4results about How to "Reduce calcification" patented technology

The application belongs to the field of biological medicine, and particularly relates to application of acetaldehyde dehydrogenase 2 (ALDH2) in preparation of a drug for treating vascular calcification. The application provides application of ALDH2 or an inducing agent thereof in preparation of a drug for treating vascular calcification. Through research on ALDH2, the application finds that ALDH2 can regulate vascular smooth muscle cells (VSMCs) in various vascular related diseases, and further finds a new mechanism that ALDH2 reduces transformation of VSMCs from a contraction type to a synthesis type and delays progress of vascular calcification. The application provides a new target for prevention and treatment of vascular calcification, and activation of ALDH2 is expected to be a potential intervention means for vascular calcification. A drug with ALDH2 as an active ingredient is a potential new type of therapeutic reagent for vascular calcification.

This invention discloses an esterase-responsive nanogel-modified bioprosthetic valve, its preparation method, and its application, belonging to the field of bioprosthetic valve technology. This invention solves the problem of balancing the anti-infective properties, biocompatibility, and high surface modification rate of bioprosthetic valves. The invention uses ester-containing methacrylates and antibiotic drugs as raw materials to synthesize esterase-responsive monomers, then synthesizes esterase-responsive nanogels, and then attaches them to the surface of the bioprosthetic valve. Under pathological conditions with high esterase concentrations, the ester bonds decompose, releasing the antibiotic drugs in situ, thereby treating bacterial infections, reducing inflammatory cell infiltration, and improving the anti-infective and anti-inflammatory properties of the bioprosthetic valve. Furthermore, the nanogel contains a large number of hydrophilic groups, forming a hydration layer on the bioprosthetic valve surface, effectively reducing the risk of thrombosis and coagulation, and resisting bacterial adhesion. The prepared bioprosthetic valve exhibits excellent anti-infective, anticoagulant, anti-calcification capabilities and stability.

The invention relates to a faucet for an aircraft cabin, a lavatory, a lavatory unit and an aircraft cabin, an aircraft and a method for providing water from a faucet. The faucet includes at least one water inlet, a pressure regulator, a discharge arrangement and a manual interaction element. The at least one water inlet is configured to provide a water supply and is in fluid connection with the discharge arrangement via the pressure regulator, thereby forming a flow path from the water inlet to the discharge arrangement. The pressure regulator is configured to regulate a variable inlet pressure of the water supply source to a corrected pressure of the water supply source to the discharge arrangement. The faucet also includes a vent valve fluidly connected to the flow path and configured to allow gas exchange and close when water inside the flow path reaches the vent valve. Based on the corrected pressure, the discharge arrangement is configured to provide a predetermined amount of water to the user when the manual interaction element is enabled.

This invention relates to the field of biopharmaceutical technology, and in particular to an antibody-targeted modified dual-strain prebiotic delivery system, its preparation method, and its applications. This invention modifies VCAM-1 antibody fragments onto *AKK* bacteria and *Bifidobacterium lactis* Probio-M8, then utilizes fructooligosaccharides and inulin as prebiotics to enhance probiotic metabolism and promote intestinal colonization. Finally, it coats the system with hydroxypropyl methylcellulose phthalate (HPMCP) enteric coating to construct the antibody-targeted modified dual-strain prebiotic delivery system—V-PM8-Am-FI-HPMC. The V-PM8-Am-FI-HPMC provided by this invention can simultaneously achieve intestinal flora regulation, lipid metabolism balance, inflammation suppression, ischemia improvement, and vascular anti-calcification, ultimately achieving the purpose of treating and / or improving atherosclerosis, while ensuring targeting and safety.