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Medicine composition of safflower and rhodiola root

A composition, technology of Rhodiola rosea, used in the field of medicine

Inactive Publication Date: 2007-03-21
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of safflower or safflower yellow pigment and Rhodiola rosea interaction, compatibility prescriptions, preparation of drugs for the treatment of cardiovascular and cerebrovascular diseases, has not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0155] Embodiment 1 Preparation one of safflower yellow pigment

[0156] Take the safflower, and soak it with acid water with a pH of 3 for 2 to 4 times at a temperature of 70°C, each time with 50 times the amount of acid water, and each time for 1.5 hours. Combine the extracts, filter, collect the filtrate, let it cool, adjust the pH value to neutral, concentrate under reduced pressure to a relative density of 1.05-1.10, add ethanol until the alcohol concentration is 70%, refrigerate (below 10°C) for 24 hours, filter After that, the filtrate is added to the processed macroporous adsorption resin HPD100 column chromatography (the ratio of medicinal material and resin is 1:10 (W / V)), and the deionized water is used to deionize the water with 1~2.5ml / cm 2 / min flow rate to elute two column bed volumes, and then use 60% ethanol at 1-2.5ml / cm 2 5 column bed volumes were eluted at a flow rate of 60% / min, and the eluted part with 60% alcohol was collected, concentrated under reduce...

Embodiment 2

[0165] Embodiment 2 The preparation of safflower yellow pigment two

[0166] Take 250 kg of safflower, add water and decoct for 1.5 hours, filter, concentrate the filtrate to a relative density of 1.14, add ethanol to the concentrated solution to an alcohol content of 80%, and keep stirring, precipitate at 4°C for 24 hours, filter, recover the ethanol from the filtrate and Concentrate until the relative density is 1.18, add 8 times of water, precipitate at 4°C for 24 hours, centrifuge to remove the precipitate, concentrate under reduced pressure until the extract contains crude drug 1g / ml, and pass the concentrated solution through macroporous adsorption resin column chromatography. Elute with deionized water until the Molish reaction and ninhydrin reaction are negative, continue to elute with 6 column volumes of deionized water and collect the eluate, concentrate until the extract contains 1g / ml crude drug, and put it on a polyamide column. First eluted with deionized water u...

Embodiment 3

[0172] The preparation of embodiment 3 rhodiola rosea total phenols

[0173] Take 200 kg of Rhodiola rosea medicinal material, crush it into a coarse powder, extract three times with 70% ethanol for 1 hour each time, add 10 times the amount of alcohol for the first time, and add 8 times and 8 times the amount for the second and third times respectively. Filtrate, combine the extracts, recover ethanol until every 5ml contains 1g raw medicinal materials, degrease with 2 times the amount of petroleum ether, discard the petroleum ether liquid, then extract with n-butanol saturated with water, concentrate under reduced pressure to a thick paste, spray After drying, the crude extract of Rhodiola rosea is obtained.

[0174] After dissolving 10.05 kg of Rhodiola rosea crude extract with an appropriate amount of water, add it to a macroporous resin column that has been treated in advance, and then elute with water solution, 10% ethanol, 15% ethanol, 20% ethanol, and 30% ethanol, The e...

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Abstract

The present invention belongs to the field of medicine technology, and is especially one kind of medicine composition for treating cardiac and cerebral vascular diseases and its preparation process. The medicine composition is prepared with safflower 500-10000 weight portions and rhodiola root 250-3000 weight portions; or prepared with safflower yellow pigment 50 weight portions and rhodiola root extract. The medicine composition may be prepared into different pharmaceutically acceptable forms, preferably injection and orally taken preparation. The medicine composition is used in treating coronary heart disease, angina pecoris, myocardial infaction, ischemic cerebral vascular diseases, etc.

Description

[technical field] [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. [Background technique] [0002] As our country gradually enters into an aging society, people's living standards are improving, the pace of life is accelerating, and eating habits are developing towards high fever and high fat. Cardiovascular and cerebrovascular diseases have become the number one killer that threatens human health and longevity. According to relevant statistics in recent years, people who die from cardiovascular and cerebrovascular diseases account for about half of the cause of death in my country every year. Its morbidity rate is high, harmfulness is big, and the mortality rate and disability rate after the onset are quite high, bring trouble and burden to patient and family. Therefore, to reveal the mechanism of the occurrenc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/41A61P9/10A61K31/352
Inventor 蔡军
Owner 海安江理工技术转移中心有限公司
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