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Preparation method of medical composite glass fiber strontium containing enhanced bone cement product

A glass fiber and bone cement technology, applied in chemical instruments and methods, medical science, phosphorus compounds, etc., can solve atrophy, poor mechanical compatibility between metal materials and bone tissue, and affect the activity and proliferation of seed cells or growth factors and other problems, to achieve the effect of reducing the size and meeting the requirements of clinical use

Inactive Publication Date: 2010-08-04
李胜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many biomaterials prepared from metal and polymer materials are used for the treatment of orthopedic diseases, but these materials have significant defects, such as: the mechanical compatibility of metal materials with bone tissue is not good, resulting in loosening or Dislocation; produce stress shielding effect, resulting in fracture loosening or bone atrophy, can not form osteoporosis at the fracture site, prone to secondary fractures; the release of metal ions will cause allergic reactions; metal materials require secondary surgery to remove the implant; current clinical Acidic substances are released when the polymer materials used degrade, causing non-bacterial inflammatory responses and affecting the activity and proliferation of seed cells or growth factors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1) Weigh calcium nitrate Ca(NO 3 ) 2 , diammonium hydrogen phosphate (NH 4 ) 2 HPO 4 and urea CO(NH 2 ) 2 , after mixing, add 2 parts of strontium hydrogen phosphate in the same volume ratio, stir for 10 minutes to form a hydroxyapatite precursor solution, react at a temperature of 260 ° C for 6 hours, filter, put it into a muffle furnace for calcination, and the time is 6 Hours, after natural cooling and grinding, the strontium-containing hydroxyapatite is obtained;

[0039] 2) Dissolve 5 grams of magnesium chloride with 20 grams of water to make a solution with a certain concentration, then add 2 grams of magnesium oxide, mix and stir for 10 minutes, then add 0.6 grams of water-soluble polyester resin, after the water reducing agent, fully stir for 15 minutes, Finally, chopped glass fiber is added to make magnesium oxychloride adhesive;

[0040] 3) Add 3 grams of strontium-containing hydroxyapatite to 30 grams of magnesium oxychloride adhesive, mix ingredients,...

Embodiment 2

[0044] 1) Weigh calcium nitrate Ca(NO 3 ) 2 , diammonium hydrogen phosphate (NH 4 ) 2 HPO 4 and urea CO(NH 2 ) 2 , after mixing, add 3 parts of strontium carbonate in the same volume ratio, stir for 10 minutes to form a hydroxyapatite precursor solution, react at a temperature of 280 ° C for 6.5 hours, filter it, and put it into a muffle furnace for calcination for 7 hours , after natural cooling and grinding, the strontium-containing hydroxyapatite is obtained;

[0045] 2) Dissolve 6 grams of magnesium chloride with 20 grams of water to make a solution with a certain concentration, then add 2 grams of magnesium oxide, mix and stir for 10 minutes, then add 0.5 grams of water-soluble polyester resin and 0.2 grams of mineral powder filler, water reducer Finally, fully stir for 20 minutes, and finally add chopped glass fiber to make magnesium oxychloride adhesive;

[0046] 3) Add 4 grams of strontium-containing hydroxyapatite to 30 grams of magnesium oxychloride adhesive, ...

Embodiment 3

[0050] 1) Weigh calcium nitrate Ca(NO 3 ) 2 , diammonium hydrogen phosphate (NH 4 ) 2 HPO 4 and urea CO(NH2 ) 2 , after mixing, add 3 parts of strontium phosphate in the same volume ratio, stir for 10 minutes to form a hydroxyapatite precursor solution, react at a temperature of 300°C for 6 hours, filter it, and put it into a muffle furnace for calcination for 7 hours , after natural cooling and grinding, the strontium-containing hydroxyapatite is obtained;

[0051] 2) Dissolve 7 grams of magnesium chloride with 20 grams of water to make a solution with a certain concentration, then add 2 grams of magnesium oxide, mix and stir for 10 minutes, then add 0.4 grams of polyacrylamide, after the water reducer, fully stir for 20 minutes, and finally add Chopped glass fiber to make magnesium oxychloride adhesive;

[0052] 3) Add 4 grams of strontium-containing hydroxyapatite to 30 grams of magnesium oxychloride adhesive, mix ingredients, stir well, and set aside;

[0053] 4) Th...

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Abstract

Calcium nitrate, diammonium phosphate and urea are mixed and added with strontium phosphate to be mixed, stirred and heated, to prepare strontium containing hydroxyapatite; the hydroxyapatite is added into magnesium chloride and magnesium oxide, added with water to be dissolved, to prepare magnesium oxychloride adhesive; a hand lay-up bone pre-fabricated piece is paved with pulp and glass fiber cloth, flattened, paved uniformly and brushed with glue; and then the prefabricated outer skin is paved and compacted, the seam is sealed by plastic thin film, cured and stripped; the product is trimmed within one day after stripping, and a medical composite glass fiber strontium containing enhanced bone cement product is prepared. The composite material prepared by the invention has the advantages of uniform glass fiber dispersion and good combination of the strontium containing hydroxyapatite and a matrix interface, and biomedical composite material with very good application prospect.

Description

1. Technical field: [0001] The invention relates to a preparation method of a strontium-containing reinforced bone cement product, in particular to a preparation method of a medical composite carbon fiber strontium-containing reinforced bone cement product. 2. Background technology: [0002] Because of population aging, pathological changes, traffic accidents, earthquakes and other reasons, a large number of fracture patients need fracture internal fixation every year. Many biomaterials prepared from metal and polymer materials are used for the treatment of orthopedic diseases, but these materials have significant defects, such as: the mechanical compatibility of metal materials with bone tissue is not good, resulting in loosening or Dislocation; produce stress shielding effect, resulting in fracture loosening or bone atrophy, can not form osteoporosis at the fracture site, prone to secondary fractures; the release of metal ions will cause allergic reactions; metal materials...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/50C04B22/06C01B25/32A61F2/28
Inventor 李胜李斌李文宋明晨郑丽文葛玲陈坤宇
Owner 李胜
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