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Vascular Imaging Enhancer

A vascular imaging and enhancing agent technology, applied in echo/ultrasonic imaging agents and other directions, can solve the problems of long time delay for penetration promotion and low imaging quality, and achieve the advantages of short time delay for penetration promotion, simple mixing process, and improved contrast. Effect

Active Publication Date: 2019-01-15
SHANGHAI YUKING WATER SOLUBLE MATERIAL TECH
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0007] The invention provides a vascular imaging enhancer, which overcomes the problems of low imaging quality and long time-lag in promoting penetration of existing infrared vascular imaging instruments, can quickly improve the transparency of skin tissue in a short time, and improve the infrared penetration of the skin. Medium penetration and penetration depth, thereby improving the imaging quality and accuracy of blood vessels, and at the same time, it is less irritating to the skin

Method used

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Examples

Experimental program
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Effect test

Embodiment 1-6

[0035] According to formulas 1-6 and specific preparation methods, the blood vessel imaging enhancers of Examples 1-6 of the present application were prepared. Rats weighing 190-200 g were anesthetized by intraperitoneal injection of anesthesia (2% chloral hydrate mixed with 10% ulax, 1ml / 100g body weight), the hair on the back was cut off, and the rest of the hair was carefully removed with depilatory cream. Select the action area with a diameter of about 1 cm on the back of the rat, apply the vascular imaging enhancer of the present invention evenly, and act for 1 to 2 minutes, then use a visible-near-infrared optical fiber spectrometer to detect the reflectivity of the infrared reflected light of the back skin of the rat, and compare it with the untreated one. The rat skin (blank group) coated with vascular imaging enhancer is compared to investigate the effect of vascular imaging enhancer, and the results of the comparison test are shown in Table 2:

[0036] Table 2 Infrar...

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Abstract

The invention provides an angiography enhancer. The angiography enhancer comprises 2.5-5.0% of alkaloids, 1.5-4.5% of a chemical penetrating agent, 70-85% of polyol and 10-20% of other components. The alkaloids comprise two or more of berberine hydrochloride, piperine, sinomenine, radix aconite total alkaloids and mesaconitine, the chemical penetrating agent is one or more of thiazone, isopropyl myristate, propylene glycol and menthol, and the polyol is one or more of sorbitol, glycerin and polyethylene glycol-400. The angiography enhancer compounding natural alkaloid penetration promoters with chemical penetration promoters increases the amount of infrared lights penetrating through skins, reduces the penetration promotion time lag, makes skin tissues be transparent in 1-2min, greatly improves the contrast between blood vessels and surrounding tissues thereof under the infrared lights, substantially improves the quality and the precision of development, contains no skin sensitizing or high-irritation components, is prepared through a simple technology according to a simple ratio, and is suitable for large-scale industrial production.

Description

technical field [0001] The invention belongs to the technical field of blood vessel imaging enhancers, and in particular relates to a blood vessel imaging enhancer. Background technique [0002] In recent years, with the development of optical diagnostic technology and the need for non-invasive medical treatment, the application of photonic technologies such as optical imaging and laser therapy has developed into one of the important hotspots in biological and medical research. However, the turbidity of biological tissue limits the penetration depth of light in tissue, so that many optical diagnostic techniques can only be used for the detection of superficial tissue. [0003] Intravenous infusion is a treatment method that injects a large amount of sterile solution or medicine into the human body through a subcutaneous vein. Using intravenous infusion of medicine or plasma is the fastest way to save the life of the injured. Successful venipuncture with a needle is the firs...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/22
CPCA61K49/22
Inventor 王宇朱广东陈占熊俊超
Owner SHANGHAI YUKING WATER SOLUBLE MATERIAL TECH
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