetic valve as well as a preparation method and application thereof, and belongs to the technical field of preparation of medical materials and medical instruments. The preparation method comprises the following steps: firstly, synthesizing an active oxygen response monomer by taking thioketal-containing methacrylate and methylprednisone hemisuccinate as raw materials, then synthesizing active oxygen response type drug-loaded nanogel, and then introducing the active oxygen response type drug-loaded nanogel to the surface of the bioprosthetic valve through chemical bonding; in a pathological environment with relatively high active oxygen concentration, a thioketal group in the monomer is decomposed, and methylprednisone hemisuccinate is released at a fixed point, so that inflammatory cell infiltration is reduced, and the anti-inflammatory performance of the bioprosthetic valve is improved; in addition, the nanogel contains a large number of hydrophilic groups, a hydration layer is formed on the surface of the bioprosthetic valve, and the risk of thrombus and blood coagulation can be effectively reduced; the prepared bioprosthetic valve has excellent anti-inflammatory, anti-coagulation and anti-calcification capabilities and stability.

The present disclosure relates to a medical device comprising a specially heat treated component and a method of heat treating a metal alloy for the medical device.

The application belongs to the field of biological medicine, and particularly relates to application of acetaldehyde dehydrogenase 2 (ALDH2) in preparation of a drug for treating vascular calcification. The application provides application of ALDH2 or an inducing agent thereof in preparation of a drug for treating vascular calcification. Through research on ALDH2, the application finds that ALDH2 can regulate vascular smooth muscle cells (VSMCs) in various vascular related diseases, and further finds a new mechanism that ALDH2 reduces transformation of VSMCs from a contraction type to a synthesis type and delays progress of vascular calcification. The application provides a new target for prevention and treatment of vascular calcification, and activation of ALDH2 is expected to be a potential intervention means for vascular calcification. A drug with ALDH2 as an active ingredient is a potential new type of therapeutic reagent for vascular calcification.

The present invention discloses a biological valve modified by a drug-loaded nanogel and a preparation method and application thereof, and belongs to the technical field of medical materials and medical device preparation. The present invention first uses thioketal-containing methacrylate and methylprednisolone hemisuccinate as raw materials to synthesize an active oxygen responsive monomer, then synthesizes an active oxygen responsive drug-loaded nanogel, and then introduces the active oxygen responsive drug-loaded nanogel to the surface of the biological valve by chemical bonding; under a pathological environment with a high concentration of active oxygen, the thioketal group in the monomer decomposes, and methylprednisolone hemisuccinate is released at a fixed point, thereby reducing inflammatory cell infiltration and improving the anti-inflammatory performance of the biological valve; in addition, the nanogel contains a large number of hydrophilic groups, forming a hydration layer on the surface of the biological valve, which can effectively reduce the risk of thrombosis and coagulation; the prepared biological valve has excellent anti-inflammatory, anti-coagulation, anti-calcification ability and stability.

This invention discloses an esterase-responsive nanogel-modified bioprosthetic valve, its preparation method, and its application, belonging to the field of bioprosthetic valve technology. This invention solves the problem of balancing the anti-infective properties, biocompatibility, and high surface modification rate of bioprosthetic valves. The invention uses ester-containing methacrylates and antibiotic drugs as raw materials to synthesize esterase-responsive monomers, then synthesizes esterase-responsive nanogels, and then attaches them to the surface of the bioprosthetic valve. Under pathological conditions with high esterase concentrations, the ester bonds decompose, releasing the antibiotic drugs in situ, thereby treating bacterial infections, reducing inflammatory cell infiltration, and improving the anti-infective and anti-inflammatory properties of the bioprosthetic valve. Furthermore, the nanogel contains a large number of hydrophilic groups, forming a hydration layer on the bioprosthetic valve surface, effectively reducing the risk of thrombosis and coagulation, and resisting bacterial adhesion. The prepared bioprosthetic valve exhibits excellent anti-infective, anticoagulant, anti-calcification capabilities and stability.

The invention relates to a faucet for an aircraft cabin, a lavatory, a lavatory unit and an aircraft cabin, an aircraft and a method for providing water from a faucet. The faucet includes at least one water inlet, a pressure regulator, a discharge arrangement and a manual interaction element. The at least one water inlet is configured to provide a water supply and is in fluid connection with the discharge arrangement via the pressure regulator, thereby forming a flow path from the water inlet to the discharge arrangement. The pressure regulator is configured to regulate a variable inlet pressure of the water supply source to a corrected pressure of the water supply source to the discharge arrangement. The faucet also includes a vent valve fluidly connected to the flow path and configured to allow gas exchange and close when water inside the flow path reaches the vent valve. Based on the corrected pressure, the discharge arrangement is configured to provide a predetermined amount of water to the user when the manual interaction element is enabled.

The invention provides a preparation method of a biological tissue material, which comprises the following steps: c, carrying out functional modification on a pretreated tissue, namely oxidizing groups on the pretreated tissue and grafting anti-inflammatory and anticoagulant functional groups. The invention also provides the biological tissue material prepared by the preparation method. The service life of the xenograft is prolonged by introducing anticoagulant functional molecules on the basis of non-aldehyde tissue fixation and antigen content reduction, the technical problem that an existing xenograft tissue material is high in antigen content is solved, and the problems of aldehyde group residue, depolymerization and the like caused by glutaraldehyde fixation can be effectively avoided; inflammation, thrombus and easy calcification caused by implantation are effectively improved through functional modification; and the technical problems of immune response of implanted biological tissue materials and the like are also solved.

This invention relates to the field of biopharmaceutical technology, and in particular to an antibody-targeted modified dual-strain prebiotic delivery system, its preparation method, and its applications. This invention modifies VCAM-1 antibody fragments onto *AKK* bacteria and *Bifidobacterium lactis* Probio-M8, then utilizes fructooligosaccharides and inulin as prebiotics to enhance probiotic metabolism and promote intestinal colonization. Finally, it coats the system with hydroxypropyl methylcellulose phthalate (HPMCP) enteric coating to construct the antibody-targeted modified dual-strain prebiotic delivery system—V-PM8-Am-FI-HPMC. The V-PM8-Am-FI-HPMC provided by this invention can simultaneously achieve intestinal flora regulation, lipid metabolism balance, inflammation suppression, ischemia improvement, and vascular anti-calcification, ultimately achieving the purpose of treating and / or improving atherosclerosis, while ensuring targeting and safety.

The present invention discloses a biovalve modifier and a polymer-modified biovalve and a preparation method, and belongs to the technical field of medical material and medical device preparation. The biovalve modifier is formed by polymerization of a diclofenac monomer containing a thioketal group, a hydrophilic monomer, a crosslinking agent, an active ester monomer and an initiator. The preparation method of the polymer-modified biovalve comprises the following steps: sequentially immersing the biovalve material in a glutaraldehyde solution, an amino cationic polymer solution, and a nanogel solution, and finally immersing the biovalve twice in an active ester compound solution. The polymer-modified biovalve prepared by the present invention is a biovalve in which nanogels are modified on the valve surface by covalent bonds, has good stability and long-term effect, and has good biocompatibility and anti-inflammatory, anticoagulant and anti-calcification effects, and has good medical application prospects.