Bio-valve material modified by zwitterionic polymer and preparation method thereof

A zwitterion, biological valve technology, used in drug delivery, tissue regeneration, pharmaceutical formulations, etc., to reduce biological toxicity problems, reduce coagulation risks, and reduce calcification problems.
CN113082292AInactive Publication Date: 2021-07-09WEST CHINA HOSPITAL SICHUAN UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
WEST CHINA HOSPITAL SICHUAN UNIV
Publication Date
2021-07-09
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention discloses a bio-valve material modified by a zwitterionic polymer and a preparation method thereof, and belongs to the technical field of bio-valve material preparation, the method comprises the following steps: synthesizing a polymer with amino and zwitterions, and connecting the obtained polymer and an acellular bioprosthetic valve to the bio-valve in a chemical bonding manner. The bio-valve material prepared by the invention is a bio-valve material modified by a zwitterionic polymer, and the zwitterionic polymer is added before glutaraldehyde crosslinking or after glutaraldehyde crosslinking. The bio-valve material prepared by the invention not only can solve the problems of calcification and blood coagulation in the existing bio-valve, but also can prolong the service life of the bio-valve.
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Description

technical field

[0001] The invention relates to the technical field of biological valve material preparation, in particular to a zwitterionic polymer modified biological valve material and a preparation method thereof. Background technique

[0002] Traditional surgical thoracotomy is an important way to treat valvular diseases, but it has high surgical risks, large trauma, and long recovery time for patients. In recent years, transcatheter minimally invasive interventional replacement of diseased heart valves has become the main treatment for valve diseases. However, minimally invasive interventional valve replacement surgery often uses glutaraldehyde-crosslinked biological valves as valve leaflets, which are prone to calcification and coagulation problems, and pure glutaraldehyde-crosslinked biological valves have poor durability and need to be implanted after a certain number of years. Replace again. Therefore, how to further modify the glutaraldehyde-crosslinked biologi...

Claims

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