Static spraying composite film and preparation method and application thereof

A composite film and electrostatic spraying technology, applied in the field of materials, can solve the problems of waste of cotton yarn resources, easy drying of dressings, pain of patients, etc., and achieve the effects of promoting wound healing, increasing flexibility, and wide-ranging antibacterial properties.

Active Publication Date: 2016-08-31
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, traditional gauze dressings are widely used in various medical institutions in our country. This dressing is easy to dry out and needs to be replaced frequently, which wastes a lot of cotton yarn resources and brings pain to patients.

Method used

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  • Static spraying composite film and preparation method and application thereof
  • Static spraying composite film and preparation method and application thereof
  • Static spraying composite film and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] (1) Dissolve PVDF powder in acetone / dimethylacetamide DMAC (the ratio of acetone and DMAC is 1:1 by mass) mixed solvent, and prepare the mass fractions of 6%, 8%, 10%, and 12% respectively , 14% spinning solution. At room temperature, the solution was airtightly stirred on a magnetic stirrer for 6 hours, ultrasonic (power 120W, frequency 40,000Hz,) 2 hours, to ensure that the polymer was completely dissolved, and a homogeneous solution was obtained. Spinning: 10ml PVDF spinning liquid is spun at 15KV, receiving distance 15cm, using aluminum foil as receiving medium, and the flow rate is 0.5mL / h;

[0072] (2) The electrospun membrane was vacuum filtered and dried (drying pressure 10mpa, drying temperature 45°C, drying time 24h), to remove residual organic solvents, vacuum filtered and dried, and then analyzed by scanning electron microscope, the results were as follows figure 1 shown.

[0073] figure 1 SEM images and diameter distribution images of nanofibers prepared...

Embodiment 2

[0075] (1) PLA particles were dissolved in chloroform to form spinning solutions with a mass fraction of 1%, 3%, and 5%, respectively, and Cur was added to the PLA spinning solution to prepare a mass ratio of PLA to Cur of 85 / 15. At room temperature, the solution was airtightly stirred on a magnetic stirrer for 6 hours, and ultrasonic (power 120W, frequency 40,000Hz) was used for 2 hours to ensure that the PLA polymer and drug were completely dissolved to obtain a transparent solution. for subsequent spinning. 10ml of Cur-PLA spinning solution was prepared under the conditions of 17KV, receiving distance of 15cm, and flow rate of 0.5mL / h.

[0076] (2) The electrospun membrane was vacuum filtered and dried (drying pressure 10mpa, drying temperature 45°C, drying time 24h), to remove residual organic solvents, vacuum filtered and dried, and then analyzed by scanning electron microscope, the results were as follows figure 2 shown.

[0077] figure 2 For the same solvent (chlor...

Embodiment 3

[0079] PLA particles were dissolved in acetone / DMAC (1:1, m / m) mixed solvent to prepare electrospinning solutions with mass fractions of 6%, 10%, 14%, and 16%, respectively. Add enrofloxacin solid drug into the PLA spinning solution to prepare the mass ratio of Enro to PLA as 20 / 80. At room temperature, the solution was airtightly stirred on a magnetic stirrer for 6 hours, and ultrasonic (power 120W, frequency 40,000Hz) was used for 2 hours to ensure that the PLA polymer and drug were completely dissolved to obtain a transparent solution. for subsequent spinning. 10ml of spinning dope was prepared under the conditions of a unified electrospinning process with a spinning voltage of 15KV, a receiving distance of 10cm, and a flow rate of 0.5mL / h.

[0080] The electrospun membrane was vacuum-filtered and dried (drying pressure 10mpa, drying temperature 45°C, drying time 24h) to remove residual organic solvents. After vacuum-filtering and drying, the morphology was analyzed with a...

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Abstract

The invention discloses a static spraying composite film and a preparation method and application thereof. A PVDF nanofiber thin film is spun on a roller receiver through electrostatic spinning to serve as a supporting material, then a layer of Cur-PLA microspheres is sprayed through an electrostatic spraying method, and a double-layer film is obtained; an Enro-PLA nanofiber film is spun on the double-layer film through an electrostatic spinning method, drying is carried out, and the electrostatic spraying composite film is obtained. Medicine is carried on polylactic acid fibers and the microspheres, so that the biological activity and antibacterial property of the electrospinning film are achieved; compared with like products, a hydrophilic face formed by the PLA microspheres and the PLA fibers is not single in medicine release capacity, wider in antibacterial performance and larger in contact area with the skin surface. PVDF is adopted as an outer layer for isolating invasion of water vapor and bacteria. The preparation method is simple, the production cost is low, large-scale production can be achieved, application and popularization are convenient, and the final product can completely meet various clinical needs.

Description

technical field [0001] The invention belongs to the field of materials, and in particular relates to an electrostatic spray composite film and its preparation method and application. Background technique [0002] At present, traditional gauze dressings are also widely used in various medical institutions in my country. This dressing is easy to dry out and needs to be replaced frequently, which wastes a lot of cotton yarn resources and brings pain to patients. Therefore, increasing the research and development of functional dressings with high technical content to improve the therapeutic effect, accelerate wound healing, and reduce the environmental pollution of discarded dressings has become an urgent task for scientific researchers. Contents of the invention [0003] The primary purpose of the present invention is to overcome the shortcomings and deficiencies of the prior art, and provide a method for preparing an electrostatically sprayed composite film. [0004] Anothe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/4318D04H1/435D04H1/728D01D5/00A61L15/24A61L15/26A61L15/44A61L15/64
CPCA61L15/24A61L15/26A61L15/44A61L15/64A61L2300/404A61L2300/41A61L2300/412A61L2300/602A61L2300/604D01D5/003D01D5/0092D04H1/4318D04H1/435D04H1/728C08L27/16C08L67/04
Inventor 周武艺李锦珍何婷董先明刘威
Owner SOUTH CHINA AGRI UNIV
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