67results about How to "Meet the requirements of clinical use" patented technology

The present invention relates to an SNP (single nucleotide polymorphism) combination, detection method and kit for detecting liver damage susceptible genotype of an antitubercular drug and belongs to the technical field of medical molecular biological diagnosis; the SNP combination includes 7 SNP sites, and nucleotide sequences of the 7 SNP sites are shown sequentially as in SEQ ID NO. 1-7; the present invention also relates to an SNP detection method, comprising PCR (polymerase chain reaction) amplification and double-labeled probe melting curve analytical reaction, and primer pairs and double-labeled probe sequences for detection of the 7 SNP sites are shown as in SEQ ID NO. 8-20. The SNP site combination, detection method and kit provided herein enables quick, accurate, simple and high-throughput detection for a patient's genotype and prediction for the liver damage risk due to the patient using the antitubercular drug.

The invention relates to a disposable high speed turbine dental drill handpiece with a light producing device which is characterized in that a place of a front operating handle close to a handpiece isconnected with a lamp socket for installing a light-emitting diode, the head of the light-emitting diode is exposed from a hole of the lamp socket and opposites to a cutting position of a dill point,two electrodes at the tail part of the light-emitting diode are respectively connected with two light-emitting diode lead wires; a rear operation handle is provided with a battery bin which is provided with a battery bin cover, a space containing a illuminating gas switch is arranged below the battery bin, the bottom of the space is communicated with an air passage of the illuminating gas switchin the rear operating handle, the air passage of the illuminating gas switch is parallel to the air passage of a driving drill point and the two air passages are both communicated with a gas pipelineat the tail part of the rear operating handle, a button battery is put in the battery bin, the positive pole of the button battery is communicated with a lead wire of the light-emitting diode, and thenegative pole of the button battery is connected with the other lead wire of the light-emitting diode by the illuminating gas switch. The dental drill handpiece is characterized by low cost, safe andconvenient use, and good illuminating effect, and is applicable to be arranged in various dental units.

The invention relates to a preparation method for an antibacterial liquid-absorbing gauze, which belongs to the field of preparation of medical dressings. According to the invention, a quaternary ammonium salt group is introduced onto a cellulose molecular chain of a degreased gauze through an epoxide ring-opening or nucleophilic substitution reaction, so polycation characteristics of cellulose of the gauze are increased, and antibacterial properties of the gauze are improved; through controlling of a mol ratio of a hydroxyl group to a quaternary ammonium salt on the cellulose molecular chain of the degreased gauze and reaction conditions, the degree of substitution of the quaternary ammonium salt on the cellulose molecular chain is in a range of 5 to 80%, so the reacted gauze has high antibacterial properties and high liquid absorption performance and can maintain the basic form of yarns after absorption of liquid. The antibacterial liquid-absorbing gauze prepared by using the preparation method provided by the invention overcomes the defect of a single function of a conventional medical gauze, is applicable to an infectious wound with a great amount of exudate or an infectible wound and exerts the effects of killing of bacteria on the surface of the wound and absorption of exudate on the surface of the wound. The preparation method for the antibacterial liquid-absorbing gauze has the advantages of easiness, low cost and easy industrial production.

The invention discloses a medicine box for preparing technetium-99m (99mTc) labeled DTPA-LSA (99mTc-DTPA-LSA), a preparation method and application thereof. The medicine box is prepared by the method as follows: dissolving DTPA-LSA ligand in nitrogen-filled secondary water; adding buffer solution; mixing well; adding a reducing agent in a weight ratio of the reducing agent to the ligand of 1:10-800; performing sterile filtration on solution after dissolution is completely over; and putting the obtained product into containers separately. In the aspect of preparing 99mTc-DTPA-LSA, the medicine box has the advantages of use convenience, high labeling rate, good biological properties of prepared 99mTc-DTPA-LSA, low use cost and the like, and is beneficial to extensive clinical application. 99mTc-DTPA-LSA complex prepared by utilizing the medicine box can be sued as a novel liver imaging agent applied in the technical fields of radiopharmaceutical chemistry and clinical nuclear medicine.

Disclosed are a degradable zinc alloy peritoneoscope hemostatic clip and a preparing method thereof. The degradable zinc alloy peritoneoscope hemostatic clip is made of a zinc alloy. As for the components of the zinc alloy, an alloy element Mg is added into a pure zinc matrix. The degradable zinc alloy peritoneoscope hemostatic clip has the advantages that by introducing an arc structure and additionally arranging a lock catch, anti-slide insections and a limiting protrusion, stress concentration after the metal hemostatic clip is closed is effectively improved, meanwhile the clamping propertyof the hemostatic clip is effectively improved, and the risk of sliding off of the hemostatic clip after an operation is reduced; zinc is a necessary element of the human body, the good biocompatibility and absorbability are achieved by using the hemostatic clip prepared through the zinc alloy, and meanwhile, the service time of the hemostatic clip is increased obviously through the appropriate degradation in vivo characteristic of the hemostatic clip; the hemostatic clip is simple and easy in structure and simple in preparation technology, and the preparation cost is reduced effectively; andthe designed and prepared hemostatic clip fully meets the clinical use requirement.

