120results about How to "Reduce drug risk" patented technology

The present invention relates to an SNP (single nucleotide polymorphism) combination, detection method and kit for detecting liver damage susceptible genotype of an antitubercular drug and belongs to the technical field of medical molecular biological diagnosis; the SNP combination includes 7 SNP sites, and nucleotide sequences of the 7 SNP sites are shown sequentially as in SEQ ID NO. 1-7; the present invention also relates to an SNP detection method, comprising PCR (polymerase chain reaction) amplification and double-labeled probe melting curve analytical reaction, and primer pairs and double-labeled probe sequences for detection of the 7 SNP sites are shown as in SEQ ID NO. 8-20. The SNP site combination, detection method and kit provided herein enables quick, accurate, simple and high-throughput detection for a patient's genotype and prediction for the liver damage risk due to the patient using the antitubercular drug.

The invention discloses a medicinal composition for treating or preventing the obesity and metabolic syndromes, and belongs to the medicine field. The medicinal composition treats orlistat and acarbose as medicinal active components, so the application amount of orlistat in the medicinal composition is substantially reduced, thereby the risk of the damage of orlistat to the liver of a body is reduced. The medicinal composition has a substantial synergistic effect when the medicinal composition is used for treating or preventing the obesity and the metabolic syndromes, can reduces the diabetes and angiocardiopathy suffering risks of obese patients, and has a wide medical application prospect.

The invention discloses a sodium fusidate freeze-dried powder injection, including the following components and contents (weight portions) of 450 to 550 of sodium fusidate, 30 to 500 of glycin and 40 to 600 of arginine. The sodium fusidate freeze-dried powder injection has good long-period stability and improves the medication safety for the patient and reduces the medication risk, because certain quantity of stabilizer is added into the sodium fusidate freeze-dried powder injection.

The invention belongs to the technical field of pharmaceutical preparations and specifically relates to a temozolomide lyophilized powder preparation. The temozolomide lyophilized powder preparation comprises an active ingredient of temozolomide or a pharmaceutically acceptable salt thereof, and a solution before lyophilization further contains an excipient, a wetting agent, a buffer agent, an osmotic pressure regulating agent, a pH regulating agent, water for injection and an organic solvent, wherein the organic solvent is selected from one or any combination of ethanol, acetone, isopropanol, n-propanol, butanone, sec-butyl alcohol and methanol, and is preferably ethanol. The temozolomide lyophilized powder preparation provided by the invention has the advantages of stable quality, high re-dissolution speed and a small residual amount of the organic solvent. The invention further provides a method for preparing the preparation. The process provided by the invention is simple and convenient in preparation process and easy to control production links, the organic solvent accounts for a relatively small part of total volume of material liquid, the pollution to production equipment and environment caused by the organic solvent is reduced, and thus the method is suitable for large-scale production.

The invention discloses a planting method for improving the quality of corn, and relates to the technical field of corn planting. The planting method comprises the following steps of land selection and preparation, seed selection, seed treatment, sowing, film mulching, field management and harvesting. By means of the planting method, the survive rate of the corn can be improved, plant diseases and insect pests can be reduced, and the overall quality is improved.

The invention relates to an argatroban injection and a preparation method thereof. The injection is composed of 1 part of argatroban, 80-150 parts of a solubilizer, a proper amount of a pH regulation agent, and injection water. The addition amount of the pH regulation agent satisfies that the pH value of a full amount of the solution is regulated to 4.2-7.0. During medicine solution preparation, the medicine solution with argatroban added is not subjected to an active carbon absorption treatment. The argatroban injection provided by the invention has the advantages of no organic solvent, simple components, stable quality, and convenient application.

The invention provides curcumin nano micelle eye drops. The curcumin nano micelle eye drops comprise curcuminoid, a chitosan nano micelle drug carrier, a surfactant, a co-surfactant and medical pure water, wherein the mass volume percentage of curcuminoid is 0.005-0.02% and the mass volume percentage of the chitosan nano micelle drug carrier is 0.01-0.1%. The curcumin nano micelle eye drops provided by the invention are good in stability, high in bioavailability and low dosage.

