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Oral preparation of monosialotetrahexosyl ganglioside sodium

A technology of ganglioside sodium and monosialic acid, which is applied in the field of medicine, can solve the problem of high cost, achieve low cost, improve bioavailability, and reduce the pain of medication

Inactive Publication Date: 2015-04-08
哈尔滨医科大学科技开发总公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The present invention aims to solve the technical problem of monosialotetrahexosyl ganglioside sodium injection on the human body and high cost; and provides an oral preparation of monosialotetrahexosyl ganglioside sodium

Method used

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  • Oral preparation of monosialotetrahexosyl ganglioside sodium
  • Oral preparation of monosialotetrahexosyl ganglioside sodium
  • Oral preparation of monosialotetrahexosyl ganglioside sodium

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0029] Specific embodiment one: the preparation method of monosialotetrahexosylganglioside sodium tablet in the present embodiment is as follows: 500g monosialotetrahexosyl ganglioside sodium and 1000g pregelatinized starch, spray-dried manna 350g of alcohol, 100g of microcrystalline cellulose, and 40g of sodium carboxymethyl starch were put into a three-dimensional motion mixer and mixed for 10-30 minutes, then added 10g of magnesium stearate and continued to mix for 5-20 minutes, and the resulting material was pressed into a form such as Tablets with the following technical specifications:

[0030] Rated mass 200mg

[0031] 5mm in diameter

[0032] Thickness 3mm

[0033] The tablets may then be uniformly coated by continuous spraying in a suitable coater with conventional polymer-containing coatings or conventional dragee coatings.

specific Embodiment approach 2

[0034] Specific embodiment two: In this embodiment, 250g monosialotetrahexosyl ganglioside sodium and 2000g mannitol, 1000g pregelatinized starch, and 450g microcrystalline cellulose are dropped into a three-dimensional motion mixer and mixed for 5-10 minutes, Add an appropriate amount of 10% PVP aqueous solution, continue mixing for 5-10 minutes to granulate, dry the obtained material at 70°C for 3 hours, granulate, add 50g of micropowder silica gel, 100g of sodium carboxymethyl starch for total mixing, and select 2 #Empty capsules are filled with capsules, so that the loading capacity of each capsule is 0.4g, and polished.

[0035] Adopt following experiment verification invention effect

[0036] 1. Experimental animals and preparation

[0037] Take 50 female SD (Sprague-Dawley) rats, requirements: healthy and sterile, body weight 210-250g. The breeding room maintains a temperature of 18-26°C and a relative humidity of 40-70%, avoiding direct sunlight and excessive noise, ...

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Abstract

The invention discloses an oral preparation of monosialotetrahexosyl ganglioside sodium, belongs to the field of medicines, and aims at solving the problems that a monosialotetrahexosyl ganglioside sodium injection hurts a human body and is high in cost. A monosialotetrahexosyl ganglioside sodium tablet is prepared from monosialotetrahexosyl ganglioside sodium, a filler, a drying adhesive, a disintegrating agent and a lubricant; and a hard capsule of monosialotetrahexosyl ganglioside sodium is prepared from monosialotetrahexosyl ganglioside sodium, a diluent, a lubricant, a glidant, a disintegrating agent and a wetting agent. The oral preparation has the advantages of relatively low cost, small medication pain and high medicine effect.

Description

technical field [0001] The invention belongs to the field of medicines; in particular, it relates to an oral preparation mainly composed of monosialotetrahexosyl ganglioside sodium, including tablets and hard capsules. Background technique [0002] The structural formula of monosialotetrahexosyl ganglioside sodium: [0003] [0004] The molecular formula of monosialotetrahexosyl ganglioside sodium is C 73 h 130 N 3 NaO 31 or C 75 h 134 N 3 NaO 31 The molecular weight is 1568.84 or 1597.18. [0005] Monosialotetrahexosyl ganglioside sodium is a substance that is extracted from pig brain and has an effect on nerve cell function damage. It can promote the functional recovery of central nervous system damage caused by various reasons. The mechanism of action is to promote "Neural remodeling neuroplasticity" (including survival of nerve cells, axon growth and synaptogenesis) monosialotetrahexosyl ganglioside is protective against secondary neurodegeneration after inju...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/48A61K31/7032A61P25/28A61P9/00A61P25/02A61P25/16
Inventor 王永强尤旭王蕾刘培伟周萍付微微胡松梅杨明
Owner 哈尔滨医科大学科技开发总公司
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