The invention provides a stable rosuvastatin calcium pharmaceutical composition. The composition has high stability. A tablet containing the pharmaceutical composition has total impurity content of lower than 1.0% after accelerated testing, wherein lactone individual impurity content is lower than 0.10%.

Provided are a bone repair material and a preparation and use method thereof. The bone repair material is composed of a strontium compound and alpha-calcium sulfate hemihydrate. The molar weight of strontium occupies 0.1-10% of the total molar weight of calcium and the strontium. The preparation method includes 1) utilizing a co-precipitation method to prepare strontium CaSO4.2H2O and 2) utilizing a hydrothermal method to prepare strontium CaSO4.0.5H2O. Compared with the prior art, the bone repair material has the advantage that the bone repair material can serve as a bone filling material which is better in quality, degradable and good in bioactivity, can promote bone repair and can serve as an application of a drug delivery system.

A powder injection of compound diisopropylamine dichloroacetate is prepared from diisopropylamine dichloroacetate, sodium gluconate, mannitol and the water for injection through dissolving sodium gluconate in the water for injection, adding acetic acid to regulate pH-4.0-6.5, adding others, stirring and freeze drying.

The invention relates to an absorbable iron-based instrument which comprises an iron-based matrix, a zinc-containing protective layer, a corrosion promoting layer and a drug controlled release layer, the iron-based matrix is provided with an outer wall, an inner wall and a side wall, the zinc-containing protective layer at least covers the outer wall and the inner wall of the iron-based matrix, the corrosion promoting layer completely covers the zinc-containing protective layer, the drug controlled release layer at least partially covers the corrosion promoting layer, both the corrosion promoting layer and the drug controlled release layer contain degradable polymers, the weight-average molecular weight of the degradable polymer in the corrosion promoting layer is greater than that of the degradable polymer in the drug controlled release layer, and a thickness ratio of a portion of the zinc-containing protective layer located on the inner wall to a portion of the corrosion promoting layer located on the inner wall is greater than a thickness ratio of a portion of the zinc-containing protective layer located on the outer wall to a portion of the corrosion promoting layer located on the outer wall. The corrosion behavior of the absorbable iron-based instrument meets the clinical use requirement, and the adverse histological reaction is less or not generated.

The invention relates to a valsartan capsule and a preparation method thereof. The valsartan capsule comprises an active component valsartan and hydroxypropylcellulose serving as a disintegrating agent and an adhesive. The preparation method of the valsartan capsule comprises the following steps that 1), valsartan is sieved by a 200-mesh sieve; a filling agent and hydroxypropylcellulose are sieved by an 80-mesh sieve, and mixed uniformly; 2), an alcohol solution with the concentration of 5-60% is prepared, and accounts for 45-55% of the gross weight of valsartan, hydroxypropylcellulose, the filling agent, a cosolvent and a lubricant, and the cosolvent is dissolved by a half of the alcohol solution; 3), valsartan premix powder is placed in a wet method granulator, the alcohol solution of the cosolvent is added, and the left alcohol solution and purified water are added according to a granulation situation of a material, and stirred to form wet particles sieved by a 14-mesh sieve; 4), the wet particles are dried and granulated; and 5), the particles are uniformly mixed with the lubricant sieved by the 80-mesh sieve and filled to form the valsartan capsule. The valsartan capsule can be disintegrated and dissolved out quickly, and is simple in technology and stable in quality.

The invention discloses a method for preparing a high-strength hydroxylapatite and chitosan three-dimensional composite rod material, which comprises the following steps: adding a calcium salt and a phosphate into solution of acetic acid to form solution of a hydroxylapatite precursor; dissolving chitosan powder in the solution of the precursor and standing the solution for deaeration; filling the mixed solution in a mold and obtaining a hydroxylapatite and chitosan three-dimensional composite gel rod material through the pervasion of alkaline coagulating liquid and self-assembly; and placing the hydroxylapatite and chitosan three-dimensional composite gel rod material in aqueous solution of glutaraldehyde and standing the solution for crosslinking, soaking and washing the resulting product with deionized water and drying the resulting product. The bending strength and bending modulus of the hydroxylapatite and chitosan three-dimensional composite gel rod material can reach 178MPa and 5.2GPa respectively, so the hydroxylapatite and chitosan three-dimensional composite gel rod material can meet clinic use requirements for fracture internal fixation.