The invention discloses a wheat planting method. The wheat planting method includes the steps of soil selecting and leveling, seed treatment, sowing, pesticide applying management and harvesting. According to the wheat planting method, wheat seeds are treated, so that the germination rate of the wheat seeds and the survival rate of seedlings obtained after sowing is completed are greatly increased, the germination rate of the wheat seeds reaches up to 99.2%, and the germination time of the wheat seeds is shortened by 40% compared with common wheat germination time; pesticide is scientifically applied, so that wheat diseases and pests are effectively prevented and treated, wheat pesticide damage is reduced, pesticide use risks are reduced, the influences on the environment are reduced, and harm to working staff is reduced; in addition, by means of the method, the pesticide use cost and the labor cost are reduced; by means of the planting method, wheat is good in growth vigor and good mature appearance, the disease resistance of the wheat is greatly enhanced, seeds are full, live stems are mature, and the physiological activity of the wheat is high.

The invention relates to a traditional Chinese medicine processing device, in particular to a processing device of toxic traditional Chinese medicines. The technical problem to be solved by the invention is to provide device for carrying out hydrolysis treatment on highly toxic traditional Chinese medicines, and effectively reducing toxic components in the toxic traditional Chinese medicines. Theprocessing device comprises a mounting bottom plate, a toxic water discharge pipe, a supporting rod, a fixing frame, a driving mechanism, a first drainage pipe, a first baffle, a second drainage pipe,a soaking frame, a first inclined mesh plate, a first mounting plate, a second inclined mesh plate, a cleaning frame, a second mounting plate, a first lifting rod, a material selecting frame, a mounting wall plate, a water conveying pipe, a water storage tank, a discharging pipe, a first cover plate, a fixing mechanism, a first net plate, a water conveying mechanism, a second cover plate and a first fixing plate. The processing device disclosed by the invention has the beneficial effects that the toxic traditional Chinese medicines can be subjected to hydrolytic treatment, and toxic components in the toxic traditional Chinese medicines are effectively reduced.

A medication risk mitigation method utilizing three interventions: a prospective intervention performed by a prescriber, a concurrent intervention performed by a pharmacist and a retroactive intervention performed by a pharmacist. At each intervention, the system of the instant invention utilizes a computer program to compare each prescribed medication to a series of intrinsic and extrinsic data sources in order to identify potential contraindications and, if necessary, modify a prescription. The system also permits secure messaging between prescribers and pharmacists, each with access to the computer program, so as to facilitate communication and reduce medication risks. The system of this invention also permits modeling for hypothetical medication modifications based on the same intrinsic and extrinsic data sources.

The invention discloses an oral pharmaceutical composition for treating or preventing obesity-related hypertension and its application and belongs to the field of medicine. The pharmaceutical composition comprises orlistat and lol-suffixed pharmaceutical active ingredients. The usage of orlistat and lol-suffixed pharmaceuticals in the pharmaceutical composition is greatly reduced, thus the risk of pharmaceuticals injuring the human body is reduced. The oral pharmaceutical composition has significant synergistic effect in treating or preventing obesity-related hypertension, can reduce the weight of a patient and the risk of hypertension being complicated by cardiovascular diseases and has higher social value.

The invention relates to the technical field of antitumor drugs, and discloses a composition containing paclitaxel and a preparation method thereof. The composition containing paclitaxel comprises 1 part by weight of paclitaxel and 1.2-15 parts by weight of egg yolk lecithin; the pH value range of the composition is 4.0-6.0. According to the composition containing paclitaxel of the invention, egg yolk lecithin is adopted as an emulsifier; the pH value of the composition is adjusted to be within a proper range; no polyoxyethylated castor oil with large toxicity is adopted; no ethanol is contained; the medication risk of the composition containing paclitaxel is reduced; and the patient compliance is improved.

The invention discloses a medical composition for treating metabolic syndromes, belonging to the field of medicines, and in particular relates to a medical composition containing orlistat or cetilistat and actos, wherein the composition is solid preparations such as compressed tablets, dispersible tablets, sustained release tablets, capsules, granules, and the like. In experiments, the medical composition containing the orlistat or the cetilistat and the actos is accidentally found to have obvious synergistic effect on the aspects of reducing the blood pressure, the serum total cholesterol, the serum triglyceride and the low density lipoprotein cholesterin and enhancing the carbohydrate tolerance.

The invention provides a method for applying a pesticide on corn plants. The method comprises steps of selecting a corn lodging-resistant agent, a bactericide and an insecticide which have the consistent medicinal pH values; respectively weighing 7.5-12 grams of the corn lodging-resistant agent, 8-18 grams of the bactericide and 7.5-13.5 grams of the insecticide according to the dosages of the corn lodging-resistant agent, the bactericide and the insecticide, then adding water for 25-30 kilograms, and mixing so as to obtain a spray dosage of compound liquid medicine for each mu of corns, wherein the corn lodging-resistant agent consists of one of or a mixture of Jindele and Zhuangfengan, the bactericide consists of one of or a mixture of triadimefon and tebuconazole, and the insecticide is carbosulfan; when the leaves of the corns grow into 8-12 blades, adopting the compound liquid medicine to spray onto the corns. The method for applying the pesticide on corn plants has the advantages of labor saving, time saving, small hazard, good control effect and reduced cost.

The invention provides feed for milking sows and belongs to the field of pig feed. The feed for the milking sows solves the problems that the sows have low immunity, and drug residue is caused because chemical medicine is injected into the sows. The feed for the milking sows comprises, by weight, 550-600 parts of corn flour, 50-100 parts of wheat bran, 20-50 parts of fish meal, 20-50 parts of silkworm chrysalis, 50-100 parts of fermented oil tea cakes, 5-10 parts of mango leaf extracts, 30-80 parts of whey powder, 13-16 parts of calcium hydrophosphate, 10-50 parts of limestone powder, 0.05-0.1 part of papain, 0.1-0.3 part of lysine, 0.1-0.3 part of methionine, 0.12-0.16 part of iron, 0.001-0.005 part of manganese, 0.05-0.15 part of zinc, 0.003-0.008 part of copper and 0.5-1.5 parts of decavitamin. According to the feed for the milking sows, nutrient substances in the feed are reasonably matched due to variety selection and content selection of materials, galactopoiesis of the milking sows is facilitated, the immunity of the milking sows is improved, and the drug use risk of the sows is reduced.

The invention provides an impurity in ziprasidone hydrochloride. The impurity has a structure as shown in formula 1. The impurity with a specific structure is obtained on the basis that chlorine impurities are doped in the ziprasidone hydrochloride preparation process, or impurities are brought in and transferred into a final product in the dechlorination step in the acylation reaction process, and the corresponding impurity preparation steps are provided, so that corresponding technical support is provided for preparation of ziprasidone hydrochloride. The synthesis method provided by the invention is simple in process, strong in controllability and mild in condition, can be used for quality standard establishment and quality control links in ziprasidone hydrochloride process research and development, production and the like, and provides technical support for the medication safety of ziprasidone hydrochloride. The method can be used for quality research such as qualitative and quantitative analysis of impurities in ziprasidone hydrochloride synthesis, so that improvement of the quality of ziprasidone hydrochloride is facilitated, and important guiding significance is provided for reducing the medication risk of ziprasidone hydrochloride.

The invention discloses a compound vitamin injection medicine composition and a preparation method, and belongs to the field of medicine manufacturing. According to the compound vitamin injection medicine composition, the active ingredients per dosage unit comprise 110 mg of vitamin B, 5 mg of riboflavin in riboflavin sodium phosphate and 200 mg of vitamin C. The compound vitamin injection medicine composition and the preparation method have the advantages that the PH is stable, the PH value is small in change, the content of main drugs is stable, related matter is less, the process is simplified, the liquid dosing time is shortened, and the operation difficulty is lowered.

The invention provides a material for a transfusion hose and an application of the material. The material is obtained by coextruding at least one outer layer material, a middle layer material and an inner layer material, wherein the outer layer material is prepared from the following components in percentage by weight: 50-99 percent of PP and 1-50 percent of SEBS, totally 100 percent; the middle layer material is prepared from the following components in percentage by weight: 30-70 percent of PP and 30-70 percent of SEBS, totally 100 percent; the inner layer material is prepared from the following components in percentage by weight: 10-45 percent of PP and 55-90 percent of SEBS, totally 100 percent. The material is high in weldability, soft, high in transparency, high in elasticity and suitable for coextrusion.