The invention relates to a method for in vitro amplification of hemopoietic stem cells. The method comprises the steps of separation of mononuclear cells, preparation and culture of microencapsulated mononuclear cells and amplification of hemopoietic stem cells. The method can realize the effective amplification of hemopoietic stem cell as well as carries out culture on a large scale, thereby stimulating the development of blood biology and clinic application and research.

The invention discloses a plate rod snap ring for a removable partial denture. According to the plate rod snap ring, the bottom of a U-shaped minor connector is connected with a connector; one end of the top of the U-shaped minor connector is connected with an occlusal rest on the mesial side of an oeclusal of an abutment, and the other end of the top of the U-shaped minor connector is connected with a distal adjacent panel; the distal adjacent panel is attached to a guide plane prepared from distal adjacent surfaces of the abutment; the cheek side upper end of the distal adjacent panel is connected with a retention arm; and the tail of the retention arm is clamped in an inverted concave area of the cheek side of the abutment and does not exceed a cheek axial ridge of the abutment. The plate rod snap ring for the removable partial denture does not influence the face and attractiveness of the patient, does not disturb the arrangement of artificial teeth and has a wide application range.

The invention relates to a medicinal preparation containing Candida urate oxidase, in particular to a liquid or freeze-dried composition medicinal preparation containing the Candida urate oxidase. The composition comprises the following active ingredients: the Candida urate oxidase, glycine, cysteine and a buffer system. The composition is aseptic, and can be injected into human body or animal body to take effect through hypodermic injection, intravenous injection or intramuscular injection.

Calcium nitrate, diammonium phosphate and urea are mixed and added with strontium phosphate to be mixed, stirred and heated, to prepare strontium containing hydroxyapatite; the hydroxyapatite is added into magnesium chloride and magnesium oxide, added with water to be dissolved, to prepare magnesium oxychloride adhesive; a hand lay-up bone pre-fabricated piece is paved with pulp and glass fiber cloth, flattened, paved uniformly and brushed with glue; and then the prefabricated outer skin is paved and compacted, the seam is sealed by plastic thin film, cured and stripped; the product is trimmed within one day after stripping, and a medical composite glass fiber strontium containing enhanced bone cement product is prepared. The composite material prepared by the invention has the advantages of uniform glass fiber dispersion and good combination of the strontium containing hydroxyapatite and a matrix interface, and biomedical composite material with very good application prospect.

The invention relates to an infusion pump assembly, in particular to a multi-level flow control device applied to an infusion pump. Through cooperation among arc-shaped protrusions, an upper groove, amiddle groove and a lower groove, a liquid outlet is matched with a lateral channel A, a lateral channel B and a lateral channel C, and therefore flow adjustment is achieved. The device has the advantages that the structure is simple, control is simple, microscale accurate control and supply of medicine are achieved, multi-level flow control can also be achieved, and clinical use requirements aremet.

The invention belongs to the field of medicines, and in particular relates to a postoperative washing agent and a preparation method thereof; the postoperative washing agent is composed of sodium hyaluronate, a chitin derivative and a cross-linking agent, wherein the mass ratio of the sodium hyaluronate, the chitin derivative to the cross-linking agent is 1:(0.3-1):(0.1-0.5). The preparation method disclosed by the invention comprises the following steps: weighing and mixing the sodium hyaluronate, the chitin derivative and the cross-linking agent according to the formula, grinding into fine powder, sieving fine powder through a 200-mesh sieve, packaging sieved fine powder by using an aluminium foil bag, sterilizing through ethylene oxide or microwave, and obtaining the postoperative washing agent. The postoperative washing agent and the preparation method thereof disclosed by the invention have the advantages that various components of medicines are matched with each other and used by being prepared into the washing agent; the postoperative washing agent has the obvious effects for preventing postoperative joint tissue adhesion, recovering and healing wound surfaces and easing pain; and furthermore, the postoperative washing agent disclosed by the invention is steady in quality, low in cost, convenient for use and good in tissue adhesion and accords with clinical use requirements.

The present invention discloses a metformin and fenofibric acid complex and a preparation thereof, wherein metformin and fenofibric acid are subjected to a direct salt forming reaction to obtain the complex. According to the present invention, the experiment results prove that the complex is the enteric sustained-release preparation prepared from the active components, and can release the two active components such as metformin and fenofibric acid in a simulated artificial intestinal juice, wherein the metformin and the fenofibric acid have good release consistency, such that the complex can be used for preparing pharmaceutical preparations for treatment of hyperlipoidemia, diabetes and other metabolic diseases; with the complex, the problem of the release inconsistency caused by the inconsistent pharmacokinetics between the two active components is solved, the significant sustained-release property is provided, the food effect and the early release condition do not exist, and the clinical use requirements of pharmaceutical preparations can be met; and the advantages of good compressibility, simple preparation process, easy scalization, low cost, stable quality and the like are provided.